Norfloxacin Prophylaxis for Endoscopic Urological Surgery

Cutajar, C. L.

doi:10.1111/j.1464-410x.1992.tb15571.x

Cited by 11 publications

(11 citation statements)

References 13 publications

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“…The recommended antimicrobials to prevent UTIs after TUR-Bt are injective CEPs and oral fluoroquinolones (FQLs). [16][17][18][19][20]22,28,[30][31][32][33][34][35] Attention to fluoroquinolone-resistant Escherichia coli should be paid , however, because its prevalence has been reported. 36 In Western countries, the dosages of antimicrobials are higher than that in Japan.…”

Section: (2) Perioperative Infections In Tur-bt 13-20mentioning

confidence: 99%

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Japanese guidelines for prevention of perioperative infections in urological field

et al. 2007

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For urologists, it is very important to master surgical indications and surgical techniques. On the other hand , the knowledge of the prevention of perioperative infections and the improvement of surgical techniques should always be considered. Although the prevention of perioperative infections in each surgical field is a very important issue, the evidence and the number of guidelines are limited. Among them, the preparation of guidelines has progressed , especially in gastrointestinal surgery. The Center for Disease Control and Prevention (CDC) proposed guidelines for the prevention of surgical site infections, which have been used worldwide. In urology, the original guidelines were different from those of general surgery, due to many endourological procedures and urine exposure in the surgical field. The Japanese Society of UTI Cooperative Study Group has thus framed these guidelines supported by The Japanese Urological Association. The guidelines consist of the following nine techniques: open surgeries, laparoscopic surgeries, transurethral resection of bladder tumor, ureterorenoscope and transurethral lithotripsy, transurethral resection of the prostate, prostate biopsy, cystourethroscope, pediatric surgeries in the urological field , and extracorporeal shock wave lithotripsy and febrile neutropenia. These are the first guidelines for the prevention of perioperative infections in the urological field in Japan. Although most of these guidelines were made using reliable evidence, there are parts without enough evidence. Therefore, if new reliable data is reported , it will be necessary for these guidelines to be revised in the future. Key words:Open surgery, Laparoscopic surgery, TUR, Prostate biopsy, Cystourethroscope, ESWL. I. General remarksUrological practice mainly consists of surgical procedures, since the field of urology is a division of surgery. Therefore, it is very important to master surgical indications and surgical techniques. On the other hand , the knowledge of the prevention of perioperative infections and the improvement of surgical techniques should always be considered. Although the prevention of perioperative infections in each surgical field is a very important issue, these evidences are limited and the number of guidelines is limited. Among them, the preparation of guidelines has progressed , especially in gastrointestinal surgery. The Center for Disease Control and Prevention (CDC) proposed guidelines for the prevention of surgical site infections), 1 which have been used worldwide. In urology, the original guidelines were different from those of general surgery, due to many endourological procedures and urine exposure in the surgical field. We have thus framed these guidelines supported by The Japanese Urological Association. I-I Definition and classification of perioperative infectionsA perioperative infection is defined as an infection that occurs within one month after an operation. These infections are divided into two groups: surgical site infections (SSIs) and remote i...

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Section: (2) Perioperative Infections In Tur-bt 13-20mentioning

confidence: 99%

“…On the other hand , 3-day AMP has been recommended in some studies. 16,26 No past studies on the comparison between 1-day and 3-day administration are available. Furthermore, the catheter-indwelling time was not unified in all of the past studies.…”

Section: (2) Perioperative Infections In Tur-bt 13-20mentioning

confidence: 99%

Japanese guidelines for prevention of perioperative infections in urological field

et al. 2007

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“…The incidence (3.4%) was equivalent to that (2.3%) in patients with single dose of fluoroquinolone, which some previous studies recommended as AMP for TURBT. [1][2][3][4][5][6] Moreover, these symptomatic UTIs were easily treated by deferred use of antibiotics. Three of the four patients having UTIs with no AMP received only oral antibiotics, and the remaining one was treated by parenteral treatment for several days.…”

