2008
DOI: 10.1080/14756360701810140
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Norditerpenoid alkaloids from the roots ofAconitum heterophyllumWall with antibacterial activity

Abstract: Two new aconitine-type norditerpenoid alkaloids 6-dehydroacetylsepaconitine (1) and 13-hydroxylappaconitine (2), along with three known norditerpenoid alkaloids lycoctonine, delphatine and lappaconitine were isolated from the roots of the Aconitum heterophyllum Wall. These compounds exhibited significant antibacterial activity. The structure of compound 1 and 2 were deduced on the basis of their spectral data.

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Cited by 54 publications
(19 citation statements)
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“…Rapaics [44] Two flavonoids, liquiritin and liquiritigenin, were extracted from the processed Aconiti tuber [45] Two new aconitine-type norditerpenoid alkaloids, 6-dehydroacetylsepaconitine and 13-hydroxylappaconitine, along with three known norditerpenoid alkaloids, were isolated from the roots of the A. heterophyllum Wall. These compounds exhibited significant antibacterial activity [46] Two new diterpenoid alkaloids, heterophyllinine-A (1) and heterophyllinine-B (2), along with two known alkaloids, were isolated from the roots of A. heterophyllum Wall. The structures were deduced on the basis of spectral data [47] Pharmacological/ Biological…”
Section: Role Of Biotechnology In Conservationmentioning
confidence: 99%
“…Rapaics [44] Two flavonoids, liquiritin and liquiritigenin, were extracted from the processed Aconiti tuber [45] Two new aconitine-type norditerpenoid alkaloids, 6-dehydroacetylsepaconitine and 13-hydroxylappaconitine, along with three known norditerpenoid alkaloids, were isolated from the roots of the A. heterophyllum Wall. These compounds exhibited significant antibacterial activity [46] Two new diterpenoid alkaloids, heterophyllinine-A (1) and heterophyllinine-B (2), along with two known alkaloids, were isolated from the roots of A. heterophyllum Wall. The structures were deduced on the basis of spectral data [47] Pharmacological/ Biological…”
Section: Role Of Biotechnology In Conservationmentioning
confidence: 99%
“…Further, ethanol extracts of AH and CS were standardised using aconitine for the former and stigmasterol for the latter as a chemical marker. Aconitine quantified in AH has been reported for its antibacterial, analgesic, antipyretic, local anaesthetic, anti‐inflammatory, antioxidant, hypolipidemic and antinociceptive properties [25,35,36]. Stigmasterol present in CS has been found to have hypocholesterolaemic, antiosteoarthritic, anti‐inflammatory, anti‐atherosclerotic, antivenom, antiamnestic, anticancer and antioxidative effects, and is also used in cardiovascular diseases [37–39].…”
Section: Discussionmentioning
confidence: 99%
“…Demethylenedelcorine, 18-O-methylgigactonine, and lepenine of A. sinomontanum exhibited bactericidal and fungicidal activities (Yuan and Wang, 2012). Two new aconitine-type norditerpenoid alkaloids 6-dehydroacetylsepaconitine and 13-hydroxylappaconitine, along with three known norditerpenoid alkaloids of A. heterophyllum, exhibited significant antibacterial activity (Ahmad et al, 2008). Chasmanine, crassicauline A, karacoline, sachaconitine, talatisamine, and yunaconitine from A. episcopale exhibited feeding deterrent activity against the red flour beetle, Tribolium castaneum .…”
Section: Antimicrobial and Pesticidal Activitiesmentioning
confidence: 99%