Nonviral Intercellular Adhesion Molecule-1 Small Interfering Ribonucleic Acid Sequences Transfection In Vivo

Kupatt, Christian

doi:10.1016/j.jacc.2009.10.036

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…The technique has attracted much attention for clinical use in various diseases, and has potential to treat cardiovascular diseases. However, transfection of the endothelium and myocardial cell with siRNAs in vivo still poses a distinct hurdle [67]. There still need a noninvasive and effective method to transfer siRNA into target cells.…”

Section: Gene Therapy Mediated By Utmd In Cardiovascular Diseasementioning

confidence: 99%

Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles

Chen

Lin

Yang

et al. 2013

Cardiovasc Ultrasound

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Gene therapy provides an efficient approach for treatment of cardiovascular disease. To realize the therapeutic effect, both efficient delivery to the target cells and sustained expression of transgenes are required. Ultrasound targeted microbubble destruction (UTMD) technique has become a potential strategy for target-specific gene and drug delivery. When gene-loaded microbubble is injected, the ultrasound-mediated microbubble destruction may spew the transported gene to the targeted cells or organ. Meanwhile, high amplitude oscillations of microbubbles increase the permeability of capillary and cell membrane, facilitating uptake of the released gene into tissue and cell. Therefore, efficiency of gene therapy can be significantly improved. To date, UTMD has been successfully investigated in many diseases, and it has achieved outstanding progress in the last two decades. Herein, we discuss the current status of gene therapy of cardiovascular diseases, and reviewed the progress of the delivery of genes to cardiovascular system by UTMD.

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Section: Gene Therapy Mediated By Utmd In Cardiovascular Diseasementioning

confidence: 99%

Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles

Chen

Lin

Yang

et al. 2013

Cardiovasc Ultrasound

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“…102 Taken together, ultrasound-targeted microbubble destruction may become an important therapeutic tool for treatment of cardiovascular disease, not only for reperfusion injury, but also for anti-inflammatory treatment in atherosclerosis, an inductor of acute myocardial infarction. 103,104 Still, most of the studies using therapeutic gene transfer have been performed in small-animal models. 101 As a next step towards a clinical application, pre-clinical large-animal studies will reveal the therapeutic potential of ultrasonic gene delivery.…”

Section: Novel Techniques 41 Ultrasonic Gene and Drug Deliverymentioning

confidence: 99%

Adjuvant early and late cardioprotective therapy: access to the heart

Hinkel

Boekstegers

Kupatt

2012

Cardiovascular Research

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Coronary heart disease is still the leading cause of death in industrialized nations, occurring either as acute coronary occlusion and myocardial infarction or as chronic ischaemic cardiomyopathy caused by continuous obstruction of one or more coronary arteries. Even after successful reperfusion, an additional loss of otherwise vital cardiomyocytes may occur in the primary ischaemic area, called lethal reperfusion injury. In experimental settings, delivery of therapeutic agents targeting the reperfusion injury reduces the infarct size by 30%. In addition to the choice of therapeutic agent and time point, the mode of application may be crucial for the therapeutic success. Therefore, this review focuses on the current and future administration techniques for early and late post-myocardial infarction therapies.

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