Norfloxacin versus trimethoprim-sulfamethoxazole in the therapy of uncomplicated, community-acquired urinary tract infections

Goldstein, E J; Alpert, Marc; Ginsberg, B P

doi:10.1128/aac.27.3.422

Cited by 29 publications

(20 citation statements)

References 13 publications

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“…After (2,4,9,14). Of all the quinolones evaluated against MRSA in this study, A-56619, A-56620, ciprofloxacin, and ofloxacin inhibited growth at lower concentrations that did the other three quinolones; however, all agents were effectively bactericidal.…”

mentioning

confidence: 97%

In vitro comparison of A-56619, A-56620, amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin against methicillin-resistant Staphylococcus aureus

Smith¹

1986

Antimicrob Agents Chemother

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Seven quinolone antibiotics were tested against 115 isolates of methicillin-resistant Staphylococcus aureus. The MICs for 90% of the strains tested were 0.5 ,ug/ml for A-56619, A-56620, ciprofloxacin, and ofloxacin; 2.0 ,ug/ml for amifloxacin and enoxacin; and 4.0 ,ug/ml for norfloxacin. Killing kinetic studies showed a similar killing rate for all seven antibiotics.Methicillin-resistant Staphylococcus aureus (MRSA) has become a major pathogen in patients who are intravenous drug abusers and in patients who have nosocomially acquired infections, and it has also become a major colonizing organism in health care workers (7,10,16

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confidence: 97%

In vitro comparison of A-56619, A-56620, amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin against methicillin-resistant Staphylococcus aureus

Smith¹

1986

Antimicrob Agents Chemother

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“…Norfloxacin, when given with one exception (14) in doses of 400 mg orally twice daily, demonstratqd significantly higher (35,36) or equivalent rates of cure when compared in eight randomized, nonblinded studies to orally administered trimethoprim-sulfamethoxazole (14,16,18,19,36,40), amoxicillin (28), or nalidixic acid (35) ( Table 2). When specified (eight studies), most studies included only patients with uncomplicated infections (absence of catheters, structural defects in the urinary tract, or abnormal renal function) (11,14,16,19,25,(34)(35)(36). In the two studies that included complicated infections (catheterized patients, some elderly with mild degrees of azotemia), 84 to 95% of the patients were reported cured (27,28).…”

Section: Introductionmentioning

confidence: 99%

The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans

Hooper¹,

Wolfson²

1985

Antimicrob Agents Chemother

394

204

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“…Among those trials that determined bacterial susceptibilities after norfloxacin therapy [10][11][12][13][15][16][17], only one therapeutic failure was due to superinfection with a resistant group B streptococcal strain [16].…”

Section: Randomized Trials With Fluoroquinolones For the Treatment Ofmentioning

confidence: 99%

“…t Duration of treatment was 10 days in seven of 12 trials [10-14, 56, 58], 7-10 days in two trials [15,16], 7 days in one trial [57], 3-10 days in one trial [59], and a single dose in one trial [17].…”

Section: S155mentioning

confidence: 99%

Comparative Studies of Fluoroquinolones in the Treatment of Urinary Tract Infections

Malinverni¹,

Glauser²

1988

Clinical Infectious Diseases

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The resultsof comparative trials of fluoroquinolones for the treatment of uncomplicated and complicated urinary tract infections (UTI) were reviewed. Severalrandomized, comparative trials showedthat in uncomplicated UTI norfloxacin, ciprofloxacin, and ofloxacin wereat least as effectiveas trimethoprim-sulfamethoxazole (TMP-SMZ) and amoxicillinand usually more effectivethan nalidixicacid, pipemidic acid, and nitrofurantoin. Comparativetrials of single-dose regimens have, however, been limited. A few randomized, comparative trials have shown that in complicated UTI norfloxacin, ciprofloxacin, and ofloxacin wereat least as effectiveas amoxicillinand TMP-SMZand usually more effective than pipemidic acid. Moreover, preliminary results indicate that fluoroquinolones might be effective for the oral treatment of complicated UTI that are difficult to treat, especially those due to Pseudomonas aeruginosa. Comparative trials are needed to establish the value of fluoroquinolones for chronic bacterial prostatitis. There are no conclusivedata on fluoroquinolone treatment of UTI in patients with renal failure. Emergence of resistantpathogens during therapywith fluoroquinolones has beeninfrequentbut might be more frequent in complicated UTI caused by P. aeruginosa.Although highly effective and well-established antibiotic regimens are available for the treatment of urinary tract infection (UTI), there is a need for new antimicrobial agents, especially for the treatment of outpatients with UTI that are difficult to treat and for which most of the drugs available for oral treatment are ineffective.The fluoroquinolones have several properties that suggest their potential clinical utility for the treatment of UTI, including high activity in vitro against virtually all urinary tract pathogens and good absorption after oral administration that results in prolonged high levels of drug in urine [1].The methodologic problems associated with open and comparative trials evaluating the efficacy of new antibiotics for the treatment of UTI have recently been reviewed [2]. For this review of the efficacy of fluoroquinolones for the treatment of UTI, we have emphasized those studies that have both sufficient data for a clear classification of UTI and data on We thank Mrs. Kathrin Zsirmik and Mrs. Alexandra Bloch for typing the manuscript.Please address requests for reprints to R. Malinverni, Medizinische Universitatsklinik, Inselspital, CH-3010 Bern, Switzerland. follow-up urine cultures 4-6 weeks after the end of treatment (unless otherwise mentioned). In this evaluation, bacteriologic cure (sterile urine) was considered as the end point of antibiotic treatment since the definitions of clinical response, when stated, varied from one study to another and symptoms may disappear in the absence of bacteriologic cure. In table 1, which outlines the efficacy of fluoroquinolone treatment of UTI by infecting organism, only data from studies (noncomparative and comparative) that provided sufficient information to permit a clear classification of UTI...

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Norfloxacin versus trimethoprim-sulfamethoxazole in the therapy of uncomplicated, community-acquired urinary tract infections

Cited by 29 publications

References 13 publications

In vitro comparison of A-56619, A-56620, amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin against methicillin-resistant Staphylococcus aureus

In vitro comparison of A-56619, A-56620, amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin against methicillin-resistant Staphylococcus aureus

The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans

Comparative Studies of Fluoroquinolones in the Treatment of Urinary Tract Infections

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