Nonsurgical Interventions for Peyronie's Disease: Update as of 2016

Joice, Gregory; Burnett, Arthur L.

doi:10.5534/wjmh.2016.34.2.65

Cited by 13 publications

(9 citation statements)

References 57 publications

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“…Peyronie's Disease (PD) is defined as an acquired fibrosis within the tunica albuginea, usually causing deformity, pain and erectile dysfunction (ED) ( 1 ). The prevalence of PD in the general male population ranges between 3 and 9% ( 2 ). It is considerably higher than the prevalence reported in the past decade, because social stigma prevents many patients from seeking medical care.…”

Section: Introductionmentioning

confidence: 99%

Sonographic patterns of Peyronie's disease in patients with absence of palpable plaques

Dell’Atti

Galosi

2018

Int. braz j urol.

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PurposeNon-palpable isolated septal plaques of the penis are likely present in a significant number of patients affected by erectile dysfunction (ED) and penile pain without deformity or curvature. The aim of this study was to evaluate the ultrasound (US) patterns observed in patients investigated for ED or penile pain without curvature.Materials and MethodsWe reviewed the medical records of 386 patients who underwent an initial colour-Doppler ultrasonography (CDU) of the penis for DE and/or penile pain without curvature. After satisfying inclusion criteria, 41 patients were individualized. All patients had a non-palpable plaque with involvement of the penile septum. Three US patterns were identified: focal hyperecoic thickening of the intercavernosum septum (IS) with acoustic shadow (pattern 1), non-calcified thickening (isoechoic or slightly hyperechoic (pattern 2), and microcalcifications in the IS without associated acoustic shadow (pattern 3).ResultsPatients’ mean age was 51.3±16.7. ED was the predominant disorder in 73.2% of patients, followed by penile pain and length loss in 19.5% and 7.3% of patients, respectively. 32(78.1%) patients showed the pattern 1, 6 (14.6%) pattern 2, and 3 (7.3%) pattern 3. Plaques size varied from 3 to 13 mm. The penile hemodynamic response to CDU reported abnormal findings distally to the septal plaques in 20 patients (<25cm/sec). Median left and right cavernosum artery flows measured a peak systolic velocity of 31cm/sec and 33 cm/sec, respectively.ConclusionsWe believe that an US study with CDU provides a way to characterize, localize, and deliver treatment choice in patients with Peyronie's Disease.

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Section: Introductionmentioning

confidence: 99%

Sonographic patterns of Peyronie's disease in patients with absence of palpable plaques

Dell’Atti

Galosi

2018

Int. braz j urol.

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“…Although the etiology of PD is not fully delineated, an inflammatory process and subsequent aberrant wound healing following repeated trauma to the penis during intercourse are known to be involved in fibrotic processes [ 3 4 ]. Despite promising results with intralesional injection of collagenase clostridium histolyticum [ 5 ], surgical intervention is still the only curative treatment modality that corrects penile deformities [ 6 7 ]. Therefore, the identification of novel therapeutic target involved in complex fibrogenic process of PD is required.…”

Section: Introductionmentioning

confidence: 99%

Silencing Histone Deacetylase 7 Alleviates Transforming Growth Factor-β1-Induced Profibrotic Responses in Fibroblasts Derived from Peyronie's Plaque

