Nonsteroid antiinflammatory drugs and tamoxifen for desmoid tumors and carcinoma of the stomach

Waddell, William R.; Cerner, Robert E.; Reich, Marshall P.

doi:10.1002/jso.2930220314

Cited by 146 publications

(63 citation statements)

References 45 publications

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“…Anecdotal reports suggest that non-steroidal antiin¯ammatory drugs cause remission of aggressive ®bromatoses in patients (Lackner et al, 1997;Kirsch, 1991;Beliveau and Graham, 1984;Waddell et al, 1983). Although previous studies suggest a role for prostaglandins and cyclooxygenase in colonic neoplasia (Williams et al, 1997(Williams et al, , 1999Oshima et al, 1996;He et al, 1999), there are enough di erences between aggressive ®bromatosis and colonic neoplasia that data from one of these tumors can not be easily generalized to the other.…”

Section: Introductionmentioning

confidence: 99%

Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor)

Poon

Smits

et al. 2001

Oncogene

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Aggressive ®bromatosis is a locally invasive soft tissue lesion. Seventy-®ve per cent of cases harbor a somatic mutation in either the APC or b-catenin genes, resulting in b-catenin protein stabilization. Cyclooxygenase-2 (COX-2) is an enzyme involved in prostaglandin synthesis that modulates the formation of colonic neoplasia, especially in cases due to mutations resulting in b-catenin stabilization. Human aggressive ®broma-toses and lesions from the Apc+/Apc1638N mouse (a murine model for Apc-driven ®bromatosis) demonstrated elevated COX-2 levels. COX-2 blockade either by the selective agent DFU or by non-selective COX blocking agents results in reduced proliferation in human tumor cell cultures. Breeding mice with Cox-27/7 mice resulted in no di erence in number of aggressive ®bromatoses formed, but in a smaller tumor size, while there was a decrease in number of GI lesions by 50%. Mice fed various COX blocking agents also showed a decline in tumor size. COX-2 expression was regulated by tcf-dependent transcription in this lesion. COX-2 partially regulates proliferation due to b-catenin stabilization in aggressive ®bromatosis. Although COX blockade alone does not cause tumor regression, this data suggests that it may have a role as an adjuvant therapy to slow tumor growth in this lesion. Oncogene (2001) 20, 451 ± 460.

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Section: Introductionmentioning

confidence: 99%

Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor)

Poon

Smits

et al. 2001

Oncogene

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“…Therefore, alternative treatment strategies, including radiation therapy [9][10][11], nonsteroidal antiinflammatory agents [12], antiestrogen compounds [13][14][15][16][17], and cytotoxic chemotherapy [18,19] have been employed.…”

Section: Discussionmentioning

confidence: 99%

A Case of Turner's Syndrome Complicated with Desmoid Tumor of the Transverse Colon.

et al. 1999

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Summary: The association of Turner's syndrome and endometrial carcinoma has been previously established, but has never been described in conjunction with a desmoid tumor of the colon. A case is described of a colonic desmoid tumor developing in a 38-year-old female with Turner's syndrome. The association has not been previously reported. In this report, we describe a 38-yearold woman who has Turner's syndrome with a colonic desmoid and review the literature.

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“…Other treatment modalities such as radiation, antihormonal therapy, interferon, cytotoxic drugs, and isolated limb perfusion (ILP) have been tried alone or in combination with surgery but without conclusive effects (Waddell et al 1983, Rock et al 1984, Wilcken and Tattersall 1991, Fernberg et al 1999, Lev-Chelouche et al 1999, Leithner et al 2000, Raguse et al 2004. Spontaneous disappearance of desmoid tumors has occasionally been reported (Dahn et al 1963, Enzinger and Shiraki 1967, Rock et al 1984.…”

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confidence: 99%

Clinical and imaging observations of desmoid tumors left without treatment

et al. 2006

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Background Until now, surgical treatment has been the mainstay in the treatment of desmoid tumors, even though it is associated with a high recurrence rate. There have, however, been occasional case reports showing that desmoid tumors may spontaneously decrease in size or even disappear.Patients and methods This is a retrospective review of 8 patients with abdominal (5) or extra-abdominal (3) desmoid tumors who were followed both clinically and with imaging techniques (sonography, CT or MRI). Mean follow-up time was 4.4 (0.8-7.5) years. Tumor volume was assessed in each investigation and followed over time.Results 3 tumors disappeared, 2 diminished in size, 1 did not change and 2 tumors became larger, 1 of which had trippled in volume at the latest follow-up.Interpretation Desmoid tumors have probably been overtreated in the past. Many of them tend to regress spontaneously.

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Nonsteroid antiinflammatory drugs and tamoxifen for desmoid tumors and carcinoma of the stomach

Cited by 146 publications

References 45 publications

Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor)

Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor)

A Case of Turner's Syndrome Complicated with Desmoid Tumor of the Transverse Colon.

Clinical and imaging observations of desmoid tumors left without treatment

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