Nonsteroidal anti-inflammatory drug use is associated with cancer risk reduction in chronic dialysis patients

Ou, Shuo Ming; Chen, Yung Tai; Chao, Pei Wen; Lee, Yi Jung; Liu, Chia Jen; Yeh, Chiu Mei; Chen, Tzeng Ji; Chen, Tzen Wen; Wu, Yang Chang; Li, Szu Yuan

doi:10.1038/ki.2013.79

Cited by 22 publications

(23 citation statements)

References 41 publications

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“…Regarding NSAID effect overall, our results are coherent with those reported in 10 out of 16 case-control studies [6–8, 16–22], while the remaining six studies did not show any effect [23–28]. Results from 13 cohort studies hardly support any NSAID effect on breast cancer risk; only four reported protective effects [3, 4, 29, 30], seven did not find any association [5, 31–35], and three reported an increase in breast cancer risk [36–38].…”

Section: Discussionsupporting

confidence: 91%

Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

Dierssen-Sotos

Gómez‐Acebo

Pedro³

et al. 2016

BMC Cancer

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BackgroundThe relationship between non-steroidal anti-inflammatory drug (NSAID) consumption and breast cancer has been repeatedly studied, although the results remain controversial. Most case-control studies reported that NSAID consumption protected against breast cancer, while most cohort studies did not find this effect. Most studies have dealt with NSAIDs as a whole group or with specific drugs, such aspirin, ibuprofen, or others, but not with NSAID subgroups according to the Anatomical Therapeutic Chemical Classification System; moreover, scarce attention has been paid to their effect on different tumor categories (i.e.: ductal/non-ductal, stage at diagnosis or presence of hormonal receptors).MethodsIn this case-control study, we report the NSAID – breast cancer relationship in 1736 breast cancer cases and 1895 healthy controls; results are reported stratifying by the women’s characteristics (i.e.: menopausal status or body mass index category) and by tumor characteristics.ResultsIn our study, NSAID use was associated with a 24 % reduction in breast cancer risk (Odds ratio [OR] = 0.76; 95 % Confidence Interval [CI]: 0.64–0.89), and similar results were found for acetic acid derivatives, propionic acid derivatives and COXIBs, but not for aspirin. Similar results were found in postmenopausal and premenopausal women. NSAID consumption also protected against hormone + or HER2+ cancers, but not against triple negative breast cancers. The COX-2 selectivity showed an inverse association with breast cancer (i.e. OR < 1), except in advanced clinical stage and triple negative cancers.ConclusionMost NSAIDs, but not aspirin, showed an inverse association against breast cancer; this effect seems to be restricted to hormone + or HER2+ cancers.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-016-2692-4) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

Dierssen-Sotos

Gómez‐Acebo

Pedro³

et al. 2016

BMC Cancer

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“…In Taiwan, patients who continue dialysis for more than 90 days all apply a catastrophic illness registration card, which ensures the accuracy of our definition of dialysis continuation. The verification of ESRD on chronic dialysis includes a detailed exclusion of acute kidney injury; supported medical records, examination reports, and imaging studies with a comprehensive review by nephrology specialists are required [28]. …”

Section: Methodsmentioning

confidence: 99%

Ketoanalogues supplementation decreases dialysis and mortality risk in patients with anemic advanced chronic kidney disease

Yang

Hung

et al. 2017

PLoS ONE

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BackgroundThe benefit of alpha-Ketoanalogues (KA) supplementation for chronic kidney disease (CKD) patients that followed low-protein diet (LPD) remains undetermined.MethodsWe extracted longitudinal data for all CKD patients in the Taiwan National Health Insurance from January 1, 2000 through December 31, 2010. A total of 1483 patients with anemic advanced CKD treated with LPD, who started KA supplementation, were enrolled in this study. We analyzed the risks of end stage renal disease and all-cause mortality using Cox proportional hazard models with influential drugs as time-dependent variables.ResultsA total of 1113 events of initiating long-term dialysis and 1228 events of the composite outcome of long-term dialysis or death occurred in patients with advanced CKD after a mean follow-up of 1.57 years. Data analysis suggests KA supplementation is associated with a lower risk for long-term dialysis and the composite outcome when daily dosage is more than 5.5 tablets. The beneficial effect was consistent in subgroup analysis, independent of age, sex, and comorbidities.ConclusionsAmong advanced CKD patients that followed LPD, KA supplementation at an appropriate dosage may substantially reduce the risk of initiating long-term dialysis or of developing the composite outcome. KA supplementation represents an additional therapeutic strategy to slow the progression of CKD.

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“…The NHRI database is one of the largest and most comprehensive databases in the world and has been used extensively in various studies on prescription use, diagnoses, and hospitalizations. 13 – 15 …”

Section: Methodsmentioning

confidence: 99%

The Impact of Acute Kidney Injury on the Long‐term Risk of Stroke

Wu²,

et al. 2014

JAHA

132

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BackgroundThe incidence of acute kidney injury (AKI) requiring dialysis in hospitalized patients is increasing; however, information on the long‐term incidence of stroke in patients surviving to discharge after recovering from AKI after dialysis has not been reported.Methods and ResultsPatients that survived after recovery from dialysis‐requiring AKI during index hospitalizations from 1999 to 2008 were identified in nationwide administrative registries. The risk of de novo stroke and death were analyzed with time‐varying Cox proportional hazard models. The results were validated by a critical care database. We enrolled 4315 patients in the AKI‐recovery group (men, 57.7%; mean age, 62.8±16.8 years) and matched 4315 control subjects as the non‐AKI group by propensity scores. After a median follow‐up period of 3.36 years, the incident stroke rate was 15.6 per 1000 person‐years. The AKI‐recovery group had higher risk (hazard ratio: 1.25; P=0.037) and higher severity of stroke events than the non‐AKI group, regardless of progression to subsequent chronic kidney disease. The rate of incident stroke was not statistically different in those with diabetes alone (without AKI) and in those with AKI alone (without diabetes) after hospital discharge (P=0.086). Furthermore, the risk of mortality in the AKI‐recovery group was higher than in the non‐AKI group (hazard ratio: 2.4; P<0.001).ConclusionsThe patients who recovered from AKI had a higher incidence of developing incident stroke and mortality than the patients without AKI, and the impact was similar to diabetes. Our results suggest that a public health initiative is needed to enhance postdischarge follow‐up of renal function and to control the subsequent incidence of stroke among patients who recover from AKI after dialysis.

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Nonsteroidal anti-inflammatory drug use is associated with cancer risk reduction in chronic dialysis patients

Cited by 22 publications

References 41 publications

Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

Ketoanalogues supplementation decreases dialysis and mortality risk in patients with anemic advanced chronic kidney disease

The Impact of Acute Kidney Injury on the Long‐term Risk of Stroke

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