Nonsurgical Periodontal Treatment Options and Their Impact on Subgingival Microbiota

Abstract

Background: Different periodontal treatment methods (quadrant-wise debridement, scaling and root planing (Q-SRP), full-mouth scaling (FMS), full-mouth disinfection (FMD), and FMD with adjuvant erythritol air-polishing (FMDAP)) were applied in periodontitis patients (stage III/IV). The study objective (substudy of ClinicalTrials.gov Identifier: NCT03509233) was to compare the impact of treatments on subgingival colonization. Methods: Forty patients were randomized to the treatment groups. Periodontal parameters and subgingival colonization were evaluated at baseline and 3 and 6 months after treatment. Results: Positive changes in clinical parameters were recorded in every treatment group during the 3-month follow-up period, but did not always continue. In three groups, specific bacteria decreased after 3 months; however, this was associated with a renewed increase after 6 months (FMS: Porphyromonas gingivalis; FMD: Eubacterium nodatum, Prevotella dentalis; and FMDAP: uncultured Prevotella sp.). Conclusions: The benefit of all clinical treatments measured after 3 months was associated with a decrease in pathogenic bacteria in the FMS, FMD, and FMDAP groups. However, after 6 months, we observed further improvement or some stagnation in clinical outcomes accompanied by deterioration of the microbiological profile. Investigating the subgingival microbiota might help appraise successful periodontal treatment and implement individualized therapy.

The expression and clinical significance of miR-30b-3p and miR-125b-1-3p in patients with periodontitis

“…These findings were similar to a previous research to some extent, indicating patients with periodontitis showed lower level of miR-1226 in GCF than healthy controls, and a negative correlation was found between miR-1226 expression, PPD, CAL, and BOP [18]. Nonsurgical periodontal treatments, including quadrant-wise debridement, scaling and root planning, full-mouth scaling, full-mouth disinfection (FMD), FMD with adjuvant erythritol air-polishing, and drug therapies were applied in periodontitis patients, with the purpose to improve both clinical and microbiologic outcomes [38,39]. With regard to the therapeutic implications exerted by clinical significance of miR-30b-3p and miR-125b-1-3p in periodontitis, as previously reported [40], tetramethylpyrazine is a promising agent and its anti-inflammatory and anti-apoptotic effects achieved by targeting miR-302b confer a protection to periodontal ligament stem cells from injuries induced by periodontitis.…”

Advances in Hydrogels for Periodontitis Treatment

“…The primary clinical therapies for periodontitis aimed at eliminating the plaque biofilm include mechanical scaling/root planing and surgical intervention. 8 However, irregular periodontal pockets, high technical sensitivity, and difficulty of operation have hindered these methods from achieving satisfactory results. 9 The systemic adjuvant administration of antibiotics can improve the effectiveness of mechanical therapy.…”

Impact of facemasks on the mouth as an emerging dental concern: A survey among residents of Karachi

“…This includes hydroxide, methylmercaptan, dimethylsulfide, and other sulfur-containing compounds these compounds are produced by the Gram-negative and anaerobic bacteria that cause periodontal disease. 16 , 17 , 18 , 19 , 20 , 21 …”