Nontraumatic Elevation of Prostate Specific Antigen Following Cardiac Surgery and Extracorporeal Cardiopulmonary Bypass

Hagood, Paul G.; Parra, Raul O.; Rauscher, Judy A.

doi:10.1016/s0022-5347(17)32301-7

Cited by 31 publications

(43 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hagood et al [1] claimed that elevation of PSA due to cardiac surgery involving CPB is unrelated to urethral catheterization; however, we cannot comment on this because diffi cult urethral catheterization was an exclusion criterion in our study.…”

Section: Discussionmentioning

confidence: 76%

“…Netto et al [3] observed no serum PSA rise in patients who underwent cardiac surgery without extracorporeal cardiopulmonary circulation. Hagood et al [1] have claimed that elevated serum PSA could be a marker for operative prostatic ischemia and prostatic infarction, and may help predict the development of urethral stricture and acute urinary retention postoperatively. Coker et al [2] reached the same conclusion, and pointed to the possible role of this process in prostatism.…”

Section: Discussionmentioning

confidence: 99%

“…Coker et al [2] reached the same conclusion, and pointed to the possible role of this process in prostatism. Furthermore, the high prevalence of urethral stricture in men who have undergone cardiovascular surgery is accepted as evidence of ischemia of the pelvic area [1,13] .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated that cardiac surgery involving cardiopulmonary bypass (CPB) leads to elevated serum levels of prostate-specifi c antigen (PSA) [1][2][3] . In surgical interventions that involve temporary clamping of the aorta, such as abdominal aneurysm repair and coronary artery bypass grafting, there is reduced blood fl ow to the lower body during the procedure.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Does Ischemia-Induced Prostate Damage during Cardiac Surgery Involving Cardiopulmonary Bypass Cause Bladder Outlet Obstruction?

Güvel¹,

Türköz

Eğilmez³

et al. 2005

Urol Int

View full text Add to dashboard Cite

Objective: This study sought to investigate whether ischemia-induced prostate damage during cardiac surgery involving cardiopulmonary bypass causes bladder outlet obstruction. Materials and Methods: The study involved 37 men who underwent elective cardiac surgery involving cardiopulmonary bypass. Prostate-specific antigen (PSA) levels were determined preoperatively (baseline) and on postoperative days 1, 5, and 30. In 4 cases, the PSA level after the operation was unchanged from the preoperative level, so these 4 men were excluded from the study. In the remaining 33 patients, symptoms of bladder outlet obstruction were assessed using the International Prostate Symptom Score. Each subject completed this test preoperatively and 3, 6 and 9 months postoperatively, and the means scores at these time points were compared. The effects of patient age, operative time, CPB time, and aortic clamping time on postoperative increases in PSA levels were investigated. Results: Thirty-three (89.2%) of the 37 men exhibited increased postoperative PSA levels compared to baseline. The mean PSA level for the 33 cases on day 5 was significantly higher than the baseline mean, but the mean levels on postoperative days 1 and 30 were comparable to baseline. Nine (24.3%) of the 33 men had postoperative PSA levels greater than 4.0 ng/dl (the upper normal limit). There was no significant difference between preoperative and postoperative International Prostate Symptom Scores. Conclusion: The study indicates that men’s PSA levels are, indeed, increased after cardiac surgery with cardiopulmonary bypass. However, in 9 months of follow-up, there was no association between this PSA rise and development of BOO, according to International Prostate Symptom Scores.

show abstract

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does Ischemia-Induced Prostate Damage during Cardiac Surgery Involving Cardiopulmonary Bypass Cause Bladder Outlet Obstruction?

Güvel¹,

Türköz

Eğilmez³

et al. 2005

Urol Int

View full text Add to dashboard Cite

show abstract

“…13 Markedly elevated PSA concentrations were associated with urinary retention, following cardiac surgery and extracorporeal cardiopulmonary bypass. 14 Semjonow and associates reported up to a 6-fold (mean 2.4-fold) increase in PSA concentrations in seven patients with acute urinary retention following cardiac surgery and cardiopulmonary bypass. 15 The increased serum PSA concentration in these patients decreased over the 48 h following suprapubic cystostomy and relief of their retention.…”

Section: Introductionmentioning

confidence: 95%

Validity of PSA, free/total PSA ratio and complexed/total PSA ratio measurements in men with acute urinary retention

Sriprasad

Dew

Muir

et al. 2001

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

The reliability of serum prostate specific antigen (PSA) measurements in men with acute urinary retention is unclear. Total PSA, free and complexed PSA were measured, and the free/total (f/t) PSA and complexed/total (c/t) PSA ratios calculated, prior to catheterisation and at 48 and 72 h post-catheterisation in 39 men with acute retention. Subsequent histology showed 12 patients had prostate cancer and 27 benign prostatic hypertrophy. Serum free and total PSA fell following catheterisation, while complexed PSA rose during the first 48 h then subsequently fell. The f/t PSA and c/t PSA ratios provided the best discrimination at 48 -72 h with 100% sensitivity and 75 -82% specificity. Prostate Cancer and Prostatic Diseases (2001) 4, 167-172.

show abstract

Ischemic damage to the prostate during cardiac surgery: A clinical model

et al. 1997

View full text Add to dashboard Cite

Nontraumatic Elevation of Prostate Specific Antigen Following Cardiac Surgery and Extracorporeal Cardiopulmonary Bypass

Cited by 31 publications

References 12 publications

Does Ischemia-Induced Prostate Damage during Cardiac Surgery Involving Cardiopulmonary Bypass Cause Bladder Outlet Obstruction?

Does Ischemia-Induced Prostate Damage during Cardiac Surgery Involving Cardiopulmonary Bypass Cause Bladder Outlet Obstruction?

Validity of PSA, free/total PSA ratio and complexed/total PSA ratio measurements in men with acute urinary retention

Ischemic damage to the prostate during cardiac surgery: A clinical model

Contact Info

Product

Resources

About