Normal adiponectin levels despite abnormal glucose tolerance (or diabetes) and inflammation in adult patients with cystic fibrosis

Adiponectin and inflammation: Consensus and controversy

“…21 A second study in patients with CF demonstrated absence of alterations in systemic adiponectin levels despite the presence of insulin resistance, glucose intolerance, and subclinical chronic inflammation. 22 Finally, 2 groups evaluated the effect of LPS administration in healthy volunteers and reported that, contrary to expectations, adiponectin levels were not altered, despite the anticipated induction of proinflammatory cytokines and acute-phase response. 23,24 However, lack of modulation of adiponectin levels in this setting may simply reflect the acute nature of the inflammatory response after a single administration of LPS.…”

Adiponectin, Leptin, Resistin Levels In Cystic Fibrosis Adolescents

“…Other studies demonstrated higher adiponectin levels in well nourished adult CF patients than in healthy controls [7; 8; 9] and normal adiponectin levels in CF with diabetes or impaired glucose tolerance and/or positive inflammatory markers [9]. Adiponectin levels were mildly higher in our adolescents than in controls, linked to the low malnutrition state typically present in CF.…”

“…In our patients resistin levels were more elevated than in controls and showed a significant direct correlation with CRP. Nevertheless resistin increase may be the effect of chronic inflammatory pattern typical of CF [9]. Similarly in patients with chronic kidney disease [14] and in critically ill patients serum resistin is correlated to inflammatory markers as CRP [15].…”

“…Adiponectin is higher in adult CF patients than in healthy controls [7]; furthermore adiponectin is paradoxically more elevated in CF patients in adequate nutritional conditions and it is decreased in CF patients with malnutrition [8], but no data are reported in CF children. However, in a recent study CF patients showed normal levels of adiponectin despite abnormal glucose tolerance or diabetes and/or subclinical chronic inflammation [9].…”

The 1-h oral glucose tolerance test glucose and insulin values are associated with markers of clinical deterioration in cystic fibrosis

“…The inclusion/exclusion criteria were previously described in detail [14]. In brief, all subjects taking medications or having health conditions other than CF that could significantly interfere with glucose metabolism were excluded from analysis.…”