Nonuniform mass detection using magnetostrictive biosensors operating under multiple harmonic resonance modes

Li, Suiqiong; Cheng, Z.-Y.

doi:10.1063/1.3431523

Cited by 35 publications

(38 citation statements)

References 30 publications

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“…It is assumed that the shift in the resonance frequency is dependent on the vibration amplitude of the location at which the mass load is attached [4]. Therefore, the sensitivity of an MSP is dependent on the x following Equation (3).…”

Section: Elimination Of "Blind Point(s)"mentioning

confidence: 99%

“…Compared with MSMCs, MSPs have a higher Q values and a better sensitivity. In addition, due to the nature of free standing, an MSP sensor is able to overcome the blind point issue to achieve a higher mass sensitivity [4]. The fundamentals of MSP resonators are studied in this paper.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, magnetostrictive materials based AW devices such as magnetostrictive micro-cantilevers (MSMCs) [2][3][4][5] and free standing magnetostrictive particles (MSPs) [6][7][8][9] as high-performance sensor platforms have introduced. The principal advantage of these magnetostriction based AW devices is that these AW devices and thereafter the biosensors are wireless.…”

Section: Introductionmentioning

confidence: 99%

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Resonance behavior of metallic glass resonators and their application as sensor platform

Zhang

et al. 2011

MRS Proc.

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Utilizing magnetostrictive effect, the metallic glass is used to form mechanical resonators with different configurations. The resonance behaviors of these resonators are studied under different conditions, including different dc magnetic bias fields and different ac magnetic driving field. It is found that the resonators made of metallic glass exhibit a higher quality merit factor. Based on the results, it is also found that the acoustic wave velocity of the metallic glass decreases with increasing frequency. The application of these resonators as sensor platform is investigated. It is found that both odd and even vibration modes can be detected. Therefore, it provides a unique device that is capable to detect the target species on the sensor surface without "blind point(s)", which is a challenge for all sensors based on other types of resonators. For the biosensors based on these resonators, a high sensitivity was observed. The advantages of these sensors over the current devices are demonstrated by the detection of Salmonella typhimurium (S. typhimurium) in water.

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Section: Elimination Of "Blind Point(s)"mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Resonance behavior of metallic glass resonators and their application as sensor platform

Zhang

et al. 2011

MRS Proc.

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“…Li et al and Ramasamy et al investigated the effect of mass load with symmetric distribution on the mass sensitivity of an MSP biosensor. 13,14 In particular, when the mass loading (e.g. bacteria) is applied to the node of resonance (also called "blind point") of an MSP biosensor, zero mass sensitivity is obtained whereas Li et al proposed a way to address the "blind point" issue by measuring multiple order resonance frequencies.…”

Section: Introductionmentioning

confidence: 99%

“…bacteria) is applied to the node of resonance (also called "blind point") of an MSP biosensor, zero mass sensitivity is obtained whereas Li et al proposed a way to address the "blind point" issue by measuring multiple order resonance frequencies. 13 However, there has been little work investigating the mass sensitivity for the mass load with asymmetry distribution. Particularly, for the case of direct detection of bacteria on food surface, the complicated food surface morphology, for example, egg shell surface may lead to asymmetric contact with an MSP based biosensor and thus cause asymmetric binding of bacteria.…”

Section: Introductionmentioning

confidence: 99%

Study of “blind point” and mass sensitivity of a magnetostrictive biosensor with asymmetric mass loading

Zhang

Chai

2014

AIP Advances

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The existence of “blind point” lowers the mass sensitivity and reliability of magnetostrictive particle (MSP) based biosensors. In addition, asymmetric distribution of mass loading (e.g. bacteria) will cause the shift of “blind point” and change of mass sensitivity of an MSP based biosensor. In this work, a modal analysis method was introduced and conducted to derive the governing vibration equation for an MSP biosensor with asymmetric mass loading. The effects of asymmetric mass loading on the “blind point” shift and mass sensitivity were unveiled by solving the governing vibration equation. It was found that the plot of “blind point” shift showed an “M” shape with the valley located at a/l ∼ 0.5 and two peaks located at a/l ∼ 0.25 and a/l ∼ 0.75. In addition, the theoretical results showed that the resonance frequency shift (Δf) depends on the value of a/l (i.e. both the attached mass and mass distribution) and their relationship is nonlinear. Based on the definition of mass sensitivity (Sm), the values of Sm were derived for the selected values of a/l. The results showed that Sm decreased initially with increasing a/l, reaching the minimum, and then increased until a/l = 1. That is, the maximum mass sensitivity is obtained when a/l equals to a critical value Xc (0 < Xc < l). Based on the result, an optimal mass loading distribution design criterion for developing a more sensitive MSP based biosensor was proposed.

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A Review of Piezoelectric and Magnetostrictive Biosensor Materials for Detection of COVID‐19 and Other Viruses

et al. 2020

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fever with or without chills, chest tightness, dry cough, and shortness of breath, while developing patchy to diffuse infiltration of the lungs, as shown radiographically in Figure 1. Identifying and monitoring SARS-CoV-2 infection has become crucially important. A recent projection of the transmission dynamics of SARS-CoV-2 [2] showed that longitudinal serological studies are desperately needed to determine the extent and duration of immunity to SARS-CoV-2. Even in the event of apparent elimination, maintenance of SARS-CoV-2 surveillance is still needed because of a possible resurgence of contagion. In the past, notable viruses have emerged suddenly from obscurity or anonymity, provoking concern from the point of view of immunology regarding their sustained epidemic transmission in naive human populations. More than 70% of these infections have been zoonotic, entering either directly from wild animal reservoirs or indirectly via an intermediate domestic animal host. [3] Ebola virus, avian influenza, human immunodeficiency virus (HIV), and SARS are all examples of zoonoses that have emerged from wild animals, presenting an increasingly serious threat to human health and economies worldwide. Figure 2 shows the trend in the number of people infected with SARS-CoV-2. [4] The spread of the severe acute respiratory syndrome coronavirus has changed the lives of people around the world with a huge impact on economies and societies. The development of wearable sensors that can continuously monitor the environment for viruses may become an important research area. Here, the state of the art of research on biosensor materials for virus detection is reviewed. A general description of the principles for virus detection is included, along with a critique of the experimental work dedicated to various virus sensors, and a summary of their detection limitations. The piezoelectric sensors used for the detection of human papilloma, vaccinia, dengue, Ebola, influenza A, human immunodeficiency, and hepatitis B viruses are examined in the first section; then the second part deals with magnetostrictive sensors for the detection of bacterial spores, proteins, and classical swine fever. In addition, progress related to early detection of COVID-19 (coronavirus disease 2019) is discussed in the final section, where remaining challenges in the field are also identified. It is believed that this review will guide material researchers in their future work of developing smart biosensors, which can further improve detection sensitivity in monitoring currently known and future virus threats.

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Nonuniform mass detection using magnetostrictive biosensors operating under multiple harmonic resonance modes

Cited by 35 publications

References 30 publications

Resonance behavior of metallic glass resonators and their application as sensor platform

Resonance behavior of metallic glass resonators and their application as sensor platform

Study of “blind point” and mass sensitivity of a magnetostrictive biosensor with asymmetric mass loading

A Review of Piezoelectric and Magnetostrictive Biosensor Materials for Detection of COVID‐19 and Other Viruses

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