Nonsteroidal antiinflammatory drug-photosensitized formation of pyrimidine dimer in DNA

Chouini–Lalanne, Nadia; Defais, Martine; Paillous, Nicole

doi:10.1016/s0006-2952(97)00511-x

Cited by 61 publications

(66 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…34 Furthermore, carbonyl compounds may in principle react with alkenes to form oxetane derivatives through a [2+2] 40 photocycloaddition (Paterno-Büchi reaction). This process is favoured when i) the triplet energy of the alkene is comparable to (or higher than) that of the carbonyl compound and ii) the lowest lying carbonyl triplet state is of n  nature.…”

Section: With Pyrimidinesmentioning

confidence: 99%

“…Another interesting dimeric pyrimidine lesion corresponds to 40 the most abundant UV photoproduct in bacterial spores. 85,86 Indeed, 5-thyminyl-5,6-dihydrothymine adduct, the so called spore photoproduct (Fig.…”

Section: Spore Photoproductsmentioning

confidence: 99%

“…Thus, studies performed on animals (opossum, 4 fish, 5 mice 6 ) suggest that it provokes the formation of papillomas, squamous cell 35 carcinomas (SCC) and melanomas; however, the role played by UVA-mediated oxidative damage to DNA in melanoma induction, using xiphophorus fishes as model, has been recently questioned. 5,7 While UVB is efficiently absorbed by the nucleobases, 40 causing direct photoreactions of DNA, UVA-induced damage is commonly the result of photosensitisation. Thus, modifications in DNA may occur after light absorption by endogenous or exogenous chromophores present in drugs, cosmetic agents, metabolites, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Similar results are obtained when two Thy units are kept in close proximity through a polymethylene linker. 62 The largest 40 Thy<>Thy yield is obtained in the case of Thy-(CH 2 ) 3 -Thy, likely because the angle between the two Thy approaches that in DNA. Only the intramolecular photodimerisation of some N-acetylated dinucleotides gives rise exclusively to the transsyn configuration, presumably due to steric hindrance.…”

mentioning

confidence: 99%

“…Thus, a photosensitiser (Phs) is excited upon light absorption and then transfers its energy to a pyrimidine base, giving rise to thymine or cytosine excited 40 states (Thy * or Cyt * ). These states are able to react with ground state Thy or Cyt leading to the final products (Schemes 1 and 2).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Photosensitised pyrimidine dimerisation in DNA

et al. 2011

View full text Add to dashboard Cite

aTriplet-mediated pyrimidine (Pyr) dimerisation is a key process in photochemical damage to DNA. 5It may occur in the presence of a photosensitiser, provided that a number of requirements are fulfilled, such as favourable intersystem crossing quantum yield and high triplet energy. The attention has been mainly focused on cyclobutane pyrimidine dimers, as they are by far the most relevant Pyr photoproducts obtained by sensitisation. The present perspective deals with the involved chemistry, not only in DNA but also in its simple building blocks. It also includes the 10 photophysical characterisation of the Pyr triplet excited states, as well as a brief discussion of the theoretical aspects.

show abstract

Section: With Pyrimidinesmentioning

confidence: 99%

Section: Spore Photoproductsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Photosensitised pyrimidine dimerisation in DNA

et al. 2011

View full text Add to dashboard Cite

show abstract

Ketones of Six to Thirteen Carbons

O’Donoghue

2023

Patty's Toxicology

View full text Add to dashboard Cite

Ketones of carbon number 6–13 are important commercial and industrial materials. Their primary use is as solvents that find use in numerous products and industrial applications. Due to their volatility, environmental regulations have been directed at restricting emissions, particularly to the atmosphere. A number of the ketones discussed in this chapter not only can undergo photochemical transformations that contribute to their abiotic degradation but may also contribute to the formation of smog. Regulations limiting or prohibiting release of materials that may contribute to smog formation are leading to reductions in the use of some of these materials. The ketones covered in this chapter are mainly of concern due to inhalation and dermal exposure routes. Acute exposure to high vapor concentrations of these materials may result in narcosis; however, such exposures are rare except in cases of accidents. Repeated exposure to certain of these ketones may result in peripheral neuropathy or hepatic effects.

show abstract

Ketones of Six To Thirteen Carbons

Topping¹,

Morgott²,

O’Donoghue³

2001

Patty's Toxicology

View full text Add to dashboard Cite

Ketones of carbon number 6–13 are important commercial and industrial materials. Their primary use is as solvents that find use in numerous products and industrial applications. Due to their volatility, environmental regulations have been directed at restricting emissions, particularly to the atmosphere. A number of the ketones discussed in this chapter can undergo photochemical transformations that contribute to their abiotic degradation but may also contribute to the formation of smog. Regulations limiting or prohibiting release of materials that may contribute to smog formation are leading to reductions in the use of some of these materials. As for the short‐chain ketones discussed in Chapter 75, the ketones covered in this chapter are mainly of concern due to inhalation and dermal exposure routes. Acute exposure to high vapor concentrations of these materials may result in narcosis; however, such exposures are rare except in cases of accidents. Low levels of exposure to many of these ketones can be expected in the environment and through endogenous exposure because ketones are common substrates for many of the enzymes associated with intermediary metabolism in organisms from bacteria to man.

show abstract

Nonsteroidal antiinflammatory drug-photosensitized formation of pyrimidine dimer in DNA

Cited by 61 publications

References 29 publications

Photosensitised pyrimidine dimerisation in DNA

Photosensitised pyrimidine dimerisation in DNA

Ketones of Six to Thirteen Carbons

Ketones of Six To Thirteen Carbons

Contact Info

Product

Resources

About