Normal Aging Changes of the Scattering Light Intensity in Human Lens Measuring with Scheimpflug Photography

Shyn, Kyung Hwan; Lee, Do Hyung; Hong, Nae Sun; Ro, Se Hyun

doi:10.1159/000425644

Cited by 2 publications

(5 citation statements)

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“…The increase in light scattering intensity of normal transparent lenses with aging has been reported by several authors [3][4][5][6][7][8][9]. Fujisawa and Sasaki [7] measured the peak height of light scattering intensities along the theoretical optical axis of thirteen layers in the transparent lenses of Japanese subjects using a Nidek EAS-1000 instrument.…”

Section: Discussionmentioning

confidence: 81%

“…We selected these six layers because the previous report of Fujisawa and Sasaki [7] showed a strong correlation between the age and peak height in these layers, all located in the anterior to the central part of the lens. Moreover, the decrease in light scattering in the posterior cortex and capsule with aging was explained as an artifact of the method [3][4][5][6][7]9].…”

Section: Discussionmentioning

confidence: 99%

“…Shibata et al [1,2] measured the thickness of transparent lenses in Japanese and German subjects and found that the thickness of a transparent lens increased 0.02 mm per year in both groups. It was also reported that the light scattering intensities of single lens layers increased with aging [3][4][5][6][7][8][9]. From these changes, we proposed a concept for 'lens age' as an indicator of lens transparency in an individual lens [8].…”

Section: Introductionmentioning

confidence: 98%

“…Several studies evaluated the changes with aging of lens thickness and light scattering intensity using Scheimpflug photography [1][2][3][4][5][6][7][8][9] and the reliability of this method has been widely accepted. Shibata et al [1,2] measured the thickness of transparent lenses in Japanese and German subjects and found that the thickness of a transparent lens increased 0.02 mm per year in both groups.…”

Section: Introductionmentioning

confidence: 99%

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An Index for Human Lens Transparency Related to Age and Lens Layer: Comparison between Normal Volunteers and Diabetic Patients with Still Clear Lenses

et al. 1999

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Objective: The light scattering intensity of normal, clear lenses varies with age and with the localization within the lens. Realizing the biometry of single lens areas together with their relevant light scattering intensity one should be able to calculate an index to express the lens transparency properties of normal human lenses in dependence on age. Performing the same procedure in cases of diabetic patients with still clear lenses it should become possible to obtain an index for the lens transparency properties of lenses under the ‘risk factor’ diabetes. Methods: 748 eyes with transparent lenses in 383 healthy individuals and 134 eyes with clear lenses in 70 subjects with diabetes were examined. Scheimpflug slit images of the lens were documented by a Nidek EAS-1000 instrument. Biometry for measuring the distance of the single lens layers from the anterior capsule and densitometry for determining the light scattering intensity of six defined lens layers along the (theoretical) optical axis were performed. The index of the lens transparency properties was calculated using the light scattering intensity of a defined lens layer and its distance from the anterior capsule. Results: Lens thickness and light scattering intensities increased linearly with increasing age in the normal population as well as in the diabetic patients. The densitogram pattern of the light scattering intensities in the defined representative six points was similar in both populations, but in the diabetic group the lens thickness was larger and the light scattering intensities were higher at all ages. Conclusion: The index of lens transparency properties calculated with the light scattering intensities of a certain lens area and its distance from the anterior capsule is a useful measure of lens clarity in dependence on age. ‘Clear’ lenses of the diabetic population show significantly higher indices for the lens transparency properties in all age groups.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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An Index for Human Lens Transparency Related to Age and Lens Layer: Comparison between Normal Volunteers and Diabetic Patients with Still Clear Lenses

et al. 1999

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“…As a method of detecting initial changes in cataract at an early stage, Hockwin et al [7] and Sasaki et al [8] proposed the use of light scattering intensity of Scheimpflug images of lens optical sections as an index, and recently this technique has begun to be applied not only for basic but also for clinical research [9][10][11]. In this model, light scattering intensity was measured to detect changes before the appearance of apparent opacification.…”

Section: Discussionmentioning

confidence: 99%

An Alternative Method of Steroid-Induced Lens Opacification in Brown Norway Rat Eyes Applying Systemic Pulse Administration

Nagai

Sekiya²,

Kojima³

et al. 2004

Ophthalmic Res

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Purpose: To confirm whether long-term administration of prednisolone sodium succinate (prednisolone) alone is able to induce cataract in rat eyes. Materials and Methods: A 1% solution of prednisolone was administered topically as eye drops to Brown Norway rat eyes, and a systemic pulse administration of 10 mg/kg/day was given via the tail vein. Both administration methods were applied in different combinations. Eighty-three 6-week-old male rats were divided into 8 groups: group 1 = control; group 2 = topical instillation every day; group 3 = single pulse; group 4 = single pulse + eye drops; group 5 = 3 times pulse; group 6 = 3 times pulse + eye drops; group 7 = 3 times pulse per 2 months; group 8 = 3 times pulse per 2 months + eye drops. Observations for changes of lens transparency were made by slitlamp microscopy and documented by an anterior eye segment analysis system (Nidek EAS-1000^®) from the onset of drug administration to a maximum period of 16 months. Results: Lens opacity in the shallow anterior and posterior lens layers developed from the tenth month following commencement of prednisolone administration. The incidence of anterior and/or posterior cortical cataract at the sixteenth month was 15% in group 2, 12.5% in group 5, 25% in group 6, 17.9% in group 7 and 35.3% in group 8. The lenses of groups 1, 3 and 4 maintained their transparency throughout the observation period. Light scattering intensity in groups 8 and 7 was the highest, followed by groups 6 and 5, then groups 2, 4, 3 and 1. Conclusion: Cortical cataract was successfully induced in Brown Norway rat eyes by sustained administration of prednisolone succinate alone applied as systemic pulse.

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Normal Aging Changes of the Scattering Light Intensity in Human Lens Measuring with Scheimpflug Photography

Cited by 2 publications

References 0 publications

An Index for Human Lens Transparency Related to Age and Lens Layer: Comparison between Normal Volunteers and Diabetic Patients with Still Clear Lenses

An Index for Human Lens Transparency Related to Age and Lens Layer: Comparison between Normal Volunteers and Diabetic Patients with Still Clear Lenses

An Alternative Method of Steroid-Induced Lens Opacification in Brown Norway Rat Eyes Applying Systemic Pulse Administration

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