Objective: The aim of this study was to describe the relationship between negative affect (NA), decision-making style, time stress, and decision quality in health care.Background: Health care providers must often make swift, high-stakes decisions. Influencing factors of the decisionmaking process in this context have been understudied.Method: Within a sample of labor and delivery nurses, physicians, and allied personnel, we used self-report measures to examine the impact of trait factors, including NA, decision-making style, and perceived time stress, on decision quality in a situational judgment test (Study 1). In Study 2, we observed the influence of state NA, state decision-making style, state time stress, and their relationship with decision quality on real clinical decisions.Results: In Study 1, we found that trait NA significantly predicted avoidant decision-making style. Furthermore, those who were higher on trait time stress and trait avoidant decision-making style exhibited poorer decisions. In Study 2, we observed associations between state NA with state avoidant and analytical decision-making styles. We also observed that these decision-making styles, when considered in tandem with time stress, were influential in predicting clinical decision quality.Conclusion: NA predicts some decision-making styles, and decision-making style can affect decision quality under time stress. This is particularly true for state factors.Application: Individual differences, such as affect and decision-making style, should be considered during selection. Training to reduce time stress perceptions should be provided.