In this paper, we study the weighted composition operator on the Fock space F 2 (H) of slice regular functions. First, we characterize the boundedness and compactness of the weighted composition operator. Subsequently, we describe all the isometric composition operators. Finally, we introduce a kind of (right)-anticomplex-linear weighted composition operator on F 2 (H) and obtain some concrete forms such that this (right)-anti-linear weighted composition operator is a (right)-conjugation. Specially, we present equivalent conditions ensuring weighted composition operators which are conjugate C a,b,c −commuting or complex C a,b,c − symmetric on F 2 (H), which generalized the classical results on F 2 (C). At last part of the paper, we exhibit the closed expression for the kernel function of F 2 (H).2010 Mathematics Subject Classification. Primary: 30G35, 47B38, 47B15, 30H20.