Nonsurround, nonuniform, biventricular-capable direct cardiac compression provides Frank-Starling recruitment independent of left ventricular septal damage

Mau, James; Menzie, Stuart; Huang, Yifei; Ward, Michael R.; Hunyor, Stephen N.

doi:10.1016/j.jtcvs.2010.05.057

Cited by 11 publications

(4 citation statements)

References 37 publications

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“…First, direct effects on the myocardial region where pressure is applied, and second, a circumferential effect caused by the 3D changes during inflation of two or three support units. This observation is supported by Mau et al, 7 who reported that cavity volume reduction was achieved because the septal-lateral short-axis change exceeded the anterior-posterior lengthening.…”

Section: Discussionsupporting

confidence: 61%

“…This is an important observation as Mau et al stated that "heart surrounding configuration … is likely to constrain ventricular filling and impair early diastolic relaxation." 7 In fact, our results showed a trend toward a decrease in time constants of the PV loops dp/dt min and τ during mechanical support (see Figure, Supplemental Digital Content, http:// links.lww.com/ASAIO/A186). Customization also enabled correct positioning of the implants in a minimally invasive procedure on the beating heart, ensuring correct positioning of the pneumatic units in their predefined locations.…”

Section: Discussionmentioning

confidence: 61%

“…Some extravascular devices were intended to compressing the ventricles of the heart using pneumatic or hydraulic expandable units positioned inside the pericardial space. [5][6][7][8] These devices were mainly investigated in the scope of acute heart failure (HF) animal models. However, promising results have clearly shown the potential of this technology in five human patients with cardiogenic shock.…”

mentioning

confidence: 99%

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Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model

et al. 2018

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For treatment of advanced heart failure, current strategies include cardiac transplantation or blood-contacting pump technology associated with complications, including stroke and bleeding. This study investigated an individualized biventricular epicardial augmentation technology in a drug-induced porcine failing heart model. A total of 11 pigs were used, for the assessment of hemodynamics and cardiac function under various conditions of support pressures and support durations (n = 4), to assess device positioning and function by in vivo computer tomographic imaging (n = 3) and to investigate a minimally invasive implantation on the beating heart (n = 4). Support pressures of 20-80 mm Hg gradually augmented cardiac function parameters in this animal model as indicated by increased left ventricular stroke volume, end-systolic pressures, and decreased end-diastolic pressures. Strong evidence was found regarding the necessity of mechanical synchronization of support end with the isovolumetric relaxation phase of the heart. In addition, the customized, self-expandable implant enabled a marker-guided minimally invasive implantation through a 4 cm skin incision using fluoroscopy. Correct positioning was confirmed in computer tomographic images. Continued long-term survival investigations will deliver preclinical evidence for further development of this concept.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 61%

mentioning

confidence: 99%

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Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model

et al. 2018

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“…This design allowed the two patch chambers to be controlled independently so that compression intensity and frequency could be customized for each ventricle. [28,50] An ECG was used to synchronize the movement of the device with the heart. Potential limitations of the HeartPatch include delamination of the patches from the cardiac surface and the rupture of the heart muscle.…”

Section: Direct Cardiac Compression Devicesmentioning

confidence: 99%

Robotic Cardiac Compression Device Using Artificial Muscle Filaments for the Treatment of Heart Failure

Phan,

Davies,

Hoang

et al. 2023

Advanced Intelligent Systems

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Heart failure occurs when the heart cannot pump adequate blood to the body, which afflicts over 60 million people worldwide. Its treatment options include physiotherapy, medication, mechanical heart support, heart surgery, or heart transplantation. Ventricular assist devices have direct blood contact while passive ventricular constraint devices have only modest therapeutic efficacy. Current direct cardiac compression devices are either bulky, require noisy driving pneumatic sources, or are unable to mimic the natural heart motion. This study introduces a robotic cardiac compression device made of soft artificial muscle filaments that can simultaneously produce radial, axial, and torsional movements, potentially augmenting the pumping function of a failing heart. An empirical model is developed to describe the device motion and an artificial pericardium is employed to enable uniform force distribution to the heart and real‐time pressure sensing. The proposed device could deliver a stroke volume of 70 mL at 15 beats per minute, or a cardiac output of 1.05 L min−1, and achieve a peak instantaneous flow rate of 2.8 L min−1 and an output pressure of 50 mmHg. The new devices are highly customizable and experimentally validated with fresh porcine heart. They are expected to inspire future development of nonblood‐contacting cardiac assist devices.

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Devices that Enhance the Biomechanics of the Failing Heart

Rosalia

Saeed

Roche

2022

Advances in Cardiovascular Technology

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Nonsurround, nonuniform, biventricular-capable direct cardiac compression provides Frank-Starling recruitment independent of left ventricular septal damage

Cited by 11 publications

References 37 publications

Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model

Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model

Robotic Cardiac Compression Device Using Artificial Muscle Filaments for the Treatment of Heart Failure

Devices that Enhance the Biomechanics of the Failing Heart

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