1982
DOI: 10.1177/030098588201907s02
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Nontuberculous Mycobacterial Disease In Rhesus Monkeys

Abstract: Abstract. In a colony of rhesus monkeys (Macaca mulatta), 42 cases of nontuberculous mycobacterial-related disease were identified from 1970 to 1978. The disease affected young and old colony-born and wild-caught monkeys of both sexes. Serotypes 1, 2, 4, 8, and 18 of the Mycobacterium avium-intracellulare group were isolated from different monkeys. The lesions were primarily intestinal in 36 monkeys. Lesions of the large intestine, small intestine, and mesenteric lymph nodes were characterized by diffuse accum… Show more

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Cited by 33 publications
(16 citation statements)
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“…These two complexes have some important differences in the clinical signs, response to tuberculin testing, and histopathologic findings that can assist in the differentiation between these two entities. MTB complex readily causes clinical disease in otherwise healthy NHP, while MA complex is usually asymptomatic in animals that are immunocompetent, although clinical disease of the gastrointestinal (GI) and reticuloendothelial systems has been reported in SIV‐infected macaques [5, 6, 9]. Clinical signs of MTB complex can affect multiple body systems and may include weight loss, inappetance, failure to thrive, or hepatic/GI disease.…”
Section: Discussionmentioning
confidence: 99%
“…These two complexes have some important differences in the clinical signs, response to tuberculin testing, and histopathologic findings that can assist in the differentiation between these two entities. MTB complex readily causes clinical disease in otherwise healthy NHP, while MA complex is usually asymptomatic in animals that are immunocompetent, although clinical disease of the gastrointestinal (GI) and reticuloendothelial systems has been reported in SIV‐infected macaques [5, 6, 9]. Clinical signs of MTB complex can affect multiple body systems and may include weight loss, inappetance, failure to thrive, or hepatic/GI disease.…”
Section: Discussionmentioning
confidence: 99%
“…The PrimaTB STAT-PAK assay demonstrated high positive and negative predictive values, correctly identifying 90% of the animals in the infected group and 99% of the animals in the control group. Importantly, the test did not have any cross-reactivity with serum samples from monkeys inoculated with M. avium or M. kansasii, the species known to be involved in non-TB mycobacterioses in NHP that can produce false-positive tuberculin skin test reactions (15,17,19).…”
Section: Discussionmentioning
confidence: 99%
“…In spite of rigorous testing and import quarantine measures, outbreaks of TB in NHP continue to occur in research laboratories, resulting in the destruction of numerous valuable animals in the United States and elsewhere (14, 32). Many healthy primates are also euthanized unnecessarily because of false-positive skin test reactions that might be due to a nonspecific inflammatory response to MOT or because of sensitization with cross-reactive nonpathogenic species of environmental mycobacteria (10,15,17,19). Thus, alternative diagnostic approaches for antemortem TB testing of NHP are urgently needed.…”
mentioning
confidence: 99%
“…Infections by MAl in SIV-infected macaques tend to be disseminated; however, the intestines are most frequently involved (HOLMBERG et al 1982) . Grossly, the intestinal wall is thickened and lymphatics are corded and mesenteric lymph nodes are greatly enlarged (Fig.…”
Section: Bacterial and Fungal Infectionsmentioning
confidence: 99%