Noradrenergic effects in tardive dyskinesia, akathisia and pseudoparkinsonism via the limbic system and basal ganglia

Wilbur, Robert; Fa, Kulik; Av, Kulik

doi:10.1016/0278-5846(88)90081-4

Cited by 22 publications

(5 citation statements)

References 32 publications

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“…Similarly, in a previous first-episode study, baseline EPS was associated with poorer treatment response (Chatterjee et al 1995), and tardive dyskinesia has also been associated with less AP efficacy and poorer treatment outcomes (Asher-Svanum et al 2008b). By contrast, akathisia, which may be more related to the noradrenergic transmitter system (Wilbur et al 1988), was not related to ENR or UNR in our or prior studies. Finally, neither we nor Stauffer and colleagues (2011) detected a significant relationship between body weight gain and either ER or UR status.…”

Section: Early Response In Youth Treated With Antipsychoticscontrasting

confidence: 83%

Early Nonresponse Determined by the Clinical Global Impressions Scale Predicts Poorer Outcomes in Youth with Schizophrenia Spectrum Disorders Naturalistically Treated with Second-Generation Antipsychotics

Stentebjerg-Olesen

Jeppesen

Pagsberg

et al. 2013

Journal of Child and Adolescent Psychopharmacology

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Section: Early Response In Youth Treated With Antipsychoticscontrasting

confidence: 83%

Early Nonresponse Determined by the Clinical Global Impressions Scale Predicts Poorer Outcomes in Youth with Schizophrenia Spectrum Disorders Naturalistically Treated with Second-Generation Antipsychotics

Stentebjerg-Olesen

Jeppesen

Pagsberg

et al. 2013

Journal of Child and Adolescent Psychopharmacology

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“…It is also suggested that alpha-adrenergic mechanisms and in particular α2ARs, may be involved in reserpine-induced tremor and rigidity (Colpaert, 1987). In human, akathisia and pseudo-parkinsonian tremor are modulated by a NAergic pathway that projects from the LC to the limbic system (Wilbur et al, 1988); these symptoms are improved by an α2ARs agonist or a βARs antagonist (Wilbur et al, 1988). Several studies have also reported the involvement of the LC NA pathway in freezing (Mizuno et al, 1994; Sandyk, 1996; Ringendahl and Sierla, 1997; Devos et al, 2010), the “on–off” phenomenon (Sandyk, 1996), postural instability (Narabayashi et al, 1991), and akinesia (Hornykiewicz, 1975; Narabayashi et al, 1991).…”

Section: The Locus Coeruleus Noradrenergic System In Pdmentioning

confidence: 99%

“…However, co-administration of idazoxan with l -Dopa can provide an anti-parkinsonian action lasting more than twice the duration obtained with l -Dopa alone. Interestingly, the α2AR agonist clonidine and βARs blockers like propranolol are effective in treating akathisia and tardive dyskinesia (Wilbur et al, 1988). However, clonidine is more often used to treat attention deficit in PD.…”

Section: Therapeutic Approaches Targeting the Naergic Systemmentioning

confidence: 99%

Noradrenaline and Parkinson's Disease

Delaville

Deurwaerdère

Benazzouz

2011

Front. Syst. Neurosci.

191

110

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Parkinson's disease (PD) is characterized by the degeneration of dopamine (DA) neurons in the substantia nigra pars compacta, and motor symptoms including bradykinesia, rigidity, and tremor at rest. These symptoms are exhibited when striatal dopamine concentration has decreased by around 70%. In addition to motor deficits, PD is also characterized by the non-motor symptoms. However, depletion of DA alone in animal models has failed to simultaneously elicit both the motor and non-motor deficits of PD, possibly because the disease is a multi-system disorder that features a profound loss in other neurotransmitter systems. There is growing evidence that additional loss of noradrenaline (NA) neurons of the locus coeruleus, the principal source of NA in the brain, could be involved in the clinical expression of motor as well as in non-motor deficits. In the present review, we analyze the latest evidence for the implication of NA in the pathophysiology of PD obtained from animal models of parkinsonism and from parkinsonian patients. Recent studies have shown that NA depletion alone, or combined with DA depletion, results in motor as well as in non-motor dysfunctions. In addition, by using selective agonists and antagonists of noradrenaline alpha receptors we, and others, have shown that α2 receptors are implicated in the control of motor activity and that α2 receptor antagonists can improve PD motor symptoms as well as l-Dopa-induced dyskinesia. In this review we argue that the loss of NA neurons in PD has an impact on all PD symptoms and that the addition of NAergic agents to dopaminergic medication could be beneficial in the treatment of the disease.

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“…Preliminary evidence of a role of adrenaline and noradrenaline (NA) in parkinsonian tremor emerged from studies published in the 1960s and 1980s (Constas, 1962; Colpaert, 1987; Wilbur et al, 1988). …”

Section: Introductionmentioning

confidence: 99%

A role for locus coeruleus in Parkinson tremor

Isaias¹,

Marzegan²,

Pezzoli³

et al. 2012

Front. Hum. Neurosci.

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We analyzed rest tremor, one of the etiologically most elusive hallmarks of Parkinson disease (PD), in 12 consecutive PD patients during a specific task activating the locus coeruleus (LC) to investigate a putative role of noradrenaline (NA) in tremor generation and suppression. Clinical diagnosis was confirmed in all subjects by reduced dopamine reuptake transporter (DAT) binding values investigated by single photon computed tomography imaging (SPECT) with [123I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane (FP-CIT). The intensity of tremor (i.e., the power of Electromyography [EMG] signals), but not its frequency, significantly increased during the task. In six subjects, tremor appeared selectively during the task. In a second part of the study, we retrospectively reviewed SPECT with FP-CIT data and confirmed the lack of correlation between dopaminergic loss and tremor by comparing DAT binding values of 82 PD subjects with bilateral tremor (n = 27), unilateral tremor (n = 22), and no tremor (n = 33). This study suggests a role of the LC in Parkinson tremor.

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Noradrenergic effects in tardive dyskinesia, akathisia and pseudoparkinsonism via the limbic system and basal ganglia

Cited by 22 publications

References 32 publications

Early Nonresponse Determined by the Clinical Global Impressions Scale Predicts Poorer Outcomes in Youth with Schizophrenia Spectrum Disorders Naturalistically Treated with Second-Generation Antipsychotics

Early Nonresponse Determined by the Clinical Global Impressions Scale Predicts Poorer Outcomes in Youth with Schizophrenia Spectrum Disorders Naturalistically Treated with Second-Generation Antipsychotics

Noradrenaline and Parkinson's Disease

A role for locus coeruleus in Parkinson tremor

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