Section: Discussionmentioning

confidence: 99%

“…However, there were a few studies to evaluate the efficacy of AMP on infectious complications after TURBT with controversial results. Some studies have recommended the use of AMP for TURBT [1][2][3][4][5][6][7][8][9] because of the relatively high incidences of postoperative urinary tract infections (UTIs) including bacteriuria ranging from 10% to 40%. 10,11 Other studies reported that AMP for TURBT is not necessary.…”

Section: Introductionmentioning

confidence: 99%

Discarding antimicrobial prophylaxis for transurethral resection of bladder tumor: A feasibility study

et al. 2008

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Objectives:To evaluate the feasibility of discarding antimicrobial prophylaxis (AMP) for transurethral resection of bladder tumor (TURBT). Methods: One-hundred and sixty-two patients undergoing TURBT, with no risk factors for infectious complications were included in this prospective study between April 2006 and April 2008. Forty-four patients received single oral dose of 200 mg levofloxacin for AMP (LVFX group), and the remaining 118 received no AMP (no AMP group). Rates of postoperative infectious complications were compared between the two groups. Results: There was no significant difference between the two groups in terms of baseline characteristics, including age, sex, history of TURBT, number of tumors, duration of operation and days of catheterization. Symptomatic urinary tract infections (UTIs) occurred in four patients (3.4%) in the no AMP group and one patient (2.3%) in the LVFX group (P = 0.61). All patients having UTIs were men, and were successfully treated by immediate administration of antibiotics. No patients developed extra-urinary tract infections. Conclusions: Based on our findings, AMP for TURBT in patients with no risk factors for infectious complications is not necessary. The use of antibiotics might be deferred until postoperative infections develop.

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“… NRF is a widely applied antibiotic for the treatment of respiratory and urinary tract infections, as well as skin infections . In addition, NRF is a safe and effective prophylactic antibiotic used in all forms of urological endoscopic surgery and for minimizing the rate of catheter‐associated bacteriuria and pyuria that can occur after reconstructive gynaecologic surgery …”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of piroxicam and norfloxacin in biological fluids by high‐performance liquid chromatography with fluorescence detection at zero‐order emission mode

et al. 2019

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A new highly sensitive high-performance liquid chromatographic method with fluorescence detection (HPLC-FLD) in zero-order emission mode was developed for the first time for the simultaneous determination of piroxicam (PRX) and norfloxacin (NRF) in biological fluids. The fluorescence detector wavelengths were set at 278 nm for excitation and zero-order mode for emission. The zero-order emission mode produced greater sensitivity for the measurement of both drugs than a fixed emission wavelength (446 nm). The new developed method was validated according to International Conference of Harmonization (ICH) guidelines. Linearity was found to be over concentration ranges 0.001-20 μg/ml and 0.00003-0.035 μg/ml for PRX and NRF, respectively. The limits of detection were 4.87 × 10 −4 and 1.32 × 10 −5 μg/ml for PRX and NRF, and the limits of quantitation were 1.47 × 10 −3 and 4.01 × 10 −5 μg/ml, respectively. The current fluorescence method was found to be more sensitive than most commonly used analytical methods and was successfully applied for simultaneous determination of PRX and NRF in biological fluids (serum and urine) with recoveries ranging from 91.67% to 100.36% for PRX and from 96.00% to 101.43% for NRF.

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Norfloxacin Prophylaxis for Endoscopic Urological Surgery

Cited by 11 publications

References 13 publications

Japanese guidelines for prevention of perioperative infections in urological field

Japanese guidelines for prevention of perioperative infections in urological field

Discarding antimicrobial prophylaxis for transurethral resection of bladder tumor: A feasibility study

Simultaneous determination of piroxicam and norfloxacin in biological fluids by high‐performance liquid chromatography with fluorescence detection at zero‐order emission mode

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