Nonsteroidal Anti-inflammatory Drugs

Buvanendran, Asokumar

doi:10.1007/978-1-4614-1560-2_3

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Cited by 2 publications

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“…In general, COX-1 is thought to be beneficial to the body's homeostasis with functions including maintenance of mucosal epithelium integrity, thus, its inhibition readily leads to gastric ulcers (Buvanendran, 2012). Inhibition of COX-2 only could decrease production of prostanoids such as PGE 2 and PGI 2 that are just involved in inflammatory and pathological processes, as well as ameliorate pain generation (Agarwal et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

A Brief Overview of the Coxib Drugs in the Veterinary Field

Kim

Giorgi

2013

American Journal of Animal and Veterinary Sciences

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Section: Introductionmentioning

confidence: 99%

A Brief Overview of the Coxib Drugs in the Veterinary Field

Kim

Giorgi

2013

American Journal of Animal and Veterinary Sciences

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Stress-Induced Pain: A Target for the Development of Novel Therapeutics

Johnson

Meerveld

2014

J Pharmacol Exp Ther

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Although current therapeutics provide relief from acute pain, drugs used for treatment of chronic pain are typically less efficacious and limited by adverse side effects, including tolerance, addiction, and gastrointestinal upset. Thus, there is a significant need for novel therapies for the treatment of chronic pain. In concert with chronic pain, persistent stress facilitates pain perception and sensitizes pain pathways, leading to a feed-forward cycle promoting chronic pain disorders. Stress exacerbation of chronic pain suggests that centrally acting drugs targeting the pain-and stress-responsive brain regions represent a valid target for the development of novel therapeutics. This review provides an overview of how stress modulates spinal and central pain pathways, identifies key neurotransmitters and receptors within these pathways, and highlights their potential as novel targets for therapeutics to treat chronic pain.

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Nonsteroidal Anti-inflammatory Drugs

Cited by 2 publications

References 74 publications

A Brief Overview of the Coxib Drugs in the Veterinary Field

A Brief Overview of the Coxib Drugs in the Veterinary Field

Stress-Induced Pain: A Target for the Development of Novel Therapeutics

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