Nonstoichiometric wollastonite bioceramic scaffolds with core-shell pore struts and adjustable mechanical and biodegradable properties

Jin, Zhouwen; Wu, Ronghuan; Shen, Jianhua; Yang, Xianyan; Shen, Miaoda; Xu, Wangqiong; Zhang, Lei; Gao, Yang; Gao, Changyou; Gou, Zhongru; Xu, Sanzhong

doi:10.1016/j.jmbbm.2018.08.018

Cited by 18 publications

(15 citation statements)

References 34 publications

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“…Studies have shown that magnesium ions can accelerate bone healing and development by promoting osteoblast adhesion and differentiation; therefore, Mg‐substituted bioceramics can be recently developed in bone defect repair (Nabiyouni et al., 2018; Rao et al., 2018). Our previous studies have demonstrated that CSi, when incorporated with magnesium, has the ability to tailor biodegradation rate, enhance mechanical strength, and even promote angiogenesis and osteogenesis (Jin et al., 2018; Liu et al., 2016; Sun et al., 2016a).…”

Section: Introductionmentioning

confidence: 99%

3D printed bioceramic scaffolds: Adjusting pore dimension is beneficial for mandibular bone defects repair

Qin

Wei

Han

et al. 2022

J Tissue Eng Regen Med

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Bioceramic scaffolds for repairing mandibular bone defects have considerable effects, whereas pore architecture in porous scaffolds on osteogenesis in specific structures is still controversial. Herein 6 mol% magnesium‐substituted calcium silicate scaffolds were fabricated with similar porosity (∼58%) but different cylindrical pore dimensions (Ø 480, 600, and 720 μm) via digital light processing‐based three‐dimensional (3D) printing technique. The mechanical properties, bioactive ion release, and bio‐dissolution of the bioceramic scaffolds were evaluated in vitro, and the facilitation of scaffolds on bone formation was investigated after implanting in vivo. The results showed that as the pore dimension increased, the scaffolds indicated similar surface microstructures, but their compressive strength was enhanced gradually. There was no significant difference in vitro bio‐dissolution between the 480 and 600 μm groups, whereas the 720 μm group showed a much slower dissolution and ion release. Interestingly, the two‐dimensional/three‐dimensional (2D/3D) micro‐CT reconstruction analysis of rabbits' mandibular bone defects model showed that the 600 μm group exhibited evidently higher ratio of the newly formed bone volume to total volume (BV/TV) and trabecular number (Tb. N) values and lower ratio of the scaffolds residual volume to total volume (RV/TV) compare to the other two sizes. Furthermore, the histological analysis also revealed a considerably higher new bone ingrowth rate in the 600 μm group than the other two groups at 4–12 weeks post‐implantation. Totally, it is proved from these experimental studies that the DLP‐based accurately fabricated calcium (Ca) silicate bioceramic scaffolds with appropriate pore dimensions (i.e., 600 μm in pore size) are promising to guide new bone ingrowth and thus accelerate the regeneration and repair of cranial maxillofacial or periodontal bone defects.

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Section: Introductionmentioning

confidence: 99%

3D printed bioceramic scaffolds: Adjusting pore dimension is beneficial for mandibular bone defects repair

Qin

Wei

Han

et al. 2022

J Tissue Eng Regen Med

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“…Jin et al . [ 92 ] doped calcium silicate powders with different mass fractions of Mg ions and used a bilayer printing ( Figure 2C ), and its compressive strength increased from 11.2 MPa to 39.4 MPa and 80 MPa with the increase of Mg ions content. To achieve higher osteoinductivity of bioceramic materials, Alksne et al .…”

Section: Scaffold Filament Structurementioning

confidence: 99%

“…(B) Schematic diagram of scaffold printing by LBL method[ 91 ]. Reprinted with permission from Shao H, Ke X, Liu A, et al , Biofabrication,2017; 9(2):025003, ©Copyright 2021 IOP Publishing (C) Schematic diagram of cell-carrying α-TCP/collagen scaffold printing[ 92 ]. (Reprinted from Journal of the European Ceramic Society, 36, Shao H, He Y, Fu J, et al , 3D printing magnesium-doped wollastonite/β-TCP bioceramics scaffolds with high strength and adjustable degradation, 1495-1503, Copyright (2016) with permission from Elsevier).…”

Section: Scaffold Filament Structurementioning

confidence: 99%

“…Jin et al . [ 92 ] prepared a calcium silicate core-shell structure scaffold containing different mass fractions of Mg ions by a coaxially aligned bilayer nozzle device ( Figure 4D ), and the presence of Mg increased the compressive strength of the scaffold from 39.4 MPa (CSi-Mg4) to 80 MPa (CSi-Mg10), and the degradation rate of CSi-Mg10 after 6 weeks was only 4.3%. Hong et al .…”

Section: Scaffold Filament Structurementioning

confidence: 99%

“…[ 103 ] licensed under Creative Commons Attribution 4.0 license). (D) Schematic diagram of the CSi+PVA+Metal ion core-shell structure scaffold[ 92 ]. (Reprinted from Journal of the European Ceramic Society, 36, Shao H, He Y, Fu J, et al , 3D printing magnesium-doped wollastonite/β-TCP bioceramics scaffolds with high strength and adjustable degradation, 1495-1503, Copyright (2016), with permission from Elsevier) (E) Printed schematic of the GelMA-loaded dual-cell scaffold[ 104 ].…”

Section: Scaffold Filament Structurementioning

confidence: 99%

See 2 more Smart Citations

Advances in Filament Structure of 3D Bioprinted Biodegradable Bone Repair Scaffolds

Lin¹,

Wang²,

Huang³

et al. 2024

IJB

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Conventional bone repair scaffolds can no longer meet the high standards and requirements of clinical applications in terms of preparation process and service performance. Studies have shown that the diversity of filament structures of implantable scaffolds is closely related to their overall properties (mechanical properties, degradation properties, and biological properties). To better elucidate the characteristics and advantages of different filament structures, this paper retrieves and summarizes the state of the art in the filament structure of the three-dimensional (3D) bioprinted biodegradable bone repair scaffolds, mainly including single-layer structure, double-layer structure, hollow structure, core-shell structure and bionic structures. The eximious performance of the novel scaffolds was discussed from different aspects (material composition, ink configuration, printing parameters, etc.). Besides, the additional functions of the current bone repair scaffold, such as chondrogenesis, angiogenesis, anti-bacteria, and anti-tumor, were also concluded. Finally, the paper prospects the future material selection, structural design, functional development, and performance optimization of bone repair scaffolds.

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Core-shell-typed selective-area ion doping wollastonite bioceramic fibers enhancing bone regeneration and repair in situ

Wang

Shen

et al. 2023

Applied Materials Today

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Nonstoichiometric wollastonite bioceramic scaffolds with core-shell pore struts and adjustable mechanical and biodegradable properties

Cited by 18 publications

References 34 publications

3D printed bioceramic scaffolds: Adjusting pore dimension is beneficial for mandibular bone defects repair

3D printed bioceramic scaffolds: Adjusting pore dimension is beneficial for mandibular bone defects repair

Advances in Filament Structure of 3D Bioprinted Biodegradable Bone Repair Scaffolds

Core-shell-typed selective-area ion doping wollastonite bioceramic fibers enhancing bone regeneration and repair in situ

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