Nordihydroguiaretic acid attenuates skin tumorigenesis in Swiss albino mice with the condition of topical co-administration of an immunosuppressant

Rahman, Shakilur; Farooque, Abdullah; Anjum, Sameya; Ansari, Rizwan; Adhikari, Jawahar Singh; Dwarakanath, Bilikere S.; Raisuddin, Sheikh

doi:10.1016/j.cbi.2015.03.006

Cited by 3 publications

(1 citation statement)

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“…Isopimpinellin (7), sulforaphane (8) and silibinin (9), antagonists of tumour initiation and promotion, provide nucleotide O6 or O7 fitting points. Hexahydrocolupulone (10), nordihydroguaiaretic acid (11) and folic acid (12) protect against skin changes in the mouse two-step skin carcinogenesis model (Hsu et al 2013;Rahman et al 2015;Koul et al 2018).…”

Section: Tumour Initiators and Modulatorsmentioning

confidence: 99%

Tumour initiation, store-operated calcium entry (SOCE) and apoptosis: cyclic nucleotide dependence

Williams

2020

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Chemical instigators and modulators of tumourigenesis influence cell signal transduction pathways. Cyclic nucleotides and steroid hormones may contribute to the process of carcinogenesis or provide protection via apoptotic mechanisms. Although several pharmacologic classes of compounds influence cyclic nucleotide levels markedly, less is known about the class effects of promoters and blockers of tumourigenesis and apoptosis. This molecular modeling study uses cyclic nucleotide templates to investigate relative molecular similarity within compounds modulating tumourigenesis and apoptosis. Findings, in respect of superimposition and molecular fit of the investigated compounds, are related to their individual effects on cyclic nucleotide pharmacology. Modulators of tumourigenesis and estrogen receptor sub-type ligands relate to cyclic nucleotide structure. Estradiol and GPER ligands provide a similar pattern of fit to adenine nucleotide. Chemically diverse modulators of apoptosis, including K + channel ligands, fit to different components of cyclic nucleotide structure. Compounds modulating Ca 2+ entry and IP3 receptors relate structurally to the nucleotide dioxaphosphinin moiety. Relative molecular similarity within the structures of apoptosis and tumourigenesis modulators identifies a unifying property within chemically disparate compounds. The ubiquitous generation of oxidative stress and ROS in cells by apoptosis modulating compounds may relate to the disruption of cyclic nucleotide regulated homeostasis mechanisms.

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Section: Tumour Initiators and Modulatorsmentioning

confidence: 99%

Tumour initiation, store-operated calcium entry (SOCE) and apoptosis: cyclic nucleotide dependence

Williams

2020

gpb

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Potential inhibition of 12- O -tetradecanoylphorbol-13-acetate-induced inflammation, hyperproliferation, and hyperplasiogenic responses by celecoxib in mouse skin

Rahman,

Haque,

Raisuddin

2024

Cutaneous and Ocular Toxicology

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An insight into impact of nanomaterials toxicity on human health

Qamar,

Gulia,

Athar

et al. 2024

PeerJ

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In recent years, advances in nanotechnology have significantly influenced electronics manufacturing, industrial processes, and medical research. Various industries have seen a surge in the use of nanomaterials. However, several researchers have raised the alarm about the toxicological nature of nanomaterials, which appear to be quite different from their crude forms. This altered nature can be attributed to their unique physicochemical profile. They can adversely affect human health and the environment. Nanomaterials that have been released into the environment tend to accumulate over time and can cause a significant impact on the ecosystem and organisms with adverse health effects. Increased use of nanoparticles has led to increased human exposure in their daily lives, making them more vulnerable to nanoparticle toxicity. Because of their small size, nanomaterials can readily cross biological membranes and enter cells, tissues, and organs. Therefore, the effect of nanomaterials on the human environment is of particular concern. The toxicological effects of nanomaterials and their mechanisms of action are being researched worldwide. Technological advances also support monitoring new nanomaterials marketed for industrial and household purposes. It is a challenging area because of the exceptional physicochemical properties of nanomaterials. This updated review focuses on the diverse toxicological perspective of nanomaterials. We have discussed the use of different types of nanoparticles and their physiochemical properties responsible for toxicity, routes of exposure, bio-distribution, and mechanism of toxicity. The review also includes various in vivo and in vitro methods of assessing the toxicity of nanomaterials. Finally, this review will provide a detailed insight into nano material-induced toxicological response, which can be beneficial in designing safe and effective nanoparticles.

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Nordihydroguiaretic acid attenuates skin tumorigenesis in Swiss albino mice with the condition of topical co-administration of an immunosuppressant

Cited by 3 publications

References 46 publications

Tumour initiation, store-operated calcium entry (SOCE) and apoptosis: cyclic nucleotide dependence

Tumour initiation, store-operated calcium entry (SOCE) and apoptosis: cyclic nucleotide dependence

Potential inhibition of 12- O -tetradecanoylphorbol-13-acetate-induced inflammation, hyperproliferation, and hyperplasiogenic responses by celecoxib in mouse skin

An insight into impact of nanomaterials toxicity on human health

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