Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study ISCRTN70707830

Martı́nez-Lavı́n, Manuel; Vidal, Marcela; Barbosa, Rosa-Elda; Pineda, Carlos; Casanova, Jose-Miguel; Nava, Arnulfo

doi:10.1186/1471-2474-3-2

Cited by 67 publications

(47 citation statements)

References 16 publications

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“…In apparent contrast to the above, some authors have demonstrated basal LC-NE hyperfunction [111]and increased central CRH release [112]in FM patients. Such discrepant findings might be due to associated anxiety, depression, sleep disturbances, level of physical activity/deconditioning, diet factors such as caffeine consumption, variation of LC-NE/HPA axis functioning over time, and heterogeneity of FM subgroups [48, 113, 114].…”

Section: Possible Pathophysiological Mechanismsmentioning

confidence: 95%

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Fibromyalgia: A Stress Disorder?

Houdenhove

Egle

2004

Psychother Psychosom

201

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Fibromyalgia (FM) is a controversial syndrome, characterised by persistent widespread pain, abnormal pain sensitivity and additional symptoms such as fatigue and sleep disturbance. The syndrome largely overlaps with other functional somatic disorders, particularly chronic fatigue syndrome (CFS). Although the exact aetiology and pathogenesis of FM are still unknown, it has been suggested that stress may play a key role in the syndrome. This article first reviews the function of the stress response system, placing special emphasis on the relationships between adverse life experiences, stress regulation and pain-processing mechanisms, and summarising the evidence for a possible aetiopathogenetic role of stress in FM. Finally, an integrative biopsychosocial model that conceptualises FM as a stress disorder is proposed, and the clinical and research implications of the model are discussed.

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Section: Possible Pathophysiological Mechanismsmentioning

confidence: 95%

“…Sympathetic hyperfunction may be related to the clinical observation of a whole range of neurovegetative symptoms in FM and experimental findings of NE-evoked pain in these patients [111]. …”

Section: Possible Pathophysiological Mechanismsmentioning

confidence: 99%

Fibromyalgia: A Stress Disorder?

Houdenhove

Egle

2004

Psychother Psychosom

201

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“…Some of these studies showed elevated function in the sympathetic nervous system. [4][5][6][7] Martinez-Lavin et al [19] suggested that fibromyalgia patients have norepinephrine-evoked pain which may be resolved by sympatholytic maneuvers. They also proposed that sympathetic hyperactivity may explain some of the manifestations of FMS including sleep disorders, irritable bowel syndrome, sicca symptoms and anxiety.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Sympathetic Skin Response and F Wave in Fibromyalgia Syndrome Patients

et al. 2011

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“…However, when an acute stress is imposed on the system, notably under conditions in which the monoamine system is challenged, the COMT deficiency can be uncovered in a pattern consistent with gene-environment interaction. This might well be the case in fibromyalgia (Martinez-Lavin & Hermosillo, 2000;Martinez-Lavin et al, 2002).The COMT Val158Met polymorphism has been linked to a decrease in pain tolerance in healthy volunteers (Zubieta et al, 2003). Studies on healthy volunteers have also shown greater brain activation in the limbic region of Met/Met carriers in reaction to an emotionally challenging situation such as the presentation of unpleasant stimuli (Zubieta et al, 2003;Smolka et al, 2005Smolka et al, , 2007Drabant et al, 2006).…”

mentioning

confidence: 99%

Psychological distress in fibromyalgia patients: A role for catechol-O-methyl-transferase Val158met polymorphism.

Desmeules¹,

Piguet²,

Besson³

et al. 2012

Health Psychology

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Objective: Fibromyalgia (FM) has been related to biochemical alterations, central pain sensitization and psychological distress. Among genetic and environmental hypotheses, a role was suggested for catechol-O-methyl-transferase (COMT), a modulator in the metabolism of monoaminergic neurotransmitters. Method: This study compared the COMT Val158Met enzyme polymorphism (rs4680) of 198 FM patients to 99 pain-free controls. Psychological and functional aspects were assessed through investigating anxiety, depression, catastrophizing, perceived health, and functional status. Results: The distribution of the COMT Val158Met polymorphism was similar in FM and controls. Out of 198 patients, 137 were able to stop medication before evaluation. In these patients, the COMT Val158Met genotype was associated with specific psychological profiles. The Met/Met subgroup scored systematically worse on all psychological and functional variables. All variables displayed a "genotype-trend effect" with the Met/Met and Val/Val subgroups at the two ends of the scores. Genotypes distribution in the 61 patients unable to stop medication was significantly different from that of patients able to stop medication and controls (p ϭ .002 and p ϭ .018, respectively) with an increase in the proportion of the Met/Met genotype associated to the lowest COMT activity. These results suggest a possible role of COMT Val158Met polymorphism in the psychological distress observed in FM. Conclusions: The association of COMT genotype with psychological distress may be of importance as identifying subgroups is a challenge in the diagnosis and treatment of fibromyalgia patients. This association may contribute to open new perspectives into the understanding of the pathophysiology of fibromyalgia and stress-related genes.

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Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study ISCRTN70707830

Cited by 67 publications

References 16 publications

Fibromyalgia: A Stress Disorder?

Fibromyalgia: A Stress Disorder?

Evaluation of Sympathetic Skin Response and F Wave in Fibromyalgia Syndrome Patients

Psychological distress in fibromyalgia patients: A role for catechol-O-methyl-transferase Val158met polymorphism.

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