Nonspecific Urethritis

Kaufman, Richard E.; Wiesner, Paul J.

doi:10.1056/nejm197411282912208

Cited by 27 publications

(4 citation statements)

References 2 publications

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“…In recent years, there has been a growing indication that Chlamydia trachomatis may be at least one candidate. Non-gonococcal urethritis is reportedly accompanied by prostatitis in 30-100% of cases (Kaufman & Wiesner, 1974;Oates, 1976 (1991) found that Chlamydia trachomatis could be cultured from the urethral swabs of 28% of men with non-bacterial prostatitis after prostatic massage. This confirmed an earlier report, using tissue culture and immunofluorescence, of the presence of the organism in the prostatic fluid from six men with chronic prostatitis (Bruce & Reid, 1989).…”

Section: Non-bacterial Prostatitismentioning

confidence: 99%

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Purvis¹,

Christiansen²

1993

Int J of Andrology

177

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The following are the conclusions that can be derived from a review of the literature regarding the role of infection in the aetiology of male infertility. (i) Temporary inflammatory episodes in the male reproductive tract which are self-limiting are probably common. (ii) Caution should be exercised in the use of leukospermia or bacteriospermia as parameters for glandular infection. (iii) There is a need for alternative techniques for detecting non-symptomatic deep pelvic infections in the male; one technique of great promise is rectal ultrasound. (iv) Rectal ultrasound indicates that a large number of men with poor sperm quality have a non-symptomatic, chronic prostatovesiculitis. (v) Increasing evidence implicates Chlamydia trachomatis as being a major cause of chronic non-bacterial prostatitis. (vi) An important aspect of chlamydial infections in men may be that the male accessory sex glands may function as reservoirs for the organism, increasing the probability of infection in the female. (vii) Ureaplasma urealyticum may also play an important aetiological role in male infertility but its significance is confounded by its acknowledged function as a commensal in the reproductive tract. (viii) One of the manifestations of male reproductive tract infection is the induction of sperm autoantibodies. (ix) There is a need for more systematic controlled studies of the effects of antibiotic treatment on sperm quality with different preparations for extended periods using patient groups in which a glandular infection has been verified, e.g. by rectal ultrasonography.

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Section: Non-bacterial Prostatitismentioning

confidence: 99%

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Purvis¹,

Christiansen²

1993

Int J of Andrology

177

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“…1 Chlamydia disproportionately affects adolescents and young adults, with those aged 15 to 24 years experiencing higher rates than any other age group. 1 Potential sequelae of untreated infections include epididymitis in men 2,3 and pelvic inflammatory disease, infertility, ectopic pregnancy, and chronic pelvic pain in women. [4][5][6][7][8][9] It is estimated that 90% of Chlamydiainfected males [10][11][12][13] and females [10][11][12] are asymptomatic; therefore, most infections will be detected only through routine screening.…”

mentioning

confidence: 99%

Correlates of Readiness to Receive Chlamydia Screening Among 2 Populations of Youths

Blake

Lemay²,

Indurkhya³

2007

Arch Pediatr Adolesc Med

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“…It also leads to significant morbidity, giving a relative risk of ectopic pregnancy of 2.4-7.9 6 and causing epididymitis in approximately 3% of infected males. 7 These characteristics, and the fact that this disease is readily treatable make it an excellent candidate for a screening program. There are a variety of available methods with which to screen for Ct including culture, the Gen-Probe PACE2 assay (a nucleic acid probe assay), and more recently, LCx.…”

mentioning

confidence: 99%

Comparison of Abbott LCxChlamydia trachomatis assay with gen-probe PACE2 and culture

Young

Craft

Day

et al. 2000

Infect. Dis. Obstet. Gynecol.

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In this study the LCx assay (a nucleic acid amplification assay) for Chlamydia trachomatis in endocervical samples was compared with the Gen‐Probe PACE2 assay (a nucleic acid probe assay) for endocervical samples, and with endocervical culture. In addition, the efficacy of the LCx assay was determined for midstream clean‐catch urine samples because it is often necessary to obtain such a sample for routine urine culture and it is simpler to collect only a single sample without also collecting a first‐void urine for LCx. Endocervical specimens from 205 patients were tested for C. trachomatis via LCx and PACE2. Of these patients, 203 were tested by culture. Midstream clean‐catch urine samples from 75 of these patients were tested by LCx. The sensitivities and specificities for these assays, after discrepant analysis, were 100 and 98.9% for LCx of endocervical samples, 52.4 and 100% for PACE2; and 71.4 and 100% for culture. The sensitivity/specificity of LCx for midstream clean‐catch urines was 66.7/98.5%. The apparent prevalence of C. trachomatis in our population was 10.2%. These data indicate that among the methods tested, LCx of endocervical samples had the highest sensitivity for C. trachomatis in this population. The senstivity of the urine LCx assay using midstream clean‐catch collected urines was considerably less than that reported in other studies that used first‐void urines but was higher than that of PACE2. Infect. Dis. Obstet. Gynecol. 8:112–115, 2000. © 2000 Wiley‐Liss, Inc.

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Nonspecific Urethritis

Cited by 27 publications

References 2 publications

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Correlates of Readiness to Receive Chlamydia Screening Among 2 Populations of Youths

Comparison of Abbott LCxChlamydia trachomatis assay with gen-probe PACE2 and culture

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