Normal Anatomy, Histology, Immunohistology, Ultrastructure, Rat

Dijkstra, Christine D.; Sminia, T.

doi:10.1007/978-3-642-84110-1_40

Cited by 8 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The rodent thymus develops from the endoderm of the 3rd and 4th pharangeal pouches and surrounding mesenchyme. (Dijkstra and Sminia, 1990) The pharangeal pouch connects with the pharynx via the thymopharangeal duct, remnants of which may be incorporated into the developing thymus giving rise to epithelial cystic structures (Figures 1 and 2). As development progresses, the thymus along with the thyroid and parathyroid, sharing the same pharangeal pouch origin, migrate caudally.…”

Section: Embrology/developmentmentioning

confidence: 99%

Normal Structure, Function and Histology of the Thymus

2006

View full text Add to dashboard Cite

The thymus, a primary lymphoid organ and the initial site for development of T cell immunological function, is morphologically similar across species. It is actually an epithelial organ in which its epithelial cells provide a framework containing T cells as well as smaller numbers of other lymphoid cells. A symbiotic interaction exists between the thymic microenvironment and developing T cells, and the specificity of T cell release into the systemic circulation is under thymic control. The thymic cortex in a young animal is heavily populated by developing T cells along with a smaller proportion of associated epithelial cells. Larger, more mature T cells are found in the medulla where epithelial and other cell types are more abundant. Understanding normal morphological features of the thymus and their perturbations provides a cornerstone to assessing immune system function.

show abstract

Section: Embrology/developmentmentioning

confidence: 99%

Normal Structure, Function and Histology of the Thymus

2006

View full text Add to dashboard Cite

show abstract

“…(Klenerman et al, 2017). The thymic frame consists of cross-linked epithelial cells between which evolve maturing T lymphocytes and macrophages (Moticka et al, 2016), in the superficial cortex, reticular epithelial cells or feeder cells are distinguished from lymphocytes only by their paler, ovoid nucleus, in the deep cortex, the reticular epithelial cells are involved in lymphocyte selection, the Hassal corpuscles, characteristic of the thymic medulla, consist of epithelial cells arranged concentrically in a bulb and undergoing a keratinization process from the periphery to the center, the outermost cells are less mature than the central cells loaded with keratin (Dijkstra et al, 1990). The immune system is thus able to respond to external stimuli intervening anywhere in the body.…”

Section: Introductionmentioning

confidence: 99%

Study of anatomical, histological and cytological characteristics of the thymus of lambs

Rahmoun¹,

Lieshchova²,

Chaanbi³

et al. 2020

TAVM

View full text Add to dashboard Cite

Thymus of lambs of the Ouled-Djellal breed from eastern Algeria, aged one to 10 months, were used to study the anatomical, histological and cytological characteristics of these organs. Modern techniques have been used to demonstrate the morphometric parameters and masses of the thymus at different ages, a regression of the morphometric and mass indexes has been visualized according to the age of the lambs. Staining techniques with Hematoxylin and eosin revealed the normal structure of the thymus with its tissue components. The thymus is bilobed. The lobe is surrounded by a thin capsule and subdivided into lobules separated by septae, the cortical and medullary areas were clearly visible, the interlobular blood vessels enter the lobule in all its aspects to continue its way as interlobular blood vessels. From the changes observed in the involution of the thymus according to the age of the animals which occur relatively late, the percentage of the surface found for the capsule was very variable, which increases from the first to the tenth month, the demarcation of the cortex and the medulla beginning during the second month of age of the animal. The interlobular connective tissue (ILC) presents sums, the maximum of which was found in the fourth month of age of the animal, while the minimum was found in the thymus of ninth month lambs Concerning the Hassal corpuscles, their sums are in high extension until the tenth month, rich in T lymphocytes, whose use of immunohistochemistry, the anti-CD 157+ antibody allowed us to visualize to locate them clearly, which invade and form most of the thymus cortex. In conclusion, the significant changes in thymus development in sheep of the Ouled-Djellal breed are similar to those of other species.

show abstract

“…A população linfóide tímica imunofenotipicamente é heterogênea, caracterizando diferentes estágios de maturação na região cortical (DIJKSTRA; SMINIA, 1990;PICKER;SIEGELMAN, 1993;XAVIER, 1999). O acesso das células progenitoras ao timo de camundongos ocorre através de grandes vênulas medulares e da junção córtico-medular.…”

Section: Introductionunclassified

Desenvolvimento embrionário tímico em fetos de gatos domésticos (Felis domesticus)

Barroso¹

2012

Biotemas

View full text Add to dashboard Cite

Submetido em 23/07/2011 Aceito para publicação em 16/04/2012 ResumoDurante a vida fetal e no período neonatal o timo é um órgão de grande importância imunológica e, anatomicamente é o maior órgão linfático, com alta atividade linfopoiética, constando como precursor da linfopoiese. Estudos morfológicos sobre o desenvolvimento do timo são pouco esclarecedores e quando ocorrem englobam o assunto de forma genérica. Diante do exposto este estudo teve como objetivo caracterizar o desenvolvimento morfológico do timo de embriões e fetos de gatos domésticos (Felis domesticus), provenientes de gestação natural, utilizando as técnicas macroscópicas de dissecação e microscópica de luz. O timo dos gatos apresentou coloração rosa pálido e estava repousando na região do mediastino cranial, medialmente aos pulmões e dorsalmente à base do coração. Histologicamente apresentou duas regiões distintas, denominadas de cortical e de medular. Na região medular, foram evidenciadas células reticulares epiteliais com um núcleo grande e prolongamentos dendríticos. Os fetos apresentaram um desenvolvimento exponencial e mais acentuado a partir do 35º dia de gestação. Palavras-chave: Anatomia veterinária; Embriologia veterinária; Gatos; Timo Abstract Embryonic thymic development in fetuses of domestic cats (Felis domesticus).During fetal life, and during the neonatal period, the thymus is a very important immune organ, and is the largest lymphatic organ, which exhibits high lymphopoietic activity as a precursor of lymphopoiesis. Morphological studies on the development of the thymus are rare and only include general information. Given the above, this study aimed to characterize the morphological development of the thymus of embryos and fetuses of domestic cats (Felis domesticus), from natural pregnancy, using macroscopic dissection techniques and light microscopy. The thymus of the cats was pale pink and was resting in the region of the cranial mediastinum, medially to the lungs and dorsally to the base of the heart. Histologically, two distinct regions were observed (cortical and medullar). The medullary region had reticular epithelial cells with large nuclei and dendritic extensions. The fetuses had exponential growth and were more pronounced starting on the 35 th day of gestation.

show abstract

Normal Anatomy, Histology, Immunohistology, Ultrastructure, Rat

Cited by 8 publications

References 21 publications

Normal Structure, Function and Histology of the Thymus

Normal Structure, Function and Histology of the Thymus

Study of anatomical, histological and cytological characteristics of the thymus of lambs

Desenvolvimento embrionário tímico em fetos de gatos domésticos (Felis domesticus)

Contact Info

Product

Resources

About