Nootropic Effect of Berberine in Colchicines Induced Experimental Alzheimer's Disease Model: Effect on Cholinergic Neurotransmission

Effect of berberine on cognitive function and β-amyloid precursor protein in Alzheimer’s disease models: a systematic review and meta-analysis

“…In accordance with the developed literature search, a total of 2,741 articles were found in the initial search for the item study strategy, and 1,096 duplicates were excluded through Notexpress literature management software, leaving 1,645 articles to be screened. A total of 1,602 articles were excluded by reading the title and abstract, 23 articles were excluded by reading the full text, and 23 studies were excluded due to the following reasons: incomplete study data; absence of the primary endpoints of our study; cellular experiments rather than animal experiments, and 19 articles were finally included in the final literature ( Zhu and Qian, 2006 ; Bhutada et al, 2011 ; Durairajan et al, 2012 ; Mangrulkar et al, 2013 ; Patil et al, 2015 ; de Oliveira et al, 2016 ; Kumar et al, 2016 ; Chen et al, 2017 ; He et al, 2017 ; Huang et al, 2017 ; Cai et al, 2018 ; Hussien et al, 2018 ; Chen et al, 2020b ; Lin et al, 2020 ; Wang et al, 2021b ; Liang et al, 2021 ; Wu et al, 2021 ; Ye et al, 2021 ; Yang and Wang, 2022 ). The flow diagram of the selection process is shown in ( Figure 1 ).…”

Neuroprotective effects and possible mechanisms of berberine in animal models of Alzheimer’s disease: a systematic review and meta-analysis

“…Subsequently, we thoroughly read the full text of the remaining 75 articles and excluded 53 including non-rodent animal experiments, non-AD models, no cognitive outcomes, AD combined with other models, only abstract and data duplication. Finally, 22 eligible researches ( Zhu and Qian, 2006 ; Durairajan et al, 2012 ; Lee et al, 2012 ; Mangrulkar et al, 2013 ; Haghani et al, 2015 ; de Oliveira et al, 2016 ; Mangrulkar et al, 2016 ; He et al, 2017 ; Huang et al, 2017 ; Cai et al, 2018 ; Hussien et al, 2018 ; Abdel-Latif et al, 2019 ; Cai et al, 2019 ; Chen et al, 2020 ; Lin et al, 2020 ; Liang et al, 2021 ; Raju et al, 2021 ; Saleh et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ; Ye et al, 2021 ; Yang and Wang, 2022 ) were selected for analysis ( Figure 1 ).…”

“…Sprague Dawley (SD) rats were selected in 3 studies ( Zhu and Qian, 2006 ; Lee et al, 2012 ; Hussien et al, 2018 ), of which administering the heavy metal mixture in 1 study ( Hussien et al, 2018 ), intraperitoneal injection of SCO in 1 study ( Lee et al, 2012 ) and injection peptides into the bilateral hippocampus in 1 study ( Zhu and Qian, 2006 ). Swiss Albino mice with ICV injection of colchicine were used in 2 studies ( Mangrulkar et al, 2013 ; Mangrulkar et al, 2016 ). In terms of sex, 14 studies ( Zhu and Qian, 2006 ; Lee et al, 2012 ; Haghani et al, 2015 ; de Oliveira et al, 2016 ; He et al, 2017 ; Cai et al, 2018 ; Cai et al, 2019 ; Liang et al, 2021 ; Raju et al, 2021 ; Saleh et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ; Ye et al, 2021 ; Yang and Wang, 2022 ) used male animals, 2 studies contained both sexes ( Huang et al, 2017 ; Lin et al, 2020 ), only one study ( Hussien et al, 2018 ) used female animals, and 5 studies ( Durairajan et al, 2012 ; Mangrulkar et al, 2013 ; Mangrulkar et al, 2016 ; Abdel-Latif et al, 2019 ; Chen et al, 2020 ) did not report.…”

“…In terms of sex, 14 studies ( Zhu and Qian, 2006 ; Lee et al, 2012 ; Haghani et al, 2015 ; de Oliveira et al, 2016 ; He et al, 2017 ; Cai et al, 2018 ; Cai et al, 2019 ; Liang et al, 2021 ; Raju et al, 2021 ; Saleh et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ; Ye et al, 2021 ; Yang and Wang, 2022 ) used male animals, 2 studies contained both sexes ( Huang et al, 2017 ; Lin et al, 2020 ), only one study ( Hussien et al, 2018 ) used female animals, and 5 studies ( Durairajan et al, 2012 ; Mangrulkar et al, 2013 ; Mangrulkar et al, 2016 ; Abdel-Latif et al, 2019 ; Chen et al, 2020 ) did not report. (2) For administration, 21 studies ( Zhu and Qian, 2006 ; Durairajan et al, 2012 ; Lee et al, 2012 ; Mangrulkar et al, 2013 ; de Oliveira et al, 2016 ; Mangrulkar et al, 2016 ; He et al, 2017 ; Huang et al, 2017 ; Cai et al, 2018 ; Hussien et al, 2018 ; Abdel-Latif et al, 2019 ; Cai et al, 2019 ; Chen et al, 2020 ; Lin et al, 2020 ; Liang et al, 2021 ; Raju et al, 2021 ; Saleh et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ; Ye et al, 2021 ; Yang and Wang, 2022 ) used oral or intragastric administration of berberine, with berberine doses ranging from 5 mg/kg/d to 260 mg/kg/d; one study ( Haghani et al, 2015 ) utilized intraperitoneal injection of berberine at a dose of 50 mg/kg/d. (3) In terms of behavioral outcomes, 21 studies ( Zhu and Qian, 2006 ; Durairajan et al, 2012 ; Lee et al, 2012 ; …”

“… (2) For administration, 21 studies ( Zhu and Qian, 2006 ; Durairajan et al, 2012 ; Lee et al, 2012 ; Mangrulkar et al, 2013 ; de Oliveira et al, 2016 ; Mangrulkar et al, 2016 ; He et al, 2017 ; Huang et al, 2017 ; Cai et al, 2018 ; Hussien et al, 2018 ; Abdel-Latif et al, 2019 ; Cai et al, 2019 ; Chen et al, 2020 ; Lin et al, 2020 ; Liang et al, 2021 ; Raju et al, 2021 ; Saleh et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ; Ye et al, 2021 ; Yang and Wang, 2022 ) used oral or intragastric administration of berberine, with berberine doses ranging from 5 mg/kg/d to 260 mg/kg/d; one study ( Haghani et al, 2015 ) utilized intraperitoneal injection of berberine at a dose of 50 mg/kg/d. (3) In terms of behavioral outcomes, 21 studies ( Zhu and Qian, 2006 ; Durairajan et al, 2012 ; Lee et al, 2012 ; Mangrulkar et al, 2013 ; Haghani et al, 2015 ; de Oliveira et al, 2016 ; Mangrulkar et al, 2016 ; He et al, 2017 ; Huang et al, 2017 ; Cai et al, 2018 ; Hussien et al, 2018 ; Abdel-Latif et al, 2019 ; Chen et al, 2020 ; Lin et al, 2020 ; Liang et al, 2021 ; Raju et al, 2021 ; Saleh et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ; Ye et al, 2021 ; Yang and Wang, 2022 ) performed the Morris water maze (MWM) test. In these studies, 19 studies ( Zhu and Qian, 2006 ; Lee et al, 2012 ; Mangrulkar et al, 2013 ; de Oliveira et al, 2016 ; Mangrulkar et al, 2016 ; ...…”