Normal and abnormal physiology of the alimentary tract in infancy

Tyson, Kenneth R.T.

doi:10.1016/0002-9610(69)90077-4

Cited by 3 publications

(1 citation statement)

References 64 publications

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“…7,32 Infants who are closer to term, whose mothers received antenatal betamethasone, or who are enterally fed have rapid maturation of duodenal motility. 2,6,8 Erythromycin competitively binds motilin receptors and can induce migrating motor complexes in infants older than 32 weeks' gestation. 33 Positioning after feeding is not an important factor in gastric emptying in neonates.…”

Section: Proteolytic Activitymentioning

confidence: 99%

Upper Gastrointestinal Tract Bleeding in Critically Ill Pediatric Patients

Crill

Hak

1999

Pharmacotherapy

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Similar to adults, children under physiologic stress can develop an imbalance in defensive (mucosal layer, motility) and aggressive (gastric acid, bile salts, enzymes) factors responsible for maintaining a healthy gastrointestinal tract. Hypoxia in the gastrointestinal tract likely disrupts the defensive factors, thereby permitting damage by aggressive factors to upper gastrointestinal epithelium that may progress to stress ulceration and acute upper gastrointestinal tract bleeding (UGIB). The basic pathophysiology may be similar in children and adults; however, differences in the time to developing ulceration, ulcer location, and number of ulcers have been reported. Functional development of the gastrointestinal tract is influenced by disease, gestational and postnatal age, and exposure to and type of enteral feedings, thereby confounding the development and prophylaxis of UGIB in neonates and infants. In addition, pharmacotherapy decisions are often complicated by drug administration issues and adverse effects.

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