Norepinephrine Enhances Aerobic Glycolysis and May Act as a Predictive Factor for Immunotherapy in Gastric Cancer

Wang, Yangyang; Wang, Shuchang; Yang, Qin; Li, Jun; Yu, Fengrong; Zhao, Enyue

doi:10.1155/2021/5580672

Cited by 11 publications

(8 citation statements)

References 35 publications

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“…In contrast to our data, decreasing the MAO-B level was reported in BC and many other cancers [19]. Nevertheless, the MAO-B expression diminished in gastrointestinal [31] and oral squamous cell carcinoma [32]. In this regard, evidence from human and animal studies indicated that the MAO expression has been regulated by estrogen.…”

Section: Resultscontrasting

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Breast cancer (BC) is the most epidemic malignancy of women worldwide that leads to cause of morbidity and mortality. Tamoxifen (TAM) is the common therapy used in the BC treatment. Monoamine oxidases are enzymes linked to the progression of many types of carcinomas through its consideration on the production of reactive oxygen species. This study aimed to clarify the correlations between MAO isoforms (MAOs), atherogenic index, TAM, and their roles in the BC progression. 60 newly diagnosed and 60 TAM treated women with BC, as well as 50 healthy volunteers were included in this study. Parameters including MAOs activities, lipid profile, malondialdehyde, and total protein were determined before and after treatment with TAM. The activities of total MAO, MAO-A, MAO-B, and semi-carbazide-sensitive amine oxidase (SSAO) were significantly (P<0.0001) decreased in newly diagnosed and TAM-treated women compared with healthy individual. However, the activities of all tested enzymes were elevated significantly (P<0.0001) in TAMtreated women compared with the newly diagnosed women. The strong positive correlations were found among MAOs in response to TAM treatment. Receiver operating characteristic showed a higher sensitivity and specificity for MAOs in discrimination between newly diagnosed and TAM-treated women. Atherogenic index was significantly increased (P<0.0001) in newly diagnosed and in TAM-treated women compared with control. The findings of this study indicated that BC patients are more vulnerable to cardiovascular diseases, independent of TAM and MAOs effect. Based on the forgoing, MAOs can be used as a diagnostic marker for BC progression.

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Section: Resultscontrasting

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…MAO-A and MAO-B appeared to be expressed in low levels. The high levels of norepinephrine and low MAO-B expression could be a good target for immune therapy [ 69 ].…”

Section: Mao-b’s Role In Cancermentioning

confidence: 99%

Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development

et al. 2021

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Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.

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“…The biological functions of catecholamines are mediated by adrenergic receptor (AR) families, with β2-AR being the main type expressed in GC [ 55 ]. The levels of noradrenaline and the expression of β2-AR were aberrantly elevated in GC tissues compared with adjacent normal gastric mucosa [ 55 , 56 ]. Catecholamines were shown to enhance the ability of primary GC cells to migrate to the liver and lung to form metastases, while propranolol can abolish the formation of metastatic lesions [ 55 ].…”

Section: Mechanisms Underlying the Increased Recurrence Rate Resultin...mentioning

confidence: 99%

The Impact of Perioperative Events on Cancer Recurrence and Metastasis in Patients after Radical Gastrectomy: A Review

Zhi

Kuang

2022

Cancers

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Radical gastrectomy is a mainstay therapy for patients with locally resectable gastric cancer (GC). GC patients who are candidates for radical gastrectomy will experience at least part of the following perioperative events: surgery, anesthesia, pain, intraoperative blood loss, allogeneic blood transfusion, postoperative complications, and their related anxiety, depression and stress response. Considerable clinical studies have shown that these perioperative events can promote recurrence and decrease the long-term survival of GC patients. The mechanisms include activation of neural signaling and the inflammatory response, suppression of antimetastatic immunity, increased release of cancer cells into circulation, and delayed adjuvant therapy, which are involved in every step of the invasion-metastasis cascade. Having appreciated these perioperative events and their influence on the risk of GC recurrence, we can now use this knowledge to find strategies that might substantially prevent the deleterious recurrence-promoting effects of perioperative events, potentially increasing cancer-free survival in GC patients.

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Norepinephrine Enhances Aerobic Glycolysis and May Act as a Predictive Factor for Immunotherapy in Gastric Cancer

Cited by 11 publications

References 35 publications

Untitled

Untitled

Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development

The Impact of Perioperative Events on Cancer Recurrence and Metastasis in Patients after Radical Gastrectomy: A Review

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