Norm index-based QSTR model to predict the eco-toxicity of ionic liquids towards Leukemia rat cell line

Yan, Fangyou; Lan, Tian; Yan, Xue; Jia, Qi; Wang, Qiang

doi:10.1016/j.chemosphere.2019.06.064

Cited by 25 publications

(6 citation statements)

References 42 publications

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“…5 Some studies indicate that the toxicity can be attributed to both the anion and cation present in the IL. 6,7 A good strategy to reduce the amount of an IL required to carry out a process or a reaction is to mix ILs with other solvents, such as an organic solvent or even water. 8,9 For example, Harper et al studied the effect of the variation of the mole fraction of an IL (χIL) in a molecular solvent on the outcome of organic reactions.…”

Section: ■ Introductionmentioning

confidence: 99%

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Choline [Amino Acid] Ionic Liquid/Water Mixtures: A Triple Effect for the Degradation of an Organophosphorus Pesticide

et al. 2020

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A series of ionic liquids (ILs) composed by choline (Ch) as a cation and different amino acids (AA) as anions and their respective aqueous mixtures were prepared using different [Ch][AA] contents in a range of 0.4–46 mol % IL. These solvents were used for the first time to achieve an eco-friendlier Paraoxon degradation. The results show that [Ch][AA]/water mixtures are an effective reaction medium to degrade Paraoxon, even when the IL content in the mixture is low (0.4 mol % IL) and without the need of an extra nucleophile. Both the kinetics and the degradation pathways of pesticides depend on the nature of the AA on [Ch][AA] and the amount of an IL present in the mixture. We have demonstrated that in those mixtures with a low amount of [Ch][AA], the hydrolysis reaction is the main pathway for Paraoxon degradation, showing a catalytic effect of the IL. However, as the percentage of [Ch][AA] increases in the mixture, the nucleophilic attack of [Ch][AA] is evident. Finally, the aim of this study was to provide evidence of a promising and biocompatible methodology to degrade a toxic compound (Paraoxon) using a minimal quantity of an IL designed totally from natural resources.

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Section: ■ Introductionmentioning

confidence: 99%

“…There are many reports indicating that these ILs are neither sustainable nor biodegradable, and in many cases, they exhibit relatively high toxicity . Some studies indicate that the toxicity can be attributed to both the anion and cation present in the IL. , …”

Section: Introductionmentioning

confidence: 99%

Choline [Amino Acid] Ionic Liquid/Water Mixtures: A Triple Effect for the Degradation of an Organophosphorus Pesticide

et al. 2020

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“…However, this type of model is more time-consuming. A new norm index-based QSTR was developed by Yan et al [ 175 ] to predict the ecotoxicity of ILs on Leukemia rat cell lines (IPC-81). In this work, a new set of descriptors to characterize the interaction between anions and cations and some new atomic distribution matrices were constructed to calculate norm descriptions of ILs.…”

Section: Effect Of Ionic Liquids On Animalsmentioning

confidence: 99%

Ionic Liquids—A Review of Their Toxicity to Living Organisms

Gonçalves

Paredes

Cristino

et al. 2021

IJMS

128

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Ionic liquids (ILs) were initially hailed as a green alternative to traditional solvents because of their almost non-existent vapor pressure as ecological replacement of most common volatile solvents in industrial processes for their damaging effects on the environment. It is common knowledge that they are not as green as desired, and more thought must be put into the biological consequences of their industrial use. Still, compared to the amount of research studying their physicochemical properties and potential applications in different areas, there is a scarcity of scientific papers regarding how these substances interact with different organisms. The intent of this review was to compile the information published in this area since 2015 to allow the reader to better understand how, for example, bacteria, plants, fish, etc., react to the presence of this family of liquids. In general, lipophilicity is one of the main drivers of toxicity and thus the type of cation. The anion tends to play a minor (but not negligible) role, but more research is needed since, owing to the very nature of ILs, except for the most common ones (imidazolium and ammonium-based), many of them are subject to only one or two articles.

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“…Ionic liquids (ILs), a kind of molten salt, possess many unique properties, such as high ionic conductivity, chemical and thermal stability, a wide operating window, and low vapor pressure. , Because of these interesting features, IL-based conductive elastomers (ICEs) consisting of soft elastomeric polymer networks filled with ILs have recently been proposed to construct flexible electronic sensors. − The fabricated sensors have achieved high sensitivity to a broad range of strains and pressures. − However, because of the plasticizer effect of ILs, most existing ICEs exhibit low mechanical properties and toughness, and they are prone to damage and fatigue at small strains during the repeated deformation processes. , Moreover, the as-reported IL-based elastomers suffer from the issues of IL leakage during the practical applications, which thus would cause gradual deterioration in the conductivity of the electronic devices and even potentially affect human health. − Furthermore, many reported ionogels are unstable under ambient environments because highly hydrophilic ILs can absorb moisture from the air to change their weight, which causes an alternation of various properties including stretchability and conductivity . Thus, it still is a challenging task to develop high-performance IL-based conductors with good mechanical properties and high stability.…”

Section: Introductionmentioning

confidence: 99%

Facile Fabrication of Highly Stretchable, Stable, and Self-Healing Ion-Conductive Sensors for Monitoring Human Motions

Zheng

Wang

et al. 2022

Chem. Mater.

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Ionic liquid (IL)-based conductive elastomers have recently emerged as promising stretchable electrodes for applications in flexible electronic devices because of the interesting features of ILs. However, conventional IL-based elastomers suffer from low mechanical properties, instability in the ambient environment, and lack of self-healability. Herein, highly stretchable, stable, and self-healable IL-based conductive elastomers PnBA/SiO2/PVI (Cu2+, [EMIM]+[BF4]−) were designed and facilely fabricated by one-pot Pickering emulsion polymerization. The Pickering emulsion is composed of the continuous phase of n-butyl acrylate, the dispersed phase containing vinylimidazole, copper acetate and IL ([EMIM]+[BF4]−), and the surfactant vinyl-SiO2. The fabricated materials feature an elastic matrix with microionogel particles embedded in it. The system is chemically and physically cross-linked via vinyl-SiO2 and Cu2+-imidazole coordination interaction, respectively. Such a rational design endows the resulting elastomers with a wide range of properties, including good conductivity, high stretchability, excellent mechanical properties, and self-healability. Besides, owing to this unique structure, they display high stability and their weight and electrical aspects remain almost unchanged in open air and a wide temperature range (30, 50, and 100 °C). Utilizing as flexible sensors, the as-prepared elastomers are able to accurately monitor real-time human motions via converting external stimuli into stable and repeatable signal variations during deformations.

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Norm index-based QSTR model to predict the eco-toxicity of ionic liquids towards Leukemia rat cell line

Cited by 25 publications

References 42 publications

Choline [Amino Acid] Ionic Liquid/Water Mixtures: A Triple Effect for the Degradation of an Organophosphorus Pesticide

Choline [Amino Acid] Ionic Liquid/Water Mixtures: A Triple Effect for the Degradation of an Organophosphorus Pesticide

Ionic Liquids—A Review of Their Toxicity to Living Organisms

Facile Fabrication of Highly Stretchable, Stable, and Self-Healing Ion-Conductive Sensors for Monitoring Human Motions

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