Nontuberculous Mycobacterial Keratitis

Bullington, Robert H.

doi:10.1001/archopht.1992.01080160097041

Cited by 70 publications

(10 citation statements)

References 30 publications

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“…Several reports of keratitis due to M. abscessus were described (65,105,132,142,158), and the organism was identified to species. Other authors only identified their isolates as M. chelonae (or the former term M. chelonei), but from the text (susceptibility patterns), we were able to differentiate the organisms as M. abscessus (23,103,108). Additionally, Bullington et al (23) did an extensive review of the literature involving keratitis with nontuberculous mycobacteria from 1965 to 1992.…”

Section: Corneal Infections (Keratitis)mentioning

confidence: 82%

“…Other authors only identified their isolates as M. chelonae (or the former term M. chelonei), but from the text (susceptibility patterns), we were able to differentiate the organisms as M. abscessus (23,103,108). Additionally, Bullington et al (23) did an extensive review of the literature involving keratitis with nontuberculous mycobacteria from 1965 to 1992. He found that 21 of 38 (55%) isolates were M. fortuitum, 16 of 38 (42%) were M. chelonae-abscessus group, and 1 (2%) was identified only as group IV mycobacteria (92).…”

Section: Corneal Infections (Keratitis)mentioning

confidence: 82%

“…Almost half of the patients required some type of surgical intervention including keratoplasty, keratoectomy, corneal graft, and several surgical debridement procedures (23).…”

Section: Corneal Infections (Keratitis)mentioning

confidence: 99%

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Clinical and Taxonomic Status of Pathogenic Nonpigmented or Late-Pigmenting Rapidly Growing Mycobacteria

2002

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The history, taxonomy, geographic distribution, clinical disease, and therapy of the pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria (RGM) are reviewed. Community-acquired disease and health care-associated disease are highlighted for each species. The latter grouping includes health care-associated outbreaks and pseudo-outbreaks as well as sporadic disease cases. Treatment recommendations for each species and type of disease are also described. Special emphasis is on the Mycobacterium fortuitum group, including M. fortuitum, M. peregrinum, and the unnamed third biovariant complex with its recent taxonomic changes and newly recognized species (including M. septicum, M. mageritense, and proposed species M. houstonense and M. bonickei). The clinical and taxonomic status of M. chelonae, M. abscessus, and M. mucogenicum is also detailed, along with that of the closely related new species, M. immunogenum. Additionally, newly recognized species, M. wolinskyi and M. goodii, as well as M. smegmatis sensu stricto, are included in a discussion of the M. smegmatis group. Laboratory diagnosis of RGM using phenotypic methods such as biochemical testing and high-performance liquid chromatography and molecular methods of diagnosis are also discussed. The latter includes PCR-restriction fragment length polymorphism analysis, hybridization, ribotyping, and sequence analysis. Susceptibility testing and antibiotic susceptibility patterns of the RGM are also annotated, along with the current recommendations from the National Committee for Clinical Laboratory Standards (NCCLS) for mycobacterial susceptibility testing

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Section: Corneal Infections (Keratitis)mentioning

confidence: 82%

Section: Corneal Infections (Keratitis)mentioning

confidence: 82%

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Clinical and Taxonomic Status of Pathogenic Nonpigmented or Late-Pigmenting Rapidly Growing Mycobacteria

2002

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“…This organism may be incorrectly identified as Corynebacterium or Nocardia species on direct microscopy. 1,2 Corynebacteria are Gram-positive rods that may rarely cause microbial keratitis associated with contact lens wear, 6 whereas Nocardia spp. are Gram-positive, acid-fast ocular pathogens that cause wreathlike corneal infiltrates and should be distinguishable from nontuberculous Mycobacterium by their ability to form true filaments.…”

Section: Discussionmentioning

confidence: 99%

“…1 M. abscessus was previously classified as a subspecies of M. chelonae, a rare cause of indolent ocular infection usually after accidental or surgical trauma and associated with the use of topical corticosteroids. 2,3 Ocular infections include sclerokeratitis, 2 endogenous and exogenous endophthalmitis, 3 crystalline keratopathy, 4 and periocular infections. 5 M. chelonae endophthalmitis has been documented in 3 healthy, immunocompetent adult women with no other infective foci.…”

mentioning

confidence: 99%