Nontypable Haemophilus influenzae Septicemia and Urinary Tract Infection Associated with Renal Stone Disease

Stærk, Marianne; Tolouee, Sara; Christensen, Jens Jørgen

doi:10.2174/1874285801812010243

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Invasive disease had a higher incidence in individuals over 65 years of age, in line with the underlying conditions that are more common in older adults such as COPD, heart disease and diabetes [8,29,30]. By contrast, young adults presented more cases of invasive disease due unusual origins, such as peritonitis, liver abscess, endometritis, facial cellulitis or urinary tract infection, which, although less common, typically affect immunocompetent young adults [31][32][33]. The overall 30 day mortality was 18.0 %, within the range of 10-20 % found in other studies [34][35][36].…”

Section: Discussionmentioning

confidence: 95%

Epidemiology and population structure of Haemophilus influenzae causing invasive disease

et al. 2021

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This study provides an update on invasive Haemophilus influenzae disease in Bellvitge University Hospital (2014–2019), reporting its evolution from a previous period (2008–2013) and analysing the non-typeable H. influenzae (NTHi) population structure using a clade-related classification. Clinical data, antimicrobial susceptibility and serotyping were studied and compared with those of the previous period. Population structure was assessed by multilocus sequence typing (MLST), SNP-based phylogenetic analysis and clade-related classification. The incidence of invasive H. influenzae disease remained constant between the two periods (average 2.07 cases per 100 000 population), while the 30 day mortality rate decreased (20.7–14.7 %, respectively). Immunosuppressive therapy (40 %) and malignancy (36 %) were the most frequent comorbidities. Ampicillin and fluoroquinolone resistance rates had increased between the two periods (10–17.6 % and 0–4.4 %, respectively). NTHi was the main cause of invasive disease in both periods (84.3 and 85.3 %), followed by serotype f (12.9 and 8.8 %). NTHi displayed high genetic diversity. However, two clusters of 13 (n=20) and 5 sequence types (STs) (n=10) associated with clade V included NTHi strains of the most prevalent STs (ST3 and ST103), many of which showed increased frequency over time. Moreover, ST103 and ST160 from clade V were associated with β-lactam resistance. Invasive H. influenzae disease is uncommon, but can be severe, especially in the elderly with comorbidities. NTHi remains the main cause of invasive disease, with ST103 and ST160 (clade V) responsible for increasing β-lactam resistance over time.

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Section: Discussionmentioning

confidence: 95%

Epidemiology and population structure of Haemophilus influenzae causing invasive disease

et al. 2021

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“…Haemophilus spp. is reported as a rare urinary tract pathogen but needs to be investigated in patients with urinary tract abnormalities such as urolithiasis [ 36 ]. A previous study demonstrated that Faecalibacterium was more abundant in patients with diabetes mellitus (DM) and hyperlipidemia, compared to patients with only DM, as seen in the study by Fengping Liu et al They also demonstrated that Faecalibacterium is associated with incidence of UUI.…”

Section: Discussionmentioning

confidence: 99%

The impact of urine microbiota in patients with lower urinary tract symptoms

Lee

Wang

Juan

et al. 2021

Ann Clin Microbiol Antimicrob

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Introduction Inflammation and infection are causative factors of benign prostatic hyperplasia (BPH). Urine is not sterile, and urine microbiota identified by DNA sequencing can play an important role in the development of BPH and can influence the severity of lower urinary tract symptoms (LUTS). Materials and methods We collected mid-stream voided urine samples from BPH patients and control participants and stored them in a freezer at − 80 °C. All enrolled participants were requested to provide information about their clinical characteristics and complete the International Prostate Symptom Score (IPSS) questionnaire. Each step of the procedure, including the extraction of the genomic DNA from the urine samples; the amplification by polymerase chain reaction (PCR); PCR product quantification, mixing, and purification; DNA library preparation; and sequencing was performed with quality control (QC) measures. Alpha diversity was indicative of the species complexity within individual urine samples, and beta diversity analysis was used to evaluate the differences among the samples in terms of species complexity. Pearson’s correlation analysis was performed to calculate the relationship between the clinical characteristics of the participants and the microbiota species in the urine samples. Results We enrolled 77 BPH patients and 30 control participants who reported no recent antibiotic usage. Old age, high IPSS and poor quality of life were observed in the participants of the BPH group. No significant differences were observed in the alpha diversity of the samples. In the beta diversity analysis, there was a significant difference between the microbiota in the samples of the BPH and control groups according to ANOSIM statistical analysis. On comparing the groups, the ten bacterial genera present in the samples of the BPH group in descending order of abundance were: Sphingomonas, Bacteroides, Lactobacillus, Streptococcus, Alcaligenes, Prevotella, Ruminococcaceae UCG-014, Escherichia_Shigella, Akkermansia, and Parabacteroides. Spearman’s correlation analysis revealed that urine samples showing the presence of the bacterial genera Haemophilus, Staphylococcus, Dolosigranulum, Listeria, Phascolarctobacterium, Enhydrobacter, Bacillus, [Ruminococcus]torques, Faecalibacterium, and Finegoldia correlated with a high IPSS, and severe storage and voiding symptoms (P < 0.05). Conclusion Our current study shows that dysbiosis of urine microbiota may be related to the development of BPH and the severity of LUTS. Further research targeting specific microbes to identify their role in the development of diseases is necessary and might provide novel diagnostic biomarkers and therapeutic options.

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“…Overall, pneumonia is the most frequent presentation, with invasive NTHi disease and NTHi pneumonia incidence increasing with age, particularly in older adults with underlying respiratory tract comorbidities, such as COPD and emphysema (204,208). Other clinical presentations, such as epiglottitis (once a characteristic of invasive Hib disease) and skeletal and soft tissue infections, are uncommon, but cholecystitis (209) and urolithiasis (210) appear to be a particular feature of invasive NTHi infection in adults. The morbidity rate of invasive NTHi infections is high in older adults.…”

Section: Nthi Infections In Older Adultsmentioning

confidence: 99%

Invasive Haemophilus influenzae Infections after 3 Decades of Hib Protein Conjugate Vaccine Use

et al. 2021

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Nontypable Haemophilus influenzae Septicemia and Urinary Tract Infection Associated with Renal Stone Disease

Cited by 7 publications

References 20 publications

Epidemiology and population structure of Haemophilus influenzae causing invasive disease

Epidemiology and population structure of Haemophilus influenzae causing invasive disease

The impact of urine microbiota in patients with lower urinary tract symptoms

Invasive Haemophilus influenzae Infections after 3 Decades of Hib Protein Conjugate Vaccine Use

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