Kang

Yin

Choi

et al. 2018

World J Mens Health

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PurposeEpigenetic modifications, such as histone acetylation/deacetylation and DNA methylation, play a crucial role in the pathogenesis of inflammatory disorders and fibrotic diseases. The aim of this study was to study the differential gene expression of histone deacetylases (HDACs) in fibroblasts isolated from plaque tissue of Peyronie's disease (PD) or normal tunica albuginea (TA) and to examine the anti-fibrotic effect of small interfering RNA (siRNA)-mediated silencing of HDAC7 in fibroblasts derived from human PD plaque.Materials and MethodsFor differential gene expression study, we performed reverse-transcriptase polymerase chain reaction for HDAC isoforms (1–11) in fibroblasts isolated from PD plaque or normal TA. Fibroblasts isolated from PD plaque were pretreated with HDAC7 siRNA (100 pmol) and then stimulated with transforming growth factor-β1 (TGF-β1, 10 ng/mL). Protein was extracted from treated fibroblasts for Western blotting. We also performed immunocytochemistry to detect the expression of extracellular matrix proteins and to examine the effect of HDAC2 siRNA on the TGF-β1-induced nuclear translocation of Smad2/3 and myofibroblastic differentiation.ResultsThe mRNA expression of HDAC2, 3, 4, 5, 7, 8, 10, and 11 was higher in fibroblasts isolated from PD plaque than in fibroblasts isolated from normal TA tissue. Knockdown of HDAC7 in PD fibroblasts inhibited TGF-β1-induced nuclear shuttle of Smad2 and Smad3, transdifferentiation of fibroblasts into myofibroblasts, and abrogated TGF-β1-induced production of extracellular matrix protein.ConclusionsThese findings suggest that specific inhibition of HDAC7 with RNA interference may represent a promising epigenetic therapy for PD.

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“…Usually, it happens in the setting of an erect penis during vigorous sex, masturbation, falls, forceful manipulation, and direct trauma (2). In literature, PT is widely thought to be an important etiology for PD (3)(4)(5). PD is defined as a chronic benign fibrotic alteration of the penis of unknown etiology, characterized by the development of plaques or nodules.…”

Section: Case Reportmentioning

confidence: 99%

Ultrasound findings of ruptured Peyronie’s plaque: Case report and review of the literature

Dell’Atti

Galosi

2017

Arch Ital Urol Androl

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We present here a rare case of rupture of tunica albuginea and corpus cavernosum, in the site of a Peyronie's plaque, which happened in a 61-year-old man during a vacuum cleaner masturbation. Ultrasound study showed an irregular hyperechoic defect at the cavernosal rupture site in correspondence of the Peyronie's plaque. The hematoma was evacuated, partially plaque excised, and the tear repaired. Ultrasonography is an ideal technique for evaluating patients with penile trauma and can be routinely used in an emergency. It is a non-invasive method that gives faster results than cavernosography and Magnetic Resonance Imaging.KEY WORDS: Peyronie's disease; Penile trauma; Plaque; Ultrasound; Masturbation. high-frequency (7-12.0 MHz) linear transducer. The exact location of the tear has been demonstrated as an interruption of the thin echogenic line of the tunica albuginea and showed an association of hematoma outside dorsal side of the corpora cavernosa (Figure 1). Color-Doppler ultrasound revealed some vascularity at the periphery of the lesion, however the corpus spongiosum was intact, and vascular structures appeared to have a normal flow. After the informed consent process, the patient was subjected to surgery. The hematoma was evacuated, partially plaque excised, and the tear repaired with prolene 3/0. In the setting of a dorsal curvature, a short full-thickness vertical incision was made on the ventral shaft tunic opposite the area of maximum curvature, which was then closed transversely to shorten the ventral aspect and correct the curvature. An artificial erection created with intracavernosal injection of normal saline showed an intact repair with no leakages and angulations. The wound was closed with 3/0 vicryl. Duration of hospital stay was 2 days after surgery. After 10 weeks, the patient was able to be sexually active as before. Follow-up with patient occurred every 3 months for 15 months, and did not show any significant angulations of penis.

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Nonsurgical Interventions for Peyronie's Disease: Update as of 2016

Cited by 13 publications

References 57 publications

Sonographic patterns of Peyronie's disease in patients with absence of palpable plaques

Sonographic patterns of Peyronie's disease in patients with absence of palpable plaques

Silencing Histone Deacetylase 7 Alleviates Transforming Growth Factor-β1-Induced Profibrotic Responses in Fibroblasts Derived from Peyronie's Plaque

Ultrasound findings of ruptured Peyronie’s plaque: Case report and review of the literature

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