Nootropic, anxiolytic and CNS-depressant studies on different plant sources of<i>shankhpushpi</i>

Malik, Jai; Karan, Maninder; Vasisht, Karan

doi:10.3109/13880209.2011.584539

Cited by 78 publications

(44 citation statements)

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“…Reports have shown that dietary feeding of C. pluricaulis (CP) increases protein synthesis of the hippocampus, thus enhancing memory and learning in experimental animals (Sinha et al, 1989). It has also been found to augment memory function in many behavioral studies (Bihaqi et al, 2011;Malik et al, 2011;Sharma et al, 2010). Methanolic extract of plant also showed acetylcholinesterase inhibitory activity (Vinutha et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…The plant contains alkaloid (Shankhapushpine), volatile oil, flavonoids (kaempferol derivatives), phytosterol (b-sitosterol), carbohydrates, 20-oxodotriacontanol, tetra-triacontanoicacid, 29-oxodotriacontanol and scopoletin (Bisht et al, 1978;Chowdhary & Kapoor, 1986;Deshpande & Srivastava, 1969). The plant has also well reported for its memory enhancing (Bihaqi et al, 2012;Malik et al, 2011;Nahata et al, 2008), neuroprotective (Bihaqi et al, 2009), antidepressant (Dhingra & Valecha, 2007), and antioxidant (Joshi et al, 2004) activities. Therefore, the present study was designed to explore the effect of CP against 3-NP-induced behavioral and oxidative stress alterations in striatum and cortex regions in rat brain.…”

Section: Introductionmentioning

confidence: 99%

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Protective effect ofConvolvulus pluricaulisstandardized extract and its fractions against 3-nitropropionic acid-induced neurotoxicity in rats

Malik

Choudhary

Kumar

2015

Pharmaceutical Biology

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Context: Convolvulus pluricaulis Chois. (Convolvulaceae), a well-known Ayurvedic ''Medhya Rasayana'' (nervine tonic), is extensively used for different central nervous system (CNS) disorders. Objective: The objective of this study was to evaluate the protective effect of standardized hydro-methanol extract of C. pluricaulis (CPE) and its fractions, namely ethyl acetate (EAE), butanol (BE), and aqueous (AE), against 3-nitropropionic acid (3-NP) induced neurotoxicity in rats. Materials and methods: The extract of the whole plant was standardized on the basis of scopoletin content (0.014%) using thin layer chromatography densitometric analysis. CPE (100 and 200 mg/kg) and its fractions, namely EAE (15 and 30 mg/kg), BE (25 and 50 mg/kg), and AE (50 and 100 mg/kg) were administered orally for 20 d. Their protective effect against 3-NP (10 mg/kg, i.p. for 14 d) was assessed by the effect on various behavioral parameters, namely body weight, locomotor activity, grip strength, gait pattern, and the effect on cognitive dysfunction. Biochemical parameters for oxidative damage were also assessed in the striatum and cortex regions of the brain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effect ofConvolvulus pluricaulisstandardized extract and its fractions against 3-nitropropionic acid-induced neurotoxicity in rats

Malik

Choudhary

Kumar

2015

Pharmaceutical Biology

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“…We compared the three plants, viz. CP, E. alsinoides and C. ternatea, commonly used under the name shankhpushpi for various CNS activities (Malik et al 2011). The results of the previous study clearly indicated that CP possessed better activity than the other two plants.…”

Section: Introductionmentioning

confidence: 93%

Attenuating effect of bioactive coumarins fromConvolvulus pluricaulison scopolamine-induced amnesia in mice

Malik

Karan

Vasisht

2015

Natural Product Research

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Convolvulus pluricaulis Chois. (Convolvulaceae) has been used in Ayurveda as Medhya Rasyana (nervine tonic) to treat various mental disorders. This study was designed to isolate the bioactive compound(s) of this plant and to evaluate their effect against scopolamine-induced amnesia. Column chromatography of the chloroform and ethyl-acetate fractions led to the isolation of three coumarins identified as scopoletin, ayapanin and scopolin. All the three compounds at 2.5, 5, 10 and 15 mg/kg, p.o. were evaluated for memory-enhancing activity against scopolamine-induced amnesia using elevated plus maze and step down paradigms. Effect on acetylcholinesterase activity in mice brain was also evaluated. Scopoletin and scopolin, in both the paradigms, significantly and dose dependently attenuated the scopolamine-induced amnesic effect. Furthermore, these compounds at 10 and 15 mg/kg exhibited activity comparable to that of standard drug, donepezil. The compounds also exhibited significant acetylcholinesterase inhibitory activity.

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“…Shankhpushpi is considered as a potential "Nervine tonic" recommended for treating several nervous disorders such as stress, anxiety, mental fatigue, and insomnia 3 . Pre-clinical investigations have demonstrated its memory enhancement, anti-epileptic and immunemodulatory, anti-amnesic, anti-stress (adaptogenic), anti-microbial and gastroprotective properties as well.…”

Section: Introductionmentioning

confidence: 99%

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2017

IJPSR

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Alzheimer's disease is a form of dementia, in which nerve cells in memory areas of brain and eventually other areas begin to die at accelerated rate resulting in serious deterioration in several mental functions such as memory loss, language, orientation and judgment. The main objective of the present study was to investigate and compare the neuro-pharmacological effects of Evolvulus alsinoides plant extract on the cholinergic system and Histopathological aspects in AD-induced rat model. Ethanolic extract of Evolvulus alsinoides Linn (EAE) was prepared and administered to rats orally at a dose of 200 mg/kg body weight. To evaluate the anticholinergic potential of the plant extract, selected regions of the brain viz. Cerebral Cortex, Hippocampus, Pons medulla and cerebellum were used. As a corollary to these, Histopathological experiments only on two selected regions of the brain viz. cerebral cortex and hippocampus were conducted in all groups of rats on 60 th day of experimentation in order to assess the extent of cytoarchitectural changes in neurons brought out by AD induction and the reversal efficiency of EAE. A common observation was made i.e., Evolvulus alsinoides (EAE) extract exhibited a positive stimulatory effect on the cholinergic system in all groups of rats in general and ADinduced rats in particular. This was further reiterated by Histopathological experiments changes in the neurons of cerebral cortex and hippocampus of ADinduced rat brains have been restored back to the near normal condition after administration of EAE to AD-induced rats. In view of this, it was concluded that EAE has neuroprotective effect on cholinergic system which would pave new vistas in the discovery of safe and novel anti-Alzheimer's compounds.

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Nootropic, anxiolytic and CNS-depressant studies on different plant sources ofshankhpushpi

Abstract: The above results showed all the three plants possess nootropic, anxiolytic and CNS-depressant activity. The results of memory-enhancing activity suggest C. pluricaulis to be used as true source of shankhpushpi.

Cited by 78 publications

References 20 publications

Protective effect ofConvolvulus pluricaulisstandardized extract and its fractions against 3-nitropropionic acid-induced neurotoxicity in rats

Protective effect ofConvolvulus pluricaulisstandardized extract and its fractions against 3-nitropropionic acid-induced neurotoxicity in rats

Attenuating effect of bioactive coumarins fromConvolvulus pluricaulison scopolamine-induced amnesia in mice

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