Nonsynergic Effect of Ethanol and Lead on Heme Metabolism in Rats

Santos, José Luis; Fontanellas, Antonio; Morán, María; Salamanca, R. Enrȷquez de

doi:10.1006/eesa.1999.1774

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Our toads were sampled from the field; that origin of the animals may explain the fact that the blood of non-injected control animals contained some amount of the metal, even after keeping them for 2 weeks in metal-free media; it is reasonable to expect that chronically exposed animals would have developed adaptive mechanisms to compensate for negative metal impacts. Similar findings of control non-exposed or non-injected experimental groups containing measurable metal concentrations were reported by other authors (Stansley and Roscoe, 1996;Bergdahl et al, 1998;Santos et al, 1999;Berzins and Bundy, 2002). The amount of lead found in the blood of our control toads may be attributed to a complex process of environmental pollution previous to their capture on the field.…”

Section: Discussionsupporting

confidence: 92%

Effect of lead acetate on the in vitro engulfment and killing capability of toad (Bufo arenarum) neutrophils

Rosenberg

Fink

Arrieta

et al. 2003

Comparative Biochemistry and Physiology Part C: Toxicology &

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Lead is an element of risk for the environment and human health and has harmful effects that may exceed those of other inorganic toxicants. The immune system is one of the targets of lead. Its immunomodulatory actions depend on the level of exposure, and it has been demonstrated that environmental amounts of the metal alter immune function. Very little information is available regarding the effect of the metal on different aspects of the immune system of lower vertebrates, in particular of amphibians. The aim of this study was to investigate the effect of sublethal lead (as acetate) on the function of polymorphonuclear cells of Bufo arenarum. The results revealed that phagocytic and lytic functions of the adherent blood cells collected from sublethal lead-injected toads and incubated with suspensions of Candida pseudotropicalis were affected negatively. The decrease of the phagocytic activity was correlated with increased blood lead levels (P < 0.0001). Additional information referred to the total and differential leukocyte counts was presented; the only difference found was in the number of blast-like cells that resulted augmented in the samples of lead-injected toads. It was concluded that the evaluation of these parameters might be a reliable tool for the biological monitoring of the immune status of amphibians.

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Section: Discussionsupporting

confidence: 92%

Effect of lead acetate on the in vitro engulfment and killing capability of toad (Bufo arenarum) neutrophils

Rosenberg

Fink

Arrieta

et al. 2003

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…Thus, in the absence of heme, the gluconeogenic program is elevated. The well described effect of lead in the inhibition of heme biosynthetic enzymes [ 104 , 105 ] (described above) raises the possibility that lead exposure leads to elevated gluconeogenesis by reducing the suppressive effect of Rev-erb-α on gluconeogenic gene expression.…”

Section: Molecular Mechanisms By Which Lead Might Promote Diabetesmentioning

confidence: 99%

Diabetes and Exposure to Environmental Lead (Pb)

Leff

Stemmer

Tyrrell

et al. 2018

Toxics

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Although the increased incidence of type 2 diabetes since the 1950s is thought to be primarily due to coincident alterations in lifestyle factors, another potential contributing factor in industrialized countries is exposure of the population to environmental pollutants and industrial chemicals. Exposure levels of many environmental toxicants have risen in the same time-frame as the disease incidence. Of particular interest in this regard is the metal lead. Although overall lead exposure levels have diminished in recent decades, there is an under-recognized but persistent occurrence of lead exposure in poor underserved urban populations. Although the neural developmental pathologies induced by lead exposures have been well documented, very little is known about the effect of lead exposure on the incidence of chronic metabolic diseases such as type 2 diabetes. Although our understanding of the metabolic health effects of lead exposure is incomplete, there are studies in model systems and a small amount of epidemiological data that together suggest a deleterious effect of environmental lead exposure on metabolic health. This article reviews the human, animal and in vitro studies that have examined the effects of lead exposure on the development of diabetes and related metabolic conditions.

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Hematological Effects of Lead in Human Populations

Mushak¹

2011

Trace Metals and Other Contaminants in the Environment

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Nonsynergic Effect of Ethanol and Lead on Heme Metabolism in Rats

Cited by 4 publications

References 26 publications

Effect of lead acetate on the in vitro engulfment and killing capability of toad (Bufo arenarum) neutrophils

Effect of lead acetate on the in vitro engulfment and killing capability of toad (Bufo arenarum) neutrophils

Diabetes and Exposure to Environmental Lead (Pb)

Hematological Effects of Lead in Human Populations

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