Norditerpenoid alkaloids from <i>Delphinium anthriscifolium</i>

Wang, Shuo; Zhou, Xiaolei; Gong, Xiaomei; Fan, Xi-Yuan; Lan, Ming-Shen

doi:10.1080/10286020.2015.1056522

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…D. anthriscifolium var. majus is a traditional Chinese remedy with therapeutic effects on clearing heat, detoxification, healing cough, and treating phlegm (27). In Tibetan folk medicine, the aerial portions of D. caeruleum, known as Daimusa, have been revealed to have therapeutic potential against inflammation, diarrhea, and edema (28).…”

Section: Traditional Applicationmentioning

confidence: 99%

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Chemistry, biological activities and toxic effects of alkaloidal constituents of genus Delphinium - A mini review

Lotfaliani

Ayatollahi

Kobarfard

et al. 2021

J Herbmed Pharmacol

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The genus Delphinium is one of the essential members of the family Ranunculaceae. These species grow wild in North America, Europe, and Asia. They have demonstrated antioxidant, antimicrobial, and cytotoxic activities. Diterpenoid alkaloids are their main constituents and seem to be responsible for medicinal and toxic properties. The primary purpose of this paper is to review the therapeutic benefits of Delphinium species, chemical composition, and its medicinal uses, in addition to the reported toxic effects of these plants influencing different animals and humans.

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Section: Traditional Applicationmentioning

confidence: 99%

“…There are two different alkaloid isolates from the species D.anthriscifolium var. majus, anthriscifolcones A and B, which both have a lycoctonine skeleton from the whole plant of this species (27). Another study on D. anthriscifolium was performed by Shan, et al to evaluate the alkaloid content of the species.…”

Section: Traditional Applicationmentioning

confidence: 99%

Chemistry, biological activities and toxic effects of alkaloidal constituents of genus Delphinium - A mini review

Lotfaliani

Ayatollahi

Kobarfard

et al. 2021

J Herbmed Pharmacol

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“…Delphinium anthriscifolium Hance, belonging to the genus Delphinium of family Ranunculaceae, is a perennial herb growing in the regions of Guangdong, Guangxi, Guizhou, Hunan, and Jiangxi of China [ 1 , 2 ]. It has effects of dispelling wind and dampness, activating collaterals, and relieving pains and is used to treat rheumatism, hemiplegia, indigestion, and cough.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood

Shao

Jin

et al. 2018

Journal of Analytical Methods in Chemistry

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Delsoline, a major alkaloid of Delphinium anthriscifolium Hance, has both a curare-like effect and a ganglion-blocking effect and is used to relieve muscle tension or hyperkinesia. A ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established for the determination of delsoline in mouse blood, and the pharmacokinetics of delsoline after intravenous administration (1 mg/kg) and intragastric administration (9, 6, and 3 mg/kg) were studied. Gelsenicine served as an internal standard, and a UPLC BEH C18 chromatographic column was used. The mobile phase consisted of acetonitrile and 0.1% formic acid; the gradient elution flow rate was 0.4 mL/min. The MRM model was used for the quantitative analysis of delsoline m/z 468.3⟶108.1 and the internal standard m/z 327.1⟶296.1. Mouse blood samples were treated with acetonitrile precipitation to remove proteins. In the concentration range of 0.1–1000 ng/mL, delsoline in mouse blood showed a good linearity (r2 > 0.995), and the lower limit of quantitation was 0.1 ng/mL. The intraday precision relative standard deviation (RSD) was below 14%, and the interday precision RSD was below 15%. The accuracy ranged between 94.3% and 110.1%, the average recovery was above 90.8%, and the matrix effect ranged between 97.0% and 102.5%. The UPLC-MS/MS method was sensitive, rapid, and selective in the study of pharmacokinetics of delsoline. The absolute bioavailability of delsoline was 20.9%.

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The diterpenoid alkaloids

Liu

Qin

et al. 2022

The Alkaloids: Chemistry and Biology

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Norditerpenoid alkaloids from Delphinium anthriscifolium

Cited by 6 publications

References 7 publications

Chemistry, biological activities and toxic effects of alkaloidal constituents of genus Delphinium - A mini review

Chemistry, biological activities and toxic effects of alkaloidal constituents of genus Delphinium - A mini review

Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood

The diterpenoid alkaloids

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