Nonvalvular myocardial involvement in metastatic carcinoid disease

Abstract

A patient with the unusual post mortem finding ofmyocardial metastatic carcinoid tumour without classical valvular or endocardial carcinoid disease is described. This rare occurrence may represent an aggressive type of carcinoid tumour, with metastatic disease occurring before the development of classical fibrous valvular and endocardial pathology.

Isolated Metastatic Myocardial Carcinoid Tumor in a 48-Year-Old Man

“…2 Aggressive surgical treatment has been reported to benefit some patients. 13 Direct involvement of the myocardium by metastatic carcinoid tumor is rare, with fewer than 15 cases reported in the medical literature, [14][15][16][17][18][19][20][21][22] and may represent a more aggressive process than the better-described valvular carcinoid heart disease. Only one case reported to date 14 had a similar constellation of a solitary RV mass, an ileal primary tumor, and the absence of hepatic involvement or a carcinoid syndrome.…”

Cases in a series of carcinoid syndrome and carcinoid heart disease

“…Metastatic involvement of the myocardium is uncommon; however, it has been reported. 11 The Mayo Clinic previously reported 132 carcinoid syndrome patients, where a total of 74 (56%) patients had echocardiographic evidence suggestive of CHD. A total of 62 (90%) of the 74 patients had moderate to severe tricuspid valve regurgitation and 36 (49%) developed thickened, retracted, immobile pulmonary leaflets.…”