Nontyphoidal Salmonella infection among recipients of hematopoietic SCT

Dadwal, Sanjeet; Tegtmeier, Bernard; Nakamura, Ryotaro; Kriengkauykiat, Jane; Ito, James I.; Forman, Stephen J.; Pullarkat, Vinod

doi:10.1038/bmt.2010.204

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…Oslo was the prevalent serovar isolated from patients with malignancy. Dadwal et al [20] reported that D and E were the most common serogroups and serogroups C, V and E were cause of diarrhoea in cancer. In our study, isolates with ser.…”

Section: Discussionmentioning

confidence: 98%

Emergence and serovar profiling of non-typhoidal Salmonellae (NTS) isolated from gastroenteritis cases–A study from South India

Ballal

Devadas

Shetty

et al. 2016

Infectious Diseases

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Human infection with non-typhoidal Salmonella (NTS) serovars is often a neglected and undiagnosed infection in the developing world. Invasive NTS is now being established as having a new and emerging pathogenic role. There is not sufficient data on the prevalence of NTS serovars and their antibiotic susceptibility pattern from India. Faecal specimens collected from patients with acute gastroenteritis were processed to isolate Salmonella according to the standard protocol for a period from January 2011-December 2014. Salmonella isolates were serotyped and tested for antibiotic susceptibility. Of the total 320 (10.04%) bacterial enteric pathogens isolated, 64 (20%) were non-typhoidal Salmonella. Among the serogroup, O:4 (B) (n = 26; 40.6%) was found to be the commonest followed by O:7 (C1) (n = 11; 17.1%) and O:3,10 (E1) (n = 11; 17.1%). NTS infection in cancer patients could also be termed as nosocomial NTS diarrhoea due to primary community infection with prolonged incubation periods, consumption of contaminated food during hospital stay or Nosocomially acquired infection. Serovar Oslo has been predominant (9/17) in NTS isolates from cancer patients, whereas serovars Bovismorbificans, Wangata and Schleissheim have been reported for the first time in the country. The isolates were mostly susceptible to antibiotics except Salmonella ser Kentucky, which showed resistance to ciprofloxacin is reported for the first time in the country. Continuous surveillance is required to monitor resistance of NTS isolates.

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Section: Discussionmentioning

confidence: 98%

Emergence and serovar profiling of non-typhoidal Salmonellae (NTS) isolated from gastroenteritis cases–A study from South India

Ballal

Devadas

Shetty

et al. 2016

Infectious Diseases

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“…Dadwal et al (39) described a retrospective case series of 18 recipients of allogeneic or autologous hematopoietic stem cell transplants, presenting over 15 years. They noted that diarrhoea was absent in 1/3 of cases of iNTS, as is commonly described in immunosuppressed groups.…”

Section: Other Risk Factors For Susceptibility To Invasive Nts Among mentioning

confidence: 99%

Invasive nontyphoidal Salmonella disease

Gordon¹

2011

Current Opinion in Infectious Diseases

165

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Purpose of review-To highlight and discuss important publications over the past 12 months providing new insights on invasive non-typhoidal Salmonella disease (iNTS).Recent findings-There have been informative new estimates of the burden of iNTS in Asia and in high-resource low-incidence settings. Important information has emerged in the last year about the relationships between HIV, malaria, iNTS and typhoid fever in adults and children in Africa. HIV causes susceptibility to iNTS disease, but has been shown to be protective against typhoid fever. Clinical guidelines for presumptive diagnosis frequently fail to identify iNTS disease in Africa, and there remains a need for improved diagnostic tools. Experimental studies in humans have helped us to understand the intracellular pathogenesis of iNTS and to direct the search for appropriate protein vaccine targets.Summary-The most important remaining gap in our knowledge is probably an understanding of how NTS are transmitted, and the nature of the relationship between diarrhoeal disease, carriage and invasive disease in Africa, so that diagnostic and prevention tools can be appropriately directed.

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“…Infectious events occurred even during periods of neutropenia. Case reports in similar populations and one cohort study of non-typhoidal Salmonella spp from a large transplant center 2,3,34,35 also suggest that these findings are not likely isolated to our center.…”

Section: Discussionmentioning

confidence: 68%

“…13,14 Credence for such recommendations is further stunted by a lack of studies addressing the burden of bacterial foodborne infections in HCT recipients. 3,15 More recent data suggests that restrictive nutritional strategies intended to prevent the consumption of pathogenic organisms may in fact increase the risk of infection. 16 …”

Section: Introductionmentioning

confidence: 99%

Bacterial Foodborne Infections after Hematopoietic Cell Transplantation

Boyle

Podczervinski

Jordan

et al. 2014

Biology of Blood and Marrow Transplantation

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Background Diarrhea, abdominal pain and fever are common among patients undergoing hematopoietic cell transplant (HCT), but such symptoms are also typical with foodborne infections. The burden of disease caused by foodborne infections in patients undergoing HCT is unknown. We sought to describe bacterial foodborne infection incidence post-transplant within a single-center population of HCT recipients. Methods All HCT recipients transplanted from 2001 through 2011 at the Fred Hutchinson Cancer Research Center in Seattle, WA were followed for one year post-transplant. Data were collected retrospectively using center databases, which include information from transplant, on-site examinations, outside records, and collected laboratory data. Patients were considered to have a bacterial foodborne infection if Campylobacter jejuni/coli, Listeria monocytogenes, E. coli 0157:H7, Salmonella species, Shigella species, Vibrio species or Yersinia species were isolated in culture within one-year post-transplant. Non-foodborne infections with these agents and patients with preexisting bacterial foodborne infection (within 30 days of transplant) were excluded from analyses. Results A total of 12/4069 (0.3%) patients developed a bacterial foodborne infection within one year post-transplant. Patients with infections had a median age at transplant of 50.5 years (interquartile range [IQR]: 35–57), and the majority were adults ≥18 years of age (9/12 [75%]), male gender (8/12 [67%]) and post-allogeneic transplant (8/12 [67%]). Infectious episodes occurred at an incidence rate of 1.0 per 100,000 patient-days (95% CI: 0.5–1.7) and at a median of 50.5 days after transplant (IQR: 26–58.5). The most frequent pathogen detected was Campylobacter jejuni/coli (5/12 [42%]) followed by Yersinia (3/12 [25%]), while Salmonella (2/12 [17%]) and Listeria (2/12 [17%]) showed equal frequencies; no cases of Shigella, Vibrio, or E. coli 0157:H7 were detected. Most patients were diagnosed via stool (8/12 [67%]), fewer through blood (2/12 [17%]), one via both stool and blood simultaneously, and one through urine. Mortality due to bacterial foodborne infection was not observed during follow-up. Conclusions Our large single-center study indicates that common bacterial foodborne infections were a rare complication following HCT, and the few cases that did occur resolved without complications. These data provide important baseline incidence for future studies evaluating dietary interventions for HCT patients.

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Nontyphoidal Salmonella infection among recipients of hematopoietic SCT

Cited by 9 publications

References 12 publications

Emergence and serovar profiling of non-typhoidal Salmonellae (NTS) isolated from gastroenteritis cases–A study from South India

Emergence and serovar profiling of non-typhoidal Salmonellae (NTS) isolated from gastroenteritis cases–A study from South India

Invasive nontyphoidal Salmonella disease

Bacterial Foodborne Infections after Hematopoietic Cell Transplantation

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