Nonsteroid Antiinflammatory Agents

Winter, Charles A.

doi:10.1007/978-3-0348-7059-7_5

Cited by 8 publications

(2 citation statements)

References 242 publications

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“…Histamine is thought to be an important mediator in the inflammatory process (Schayer, 1962;Spector & Willoughby, 1964). Most of the NSAID are able to reduce oedema induced experimentally by histamine or histamine-releasers although to a lesser degree than true antihistaminic drugs (Winter, 1966). This is in accordance with our results which indicate that NSAID have only moderate antihistaminic properties.…”

Section: Discussionsupporting

confidence: 92%

The Effects of Non‐steroidal Anti‐inflammatory Drugs on Cholinergic and Histamine‐induced Contractions of Guinea‐pig Isolated Ileum

Famaey¹,

Fontaine²,

Reuse³

1977

British J Pharmacology

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I Eleven non-steroidal anti-inflammatory drugs (NSAID) reversibly inhibited contractions of the longitudinal muscle of the guinea-pig isolated ileum induced by acetylcholine, histamine, electrical transmural stimulation and nicotine in this order of increasing potency.2 After the addition of prostaglandins E,, E2 or F2a, with partially effective concentrations of NSAID (but not with higher concentrations which almost totally prevented the responses) the inhibitory effects of NSAID were reversibly lost, except for electrically induced contractions and prostaglandin F2a* 3 The effects of NSAID may be due to actions on biological membranes or on distribution of ions in addition to their inhibitory effect on prostaglandin synthesis. Prostaglandins may reverse the inhibition by non-selective sensitization of smooth muscle to various agonists.

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Section: Discussionsupporting

confidence: 92%

The Effects of Non‐steroidal Anti‐inflammatory Drugs on Cholinergic and Histamine‐induced Contractions of Guinea‐pig Isolated Ileum

Famaey¹,

Fontaine²,

Reuse³

1977

British J Pharmacology

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“…This model of acute inflammation in rats is simple, yet it has several advantages (Weiner & Piliero, 1970). The oedema produced by mercury developed relatively rapidly, and in a single phase, differing from that produced by kaolin (Vinegar, 1968) or carrageenan (Vinegar, Schreiber & Hugo, 1969) which develop in two phases.…”

Section: Discussionmentioning

confidence: 99%

Effect of Drugs on Rat Paw Oedema Induced by Mercury

Jindal

Kelkar

Vaishnav

1974

British J Pharmacology

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Metallic mercury (0.04 ml) injected into the foot pad of rats induced a consistent inflammatory reaction, which at 4 h showed oedema but no cellular infiltration or vascular changes. The lesions exhibited lymphocytic infiltration, vasodilatation and haemorrhages at 24 and 48 h, and often became cystic after 2–3 weeks, before healing. The oedema volume at 4 h was used to test anti‐inflammatory activity of drugs. Cortisone, phenylbutazone, indomethacin, acetylsalicylic acid, flufenamic acid and propranolol exhibited potent, dose‐related anti‐inflammatory activity. Aminopyrine, chloroquine and chlorpromazine were only moderately effective. Dimercaprol, adrenaline, and to some extent, mepyramine also inhibited mercury‐induced oedema. This simple model of acute inñammation may be useful for preliminary tests of anti‐inflammatory activity.

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Synopsis der Rheumatherapie

Moll¹

1968

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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Nonsteroid Antiinflammatory Agents

Cited by 8 publications

References 242 publications

The Effects of Non‐steroidal Anti‐inflammatory Drugs on Cholinergic and Histamine‐induced Contractions of Guinea‐pig Isolated Ileum

The Effects of Non‐steroidal Anti‐inflammatory Drugs on Cholinergic and Histamine‐induced Contractions of Guinea‐pig Isolated Ileum

Effect of Drugs on Rat Paw Oedema Induced by Mercury

Synopsis der Rheumatherapie

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