Noradrenergic afferents and receptors in the medial preoptic area: Neuroanatomical and neurochemical links between the regulation of sleep and body temperature

Kumar, Velayudhan Mohan; Vetrivelan, Ramalingam; Mallick, Hruda Nanda

doi:10.1016/j.neuint.2007.02.004

Cited by 48 publications

(31 citation statements)

References 66 publications

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“…MPOA is involved in the regulation of several behaviors and physiological parameters as parental behavior sleep and core body temperature (Kumar et al, 2007;Nakamura, 2011;Numan, 2007). In the MPOA, although we observed a significant PER1 increase at the time of FAA, values remain high for the rest of the temporal points and this increase does not persist in fasted subjects.…”

Section: Discussioncontrasting

confidence: 54%

The median preoptic nucleus exhibits circadian regulation and is involved in food anticipatory activity in rabbit pups

Moreno

Meza

Ortega

et al. 2014

Chronobiology International

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Rabbit pups are a natural model to study food anticipatory activity (FAA). Recently, we reported that three areas in the forebrain - the organum vasculosum of lamina terminalis, median preoptic nucleus (MnPO) and medial preoptic area - exhibit activation during FAA. Here, we examined the PER1 protein profile of these three forebrain regions in both nursed and fasted subjects. We found robust PER1 oscillations in the MnPO in nursed subjects, with high PER1 levels during FAA that persisted in fasted subjects. In conclusion, our data indicate that periodic nursing is a strong signal for PER1 oscillations in MnPO and future experiments are warranted to explore the specific role of this area in FAA.

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Section: Discussioncontrasting

confidence: 54%

The median preoptic nucleus exhibits circadian regulation and is involved in food anticipatory activity in rabbit pups

Moreno

Meza

Ortega

et al. 2014

Chronobiology International

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“…It has also been established that hepatic vagal afferents are necessary to promptly convey information from the immune system to the hypothalamus and initiate a fever in response to peripheral LPS exposure (Simons et al, 1998;MohanKumar et al, 2000). In this regard it appears that interleukin-1beta or PGE 2 stimulates the vagus (Li et al, 2006;Wieczorek and Dunn, 2006), and these noradrenergic pathways project from the brainstem through the ventral noradrenergic bundle and synapse in the POAH, where there are numerous noradrenergic terminals (Kumar et al, 2007). Our work suggests that norepinephrine released from these projections may act quickly and directly at alpha-1 ARs to modulate the activity of thermosensitive and insensitive neurons to shift the set-point into a hyperthermic range.…”

Section: Discussionmentioning

confidence: 99%

The effects of Cirazoline, an alpha-1 adrenoreceptor agonist, on the firing rates of thermally classified anterior hypothalamic neurons in rat brain slices

et al. 2008

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Peripheral exposure to LPS induces a biphasic fever thought to be initiated via vagal afferents to the preoptic area of the anterior hypothalamus (POAH), an important thermoregulatory control center in the brain. Previous studies have shown norepinephrine synaptically mediates this Prostaglandin E 2 (PGE 2 )-dependent change in temperature through the selective activation of alpha-2 adrenoreceptors (AR). However, there is clear evidence that alpha-1 AR activation of thermoregulatory hypothalamic neurons will result in a rapid hyperthermia that is not dependent on PGE 2 . This direct action of norepinephrine in the POAH was tested in the present study by recording the single-unit activity of POAH neurons in a tissue slice preparation from the adult male rat, in response to temperature and the selective alpha-1 AR agonist Cirazoline (1−100 μM). Neurons were classified as either warm sensitive or temperature insensitive. Warm sensitive neurons responded to Cirazoline with a decrease in firing rate, while temperature insensitive neurons showed a firing rate increase. These responses are similar to those reported for PGE 2 and suggest that both warm sensitive and temperature insensitive neurons in the POAH are important in mediating this alpha-1 AR dependent hyperthermic shift in body temperature.

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“…In support of this possibility, ingestion of MSG solution enhances diet-induced thermogenesis (47,56). Conceivably, such effects of MSG might involve activation of the peripheral and central nervous systems such as the afferent vagal branches in the gut, the afferent sensory nerves in the oral cavity, and possibly the activation of the medial preoptic area and dorsomedial nucleus of the hypothalamus, the areas activated by intragastric MSG (26)(27)(28)51) and known to be involved in thermoregulation (7,11,29).…”

Section: Food Intake Weight Gain Fat Deposition and Plasma Leptin Lmentioning

confidence: 98%

“…The amygdala is activated by both glucose and MSG. The medial preoptic area and dorsomedial nucleus of the hypothalamus have both been proposed as playing a role in thermoregulation (7,11,29), while the habenular nucleus, especially the lateral habenula, participates in affective decision-making by influencing the activity of midbrain dopaminergic and serotonergic neurons (34). The amygdala is a key structure in the evaluation of the biological significance of foods (38,40).…”

Section: Forebrain Activation By Intragastric Nutrient Administrationmentioning

confidence: 99%

Physiological Significance of Glutamate Signaling in Gut-Brain Communication

Kondoh

Mallick

Torii

2009

Bioscience Microflora

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L-Glutamate is involved in the perception of umami taste, intermediary metabolism, and excitatory neurotransmission. In addition, recent studies have uncovered a variety of physiological roles for dietary glutamate, as evidenced by the fact that intragastric glutamate infusions induce flavor preference learning in rats. Moreover, glutamate increases digestive juice secretion and gastric emptying of protein-rich meals. Glutamate levels in blood and brain remain stable all day long even after the food intake since most of glutamate absorbed is oxidized in the mucosa of the small intestine as a primary energy source. Chronic ad libitum ingestion of glutamate solution contributes to reducing weight gain, fat deposition, and plasma leptin levels in comparison to ingestion of water. Glutamate receptors and their cellular transduction molecules have recently been identified in gut epithelial cells. Stimulation of gut glutamate receptors enhances the apical expression of glutamate transporters and also triggers the release of nitric oxide. Nitric oxide in its turn induces gut serotonin release, which increases vagal afferent inputs to different brain regions. Notably, three brain areas, i.e., the medial preoptic area, the dorsomedial nucleus of the hypothalamus, and the habenular nucleus are activated by intragastric glutamate infusions. Total subdiaphragmatic vagotomy abolishes this response. Consistent with the above, vagotomy specifically reduces the overall intake of glutamate. Taken together, these findings contribute to the growing body of evidence indicating that glutamate signaling via dedicated taste and gut receptors influences multiple physiological functions including gut secretion, motility, digestion, absorption, metabolism and energy homeostasis.

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Noradrenergic afferents and receptors in the medial preoptic area: Neuroanatomical and neurochemical links between the regulation of sleep and body temperature

Cited by 48 publications

References 66 publications

The median preoptic nucleus exhibits circadian regulation and is involved in food anticipatory activity in rabbit pups

The median preoptic nucleus exhibits circadian regulation and is involved in food anticipatory activity in rabbit pups

The effects of Cirazoline, an alpha-1 adrenoreceptor agonist, on the firing rates of thermally classified anterior hypothalamic neurons in rat brain slices

Physiological Significance of Glutamate Signaling in Gut-Brain Communication

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