Nonsteroidal Antiinflammatory Drugs

Haldane, Sarah

doi:10.1016/b978-1-4557-0306-7.00076-3

Cited by 4 publications

(14 citation statements)

References 61 publications

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“…The calculated doses presumably ingested in our case series (70 and 217 mg/kg) have been associated with gastrointestinal ulceration, acute tubular necrosis, liver toxicity, and neurological derangement 5 . In cases of severe intoxication, decontamination using conventional methods of emesis and oral activated charcoal may not be sufficient to prevent severely elevated carprofen levels in the blood 1,4,17 . In the cases reported here, the magnitude of the ingested doses and presence of clinical signs associated with carprofen toxicity were indications to attempt extracorporeal decontamination therapy.…”

Section: Discussionmentioning

confidence: 85%

Efficacy of a single session in‐series hemoperfusion and hemodialysis in the management of carprofen overdose in two dogs

Fick

Messenger

Vigani

2020

J Vet Emergen Crit Care

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Objective To describe the efficacy of in‐series hemoperfusion and hemodialysis in 2 dogs with carprofen overdose. Case Summary This report describes the treatment of 2 dogs following accidental carprofen overdoses who underwent a single in‐series hemoperfusion and hemodialysis session. Serial serum carprofen concentrations were measured before, during, and after the session. The first patient's session lasted 5 hours, with the largest decrease in serum carprofen concentrations occurring during the first hour of treatment. The carprofen clearance during the following 4 hours of treatment decreased substantially compared to the first hour and was not different from the patient's intrinsic clearance of carprofen after the session was completed. Based on the findings from the first case, the second patient was treated with a 1 hour single hemoperfusion and hemodialysis session. Our results support the hypothesis that carprofen is not effectively removed by conventional hemodialysis and the efficacy of hemoperfusion is short lived due to rapid saturation of the charcoal filter. Once filter saturation occurs, the extracorporeal session is no longer efficacious. Using in‐series hemoperfusion and hemodialysis is of benefit to correct the side effects seen with hemoperfusion alone, and hourly charcoal filter replacement may extend the efficacy of treatment in removing carprofen. New or Unique Information Provided This is the first published report of in‐series hemoperfusion and hemodialysis being used to treat carprofen overdose in a dog. In these 2 cases, the intrinsic clearances of the patients were shown to be equivalent to that of standard hemodialysis alone, indicating that hemodialysis does not produce any advantage in carprofen clearance. In this limited report, we suggest that the efficacy of hemoperfusion in removing carprofen is short‐lived, and extending the treatment beyond the first hour does not produce any therapeutic benefit. In order to extend the efficacy of hemoperfusion, hourly replacement of the charcoal filter should be considered.

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Section: Discussionmentioning

confidence: 85%

Efficacy of a single session in‐series hemoperfusion and hemodialysis in the management of carprofen overdose in two dogs

Fick

Messenger

Vigani

2020

J Vet Emergen Crit Care

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“…In dogs and cats, GI ulceration is likely after single exposures exceeding 50 mg/kg within a few hours of exposure . Doses of more than 100 mg/kg have been associated with the development of acute kidney injury in dogs …”

Section: Introductionmentioning

confidence: 99%

Treatment of ibuprofen intoxication in a dog via therapeutic plasma exchange

Walton

Ryan

Davis

et al. 2017

J Vet Emergen Crit Care

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“…Treatment of NSAID overdose typically consists of gastrointestinal decontamination (GID) using a combination of emesis and activated charcoal (AC) . These decontamination methods have been proven to cause a reduction in plasma carprofen concentration .…”

Section: Introductionmentioning

confidence: 99%