Noradrenaline: Fate and Control of Its Biosynthesis

Axelrod, Julius

doi:10.1126/science.173.3997.598

Cited by 277 publications

(122 citation statements)

References 75 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…Norepinephrine in the locus coeruleus plays a critical role in arousal (47), attention, memory, mood, and cognition (48). Noradrenergic neurotransmission is terminated by the transport of released NE by the plasma membrane NET (49). Altered cell surface expression of monoamine transporters is a critical mechanism for regulating amine transport, and trafficking of monoamine transporters including that of NET has been shown to occur under basal conditions and following treatment with transporter substrates and inhibitors (51).…”

Section: Discussionmentioning

confidence: 99%

A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference

Padmanabhan

Kamalakkannan

Damaj

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Cocaine-activated p38 MAPK-mediated norepinephrine transporter (NET) threonine 30 phosphorylation up-regulates NET. Results: p38 MAPK inhibition and TAT-NET-Thr 30 peptide blocks cocaine-mediated NET up-regulation and cocaine-induced locomotor sensitization and conditioned place preference (CPP). Conclusion: Blockade of p38 MAPK-mediated Thr30 -dependent NET regulation attenuates cocaine-induced locomotor sensitization, CPP, and CPP reinstatement. Significance: Regulation of NET plays a mechanistic role in cocaine-mediated behaviors.

show abstract

Section: Discussionmentioning

confidence: 99%

A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference

Padmanabhan

Kamalakkannan

Damaj

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…This concept dates to the demonstration by Holger Hyden (1972) of learn ing-dependent activation of specific mRNAs and pro teins in pertinent brain parts; subsequently, this pro cess was shown to occur upon presynaptic stimulation (Axelrod 1971;Costa and Guidotti 1978) . Perhaps the ultimate expression of trans synaptic regulation and the resulting modulation of postsynaptic responses is con stituted by genetic induction; Hyden mentioned this phenomenon, without being able to demonstrate it directly, to explain his findings.…”

Section: Interactions Modulations and Gene Expressionmentioning

confidence: 99%

Brief Presentation of the Story and Present Status of Studies of the Vertebrate Cholinergic System

Karczmar

1993

Neuropsychopharmacol

View full text Add to dashboard Cite

This year marks the seventieth anniversary of Otto Loewi's demonstration of chemical transmission generally and autonomic cholinergic transmission specifically and the fortieth anniversary of John Eccles's proof of the existence of central cholinergic transmission. Following these epochal findings, the subsequent studies of the cholinergic system led to discoveries of similarly important phenomena. This review concerns these phenomena, including chemical structure and molecular biology of cholinergic receptors; electrophysiologic and ionic aspects of pre-and postsynaptic cholinergic events; the quantal expression of cholinergic postsynaptic events and activities of their subunits, the elementary events; and teratology; trophic phenomena; and the clinical aspects of the cholinergic system. This review refers to the history as well as the present status of each of these phenomena; furthermore, it describes briefly the nineteenth-century work with calabar bean, pilocarpine, muscarine, and nicotine, that is, the work performed before the promulgation of the cholinergic era.[ Neuropsychopharmacology 9:181-199, 1993J included the frrst descriptions of the trophic phenomena, the quantal nature of the biological events, the recep tors and their chemical structure, the role of a trans mittive system in arousal and memory, and so on. So, it is appropriate to sketch at this time the history and the present status of the vertebrate cholinergic studies.

show abstract

“…noradrenaline may be incorporated into vesicles in neuronal endings, may be deaminated by MAO (a mitochondrial enzyme which is present in neu rones) in smooth muscle and in endothelial cells (Hardebo and Owman, 1980b), or may be methyl ated by COMT, a cytoplasmic enzyme which is cer tainly present in smooth muscle but probably also occurs in cerebral parenchymal cells (Axelrod, 1971).…”

Section: Discussionmentioning

confidence: 99%

An Inhibitor of Cerebral Uptake of Noradrenaline in Jaundiced Blood Plasma

Bloom

McDowell

1983

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Summary: The permeability of the blood-brain barrier to noradrenaline was estimated in rats with bile duct li gation by intracarotid injection of [14Cl-L-noradrenaline, 3H20, and [ll3mInjethylene diamine tetraacetate (EDTA) under pentobarbitone anaesthesia, Brain uptake of [14Clnoradrenaline was expressed as a percentage of that of 3H20 (brain uptake index, B UI) and corrected for the "blood background" by the 113mIn. The BUI of noradren aline (1.20 ± 0.19) was not increased in jaundice (0.78 ± 0.18). The capacity of oxygenated homogenates of rat Cerebral blood flow is not normally very sensitive to intravascular noradrenaline (Olesen, 1972). This is considered to be due to the inaccessibility of the arteriolar smooth muscle rather than to a lack of receptors, since cerebral vasoconstriction can be induced by microinjection of noradrenaline into the perivascular space of pial arteries (Wahl et aI., 1972) or into the interstitial fluid of the hypothalamus (Cranston and Rosendorff, 1971). On the other hand, intravascular administration, when the cere bral endothelium has been opened by osmotic shock, has caused an increase in cerebral blood flow, probably secondary to an increase in cerebral metabolic rate (Mackenzie et aI., 1976).A moderate reduction in cerebral blood flow was found with intracarotid infusion of noradrenaline (8 or 16 j.Lg min -1 ) in baboons with bile duct ligation (Bloom et aI., 1975). It was suggested that this hy persensitivity to noradrenaline might be due to an

show abstract

Noradrenaline: Fate and Control of Its Biosynthesis

Cited by 277 publications

References 75 publications

A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference

A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference

Brief Presentation of the Story and Present Status of Studies of the Vertebrate Cholinergic System

An Inhibitor of Cerebral Uptake of Noradrenaline in Jaundiced Blood Plasma

Contact Info

Product

Resources

About