Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping

Abstract

The stretchable and active multielectrode array successfully measured electrocardiography of rat during blood exposure.

Design of Polymeric Biomaterials: The “Intermediate Water Concept”

“…Compared with other parameters affecting protein adsorption and cell adhesion, intermediate water contents cover a larger range of material functions in hydrated conditions. Intermediate water is a strong contender to contribute novel insights for the study of biocompatible/inert/non-fouling/stealth, selective protein adsorption/cell adhesion and separation systems (Figure 18), 158,159 tissue engineering scaffolds, 160162 and multi-functional smart biomaterials for flexible/stretchable electro devices 163,164 in the near future.…”

Polymer-based flexible bioelectronics

“…For the current studies on bioelectronic devices, the same type of signals has been in fact detected at different sites in vivo [40]. It is generally tried to find the same site of a rat or mouse based on the experiment accumulations, while it is not accurate.…”

“…3d, ii). For the third method, a multielectrode array was fabricated on honeycomb grid-typed Parylene C substrate to become stretchable with good non-thrombogenicity and stability for living rat hearts [40] (Fig. 3d, iii).…”

Biosensors Based on Mechanical and Electrical Detection Techniques

“…Miniaturisation has also led to increased applications of these sensors as arrays, to detect multiple analytes, or in applications demanding a small scale [ 215 ]. One of the drawbacks of FETs is that whilst suitable for short term in vitro application, they are sensitive to environmental change, and not always biocompatible, so have not yet been made functional for long term in vitro use [ 216 , 217 ].…”