Noradrenaline Potentiates Portal Hypertension through the Alpha 2a Adrenergic Receptor – A target for Therapy in Portal Hypertension

Jones, Hannah; Sharma, Vinod; Silva, A.F. Brandao da; Davies, N; Macnaughtan, Jane; Jalan, Rajiv; Mookerjee, RP

doi:10.1016/s0168-8278(16)00739-x

Cited by 3 publications

(3 citation statements)

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“…Moreover, in vitro studies demonstrated that portal vein myocytes in rats and strips of the canine portal vein in dogs contract in response to exposure to alpha 2 adrenergic agonists 22,23 . This may lead to a transient increase in intrahepatic portal vascular resistance and temporary portal hypertension, 24 which has been previously associated with gallbladder wall thickening in humans 25 . This theory is supported by a prior study that demonstrated reduced portal vein velocity as measured ultrasonographically following the administration of dexmedetomidine, producing velocities consistent with portal hypertension 11 .…”

Section: Discussionmentioning

confidence: 99%

Intravenous dexmedetomidine, morphine, or a combination can result in gallbladder wall thickening; with no significant association with plasma histamine concentrations

Bini

Cohen

Chiavaccini

et al. 2022

Vet Radiology Ultrasound

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The gallbladder is routinely evaluated during ultrasonographic examinations in dogs. However, published studies describing the effects of sedative agents on gallbladder wall thickness are currently lacking. The aims of this prospective, blinded, randomized crossover pilot study were to test hypotheses that IV morphine would result in gallbladder wall thickening, that morphine administration would increase plasma histamine concentrations, and that combining IV morphine with dexmedetomidine would potentiate gallbladder wall thickening. Six healthy Beagle dogs were sedated with intravenous (IV) morphine 0.4 mg/kg (group M), dexmedetomidine 7 μg/kg (group D), or a combination of the two (group MD). Physiologic parameters were measured at baseline and at regular intervals until the last ultrasonographic scan. Ultrasonographic scans were performed at baseline, 90 s, and at 5, 15, 30, 45, 60, 90, and 120 min. Plasma histamine samples were taken at baseline, 90 s, and 5 and 60 min. Cochran's Q‐test was used to compare gallbladder wall thickening between groups, while the association between histamine plasma concentration and gallbladder wall thickness was compared with a mixed‐effects model. Baseline gallbladder wall thickness was not significantly different between groups. Six of 18 treatments/dogs (33%) developed gallbladder thickening, with no difference between groups. There was no significant difference in baseline plasma histamine concentrations between groups, and no association between plasma histamine concentration and gallbladder wall thickness. Gallbladder wall thickening was observed in at least one dog in each group, therefore caution is recommended for gallbladder wall thickness ultrasonographic interpretation in dogs when these drugs have been administered.

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Section: Discussionmentioning

confidence: 99%

Intravenous dexmedetomidine, morphine, or a combination can result in gallbladder wall thickening; with no significant association with plasma histamine concentrations

Bini

Cohen

Chiavaccini

et al. 2022

Vet Radiology Ultrasound

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“…Недавно опубликованы результаты применения при экспериментальном холестатическом циррозе нового α2-адреноблокатора BRL44408, который эффективно снижал уровень ПД и не оказывал значительного влияния на системную гемодинамику. Однако данный эффект до настоящего времени получен только на крысах [11,12].…”

Section: результаты и обсуждениеunclassified

Adrenergic Agents in Correction of Portal Hypertension in Cirrhosis of the Liver

Красавцев¹,

Сенникова²

2020

Hepatol Gastroenterol

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Гомельский государственный медицинский университет, Гомель, Беларусь В обзоре приведены современные данные по проблеме профилактики кровотечения из варикозно-расширенных вен пищевода (ВРВП) с помощью различных адренергических средств. Освещены доказательства связи полиморфизмов гена b2-адренорецептора (ADRB2) с более значимым снижением градиента печеночно-венозного давления (ГПВД) в ответ на лечение неселективными бета-адреноблокаторами.

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“…In experimental cholestatic cirrhosis, short-term therapy with the α2 antagonist BRL44408 significantly decreased portal pressure and did not alter systemic haemodynamics even without NSBB cotherapy, which, however, has been published in only two abstracts so far [ 12 , 13 ].…”

Section: Adrenoceptor Drugsmentioning

confidence: 99%

Novel treatment options for portal hypertension

Schwabl

Laleman

2017

Gastroenterology Report

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Portal hypertension is most frequently associated with cirrhosis and is a major driver for associated complications, such as variceal bleeding, ascites or hepatic encephalopathy. As such, clinically significant portal hypertension forms the prelude to decompensation and impacts significantly on the prognosis of patients with liver cirrhosis. At present, non-selective β-blockers, vasopressin analogues and somatostatin analogues are the mainstay of treatment but these strategies are far from satisfactory and only target splanchnic hyperemia. In contrast, safe and reliable strategies to reduce the increased intrahepatic resistance in cirrhotic patients still represent a pending issue. In recent years, several preclinical and clinical trials have focused on this latter component and other therapeutic avenues. In this review, we highlight novel data in this context and address potentially interesting therapeutic options for the future.

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Noradrenaline Potentiates Portal Hypertension through the Alpha 2a Adrenergic Receptor – A target for Therapy in Portal Hypertension

Cited by 3 publications

References 0 publications

Intravenous dexmedetomidine, morphine, or a combination can result in gallbladder wall thickening; with no significant association with plasma histamine concentrations

Intravenous dexmedetomidine, morphine, or a combination can result in gallbladder wall thickening; with no significant association with plasma histamine concentrations

Adrenergic Agents in Correction of Portal Hypertension in Cirrhosis of the Liver

Novel treatment options for portal hypertension

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