Norisoboldine, an alkaloid fromRadix linderae, inhibits NFAT activation and attenuates 2,4-dinitrofluorobenzene-induced dermatitis in mice

Abstract

This study demonstrates that NOR inhibits NFAT activation in T-cells and alleviates AD-like inflammatory reaction in a DNCB-induced dermatitis model, highlighting NOR as a potential therapeutic agent for AD.

Mechanism of Wuyao–Ginseng Medicine Pair in the Prevention and Treatment of Diarrhea-Type Irritable Bowel Syndrome Based on Gene Expression Omnibus Chip Data

“…As an important traditional Chinese medicine for the treatment of digestive diseases, wuyao is clinically used for functional gastrointestinal diseases such as chest tightness, abdominal distension, vomiting and hiccups, abdominal distensions, pain from cold and qi stagnation, and gastrointestinal neurosis such as qi stagnation [ 12 ]. The chemical components of aconitum officinalis mainly include volatile oils, isoquinoline alkaloids, quiterpene furans, and flavonoids [ 13 , 14 ], which have anti-inflammatory, analgesic, anti-rheumatic, anti-oxidation, anti-bacterial, anti-fatigue, cardiovascular protection, regulation of gastrointestinal movements, and other pharmacological effects [ 15 , 16 , 17 ]. Ginseng has functions of invigorating qi, reinvigorating the pulse, reinforcing removals, invigorating the spleen, and invigorating lungs.…”

A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

“…Besides anti-arthritis activity, NOR has other activities. For example, NOR could reduce 2,4-dinitrofluorobenzene-induced dermatitis in mice by inhibiting nuclear factor of activated T-cells (NFAT) ( 92 ). It regulates the polarization of macrophages through the M2 pyruvate kinase (PKM2)/hypoxia-inducible factor (HIF-1α)/peroxisome proliferator activated receptor-γ co-activator 1-α (PGC-1α) pathway, thus alleviating sepsis-induced acute lung injury ( 93 ).…”

“…Sesquiterpene dimers are a characteristic class of constituents with C 30 cores in L. aggregata, which are plausibly biosynthesized via the coupling of two identical or different sesquiterpenoid molecules (32). Forty-three dimers have been reported, among which lindenane-type sesquiterpenoid dimers are the most representative structures, such as linderaggrenolides A-N (88)(89)(90)(91)(92)(93)(94)(95)(96)(97)(98)(99)(100)(101) and linderanoids H-O (109)(110)(111)(112)(113)(114)(115)(116), where linderaggrenolides A-N have an oxygen bridge (32,33). The remaining dimeric sesquiterpene components, such as linderanoids A-G (102-108), include 3 sesquiterpenoid dimers comprising a lindenane and a noreudesmane unit (102-104); 2 dimers consisting of a lindenane and an eudesmane unit (105)(106), and 2 dimers containing a lindenane and an elemanolide unit (107-108) (33).…”

Norisoboldine, a Natural Isoquinoline Alkaloid, Inhibits Diaphyseal Fracture Healing in Mice by Alleviating Cartilage Formation

“…Many kinds of isoquinoline alkaloids isolated from plants have various pharmacological activities, such as anti-inflammatory, antiviral, cytotoxic, and ROS scavenger properties [6]. Using modern technologies, NOR has been proven to attenuate sepsis-induced acute lung injury [7], suppress anti-inflammatory activity in atopic dermatitis by inhibiting the nuclear factor of activated T-cells (NFAT) [8], suppress endothelial cell migration [9], etc. In the musculoskeletal system, NOR works as an agonist of the aryl hydrocarbon receptor to alleviate osteoclast differentiation and inflammatory bone erosion in rats [5], possibly by activating mitogen-activated protein kinases (MAPKs)-nuclear factor kappa-light-chain-enhancer of activated B-cells (NFκB) pathways [10].…”