Nonsteroidal Anti-Inflammatory Drug Enteropathy

Morris, Allan J.

doi:10.1016/s1052-5157(18)30224-1

Cited by 20 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NSAID enteropathy [10,33,34] has been recognized in recent decades as an important cause of small bowel ulcers. Some previously assumed nonspecific small bowel ulcers may have been attributable to chronic NSAID use, especially those with diaphragm changes in the small intestine.…”

Section: Discussionmentioning

confidence: 99%

Long-term follow-up of nonspecific small bowel ulcers with a benign course and no requirement for surgery: is this a distinct group?

Wang

Yang

et al. 2011

BMC Gastroenterol

View full text Add to dashboard Cite

BackgroundNonspecific small bowel ulcers are rare and surgical intervention is often believed to be elective. Since the extensive investigation of the small bowel in the 1990s, there have been limited reports of these ulcers and the updates have been unsatisfactory. The aim of this study was to explore the clinical features and natural histories of nonspecific small bowel ulcers through prospective observational study.MethodsWe reviewed the medical records of all patients who had undergone ileocolonoscopy or enteroscopy between 2000 and 2005 in a tertiary referral hospital. Seven patients with small bowel ulcers of unknown cause were identified. These patients were prospectively followed in a prolonged observation until March 2010.ResultsAll seven patients (mean age: 54.7 years) presented with mild gastrointestinal symptoms, including chronic diarrhea and/or abdominal pain/discomfort, except for one who was asymptomatic when surveyed for colon polyps. Most patients were suspected of having functional bowel disorders for a long time (4.4 years) before small bowel ulcers were demonstrated on ileoscopy. The ulcers were characteristically multiple, superficial, and small (3-6 mm), locating at the terminal ileum and/or ileocecal valve. Various empirical treatments were applied, and most patients felt partly improved, even relieved. However the gastrointestinal symptoms did not always correlate with the presence of ulcers, and the ulcers tended to be either persistent (4 patients) or recurrent (1 patient). Ileocolonoscopy was repeated 4.1 times during follow-up, even after the lesions had healed. The characteristics of the ulcers, if still present during follow-up, were similar to their earlier characteristics. No patient experienced exacerbation or complications, such as intestinal obstruction, perforation, or bleeding. All patient survived and no surgical intervention was involved during the prolonged follow-up (7.0 years).ConclusionThe reported patients with nonspecific small bowel ulcers experienced benign courses, inconsistent with previous reports. Without extensive investigation, this disease can be confused with functional bowel disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-term follow-up of nonspecific small bowel ulcers with a benign course and no requirement for surgery: is this a distinct group?

Wang

Yang

et al. 2011

BMC Gastroenterol

View full text Add to dashboard Cite

show abstract

“…It may cause weight loss, abdominal pain, or diarrhea. Major complication is iron deficiency anemia, whereas massive small bowel bleeding, perforation, or obstruction are rare [45]. NSAID-related enteropathy was detected by VCE as the cause of bleeding due to small bowel ulcers, of abdominal pain, and of stenosis [46].…”

Section: Abdominal Pain In Nonsteroidal Anti-inflammatory Drug (Nsaidmentioning

confidence: 99%

Video capsule endoscopy in the work-up of abdominal pain

Keuchel¹,

Hagenmüller²

2004

Gastrointestinal Endoscopy Clinics of North America

View full text Add to dashboard Cite

“…57 58 One study has shown that the costs of investigating and managing patients who bleed from the small intestine are different and substantially more expensive than the costs of patients who bleed from other gastrointestinal sites. 59 Outcomes studies of the value of push enteroscopy in non-bleeding conditions suggest that it can be of value in malabsorption, 14 60 Crohn's disease, 61 non-steroidal anti-inflammatory drug toxicity, 62 and worm infestation. 63 It can be usefully performed in non-specialist district general hospitals.…”

Section: Complicationsmentioning

confidence: 99%