Nonulcer dyspepsia in a Dutch working population and Helicobacter pylori. Ulcer history as an explanation of an apparent association

Abstract

In the Dutch working population, nonulcer dyspepsia is not related to H pylori infection, whereas for duodenal ulcer the relationship is clear. The apparent association between dyspeptic symptoms and H pylori infection is entirely accounted for by subjects with an ulcer history.

Peptic Ulcer Bleeding: Interaction between Non-Steroidal Anti-Inflammatory Drugs,Helicobacter pyloriInfection, and the ABO Blood Group System

“…The H. pylori prevalence in the Dutch population used in this study is derived from serologic data in healthy blood donors (592 persons (12,13)) and 500 factory employees (14). There may be some selection because blood donors are healthy and younger and represent a higher socioeconomic class.…”

“…The prevalence of H. pylori in the Dutch population was determined from the results of 4 seroepidemiologic studies in healthy blood donors (n = 401 (12); n = 191 (13)), in a working population (n = 500) (14), and in 383 patients (without gastrointestinal complaints, a history of peptic ulcer disease, or the use of bismuth, H 2 -receptor antagonists, or proton pump inhibitors) visiting a geriatric outpatient department (15). (See Appendix for detailed data.)…”

The Prevalence and Risk Factors of Functional Dyspepsia in a Multiethnic Population in the United States

“…Hence, extrapolating the findings of referral-based studies to the general population may not be appropriate. Other studies have relied on self-reporting of ulcer disease by patients to make a diagnosis of nonulcer dyspepsia (12,13). However, self-reporting of lesions is not standardized and can be inaccurate.…”

Leitlinien der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten zur Behandlung der Dyspepsie

“…Zur ulkustypischen Symptomatik gehören Schmerzen, die durch Speisen oder Antazida gelindert werden und das Auftreten von Schmerzen vor den Mahlzeiten oder bei Nahrungskarenz. Die Untergruppe refluxtypischer Dys- Patienten, deren Oberbauchsymptome keiner der obigen Untergruppen zugerechnet werden können, werden der Kategorie ¹unspezifische Dyspepsieª zugeordnet [8]. [19,103].…”