Normal blood pressure and preserved diurnal variation in offspring of type 2 diabetic patients characterized by features of the metabolic syndrome: the Fredericia Study.

Foss, Catherine H; Vestbo, E.; Frøland, Anders; Gjessing, H. J.; Mogensen, C. E.; Damsgaard, Else Marie

doi:10.2337/diacare.23.3.283

Cited by 21 publications

(14 citation statements)

References 7 publications

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“…Several other studies investigated the relationship between diurnal blood pressure and MS but they failed to find such relation (Foss et al 2000;Cuspidi et al 2004a). In contrast, the findings of this study were consistent to show a close relation with MS-Score but not with MS-ATP III which was used in the determination of all previous MS studies.…”

Section: Discussioncontrasting

confidence: 56%

Metabolic Syndrome as a Predictor of Non-Dipping Hypertension

Tartan

Uyarel

Kaşıkçıoğlu

et al. 2006

Tohoku J. Exp. Med.

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Metabolic syndrome (MS) and nondipping hypertension both increase cardiovascular mortality. Although both clinical modalities share common pathophysiologic factors in their etiologies, previous studies did not find any association between them. We aimed to investigate the association between MS and non-dipping blood pressure by comparing different definitions of MS. One hundred-thirty-two consecutive patients (58 men) who underwent 24-hour ambulatory blood pressure monitoring were analyzed. MS was evaluated according to the currently used Adult Treatment Panel (ATP) III definition criteria, named MS-ATP III. In order to reveal the weights of risk contributing to MS, a new diagnostic scoring method (MS-Score) was used in comparison with MS-ATP III. Nocturnal non-dipping refers to a reduction in average systolic and/or diastolic blood pressure at night ( 10%) compared with daytime average values. Non-dipping pattern was found in 61.4% of patients. The frequency of MS according to MS-Score, but not MS ATP III, was significantly higher in patients with nondipping pattern than those without it ( p = 0.009). Although more prominent in the nighttime, MS-Score showed positive correlation with all systolic blood pressure results (r = 0.27, p = 0.002). Adjusted for baseline characteristics, high ( 27.5) MS-Score remained as an independent predictor of non-dipping pattern (OR 2.64, p = 0.038). Finally, high MS-Score, but not MS-ATP III, is a predictor of non-dipping pattern. Nighttime systolic blood pressure is higher in patients with high MS-Score. Therefore, patients with high MS-Score may be more prone to cardiovascular events than those with low MSScore.circadian blood pressure variation; hypertension; metabolic syndrome score; metabolic syndrome adult treatment panel III; non-dipping pattern

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Section: Discussioncontrasting

confidence: 56%

Metabolic Syndrome as a Predictor of Non-Dipping Hypertension

Tartan

Uyarel

Kaşıkçıoğlu

et al. 2006

Tohoku J. Exp. Med.

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“…Control subjects were recruited from the Fredericia Study (8). For each patient in the DMa group, we identified and included a control subject with normal glucose tolerance (NGT) as well as a subject with impaired glucose tolerance (IGT) who matched best with regard to gender and age.…”

Section: Subjectsmentioning

confidence: 99%

E-selectin-inducing activity in plasma from type 2 diabetic patients with maculopathy

Knudsen

Foss

Poulsen

et al. 2003

American Journal of Physiology-Endocrinology and Metabolism

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“…Several other studies investigating the potential relationship between MS and circadian BP pattern have not always detected a relation between MS and non-dipping (Bastos et al, 2007;Cuspidi et al, 2004bCuspidi et al, , 2005Foss et al, 2000;Mancia et al, 2007a), leading to contradictory results. For instance, Cuspidi et al (2004bCuspidi et al ( , 2005 found no significant difference in nocturnal BP, assessed by two consecutive 24 h ABPM sessions, in untreated essential hypertensive MS patients compared to those without it.…”

Section: Discussionmentioning

confidence: 93%

“…However, the association between MS and non-dipper BP patterning seems controversial (Bastos et al, 2007;Cuspidi et al, 2004bCuspidi et al, , 2005Foss et al, 2000;Hermida et al, 2009b;Mancia et al, 2007a;Tartan et al, 2006;Vyssoulis et al, 2007). Among other factors, this might be due to differences in the studied populations (i.e., normotensive subjects, untreated hypertensives, treated hypertensives), relatively small sample sizes, potential differing effects of individual components of MS on an altered BP pattern, and frequent use of low-reproducible single 24 h ambulatory BP monitoring (ABPM).…”

Section: Introductionmentioning

confidence: 97%

Circadian Pattern of Ambulatory Blood Pressure in Untreated Hypertensive Patients with and without Metabolic Syndrome

Ayala

Hermida

Chayán

et al. 2009

LCBI

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There is a strong association between metabolic syndrome (MS) and increased risk of end-organ damage, cardiovascular disease, stroke, and cardiovascular mortality. Moreover, non-dipping (<10% decline in the asleep relative to the awake blood pressure [BP] mean) and elevated ambulatory pulse pressure (PP), among other factors related to the circadian BP pattern, have also been associated with increased cardiovascular morbidity and mortality. This cross-sectional study investigated the circadian BP pattern in 2,045 non-diabetic untreated patients with uncomplicated essential hypertension (941 men/1,099 women), 48.7+/-11.9 yrs of age, classified by the presence or absence of MS. BP was measured by ambulatory monitoring for 48 consecutive hours to substantiate reproducibility of the dipping pattern. Physical activity was simultaneously monitored every min by wrist actigraphy to accurately calculate mean BP when awake and asleep for each subject. MS was present in 40.7% of the patients. Patients with MS were characterized by a significantly higher 24 h mean of systolic BP and a lower diastolic BP compared to patients without MS. Accordingly, ambulatory PP was significantly elevated the entire 24 h in MS patients. The prevalence of an altered non-dipper BP profile was significantly higher in MS patients (48.4 vs. 36.1% in patients without MS, p < 0.001). MS patients were characterized, among other risk factors, by significantly higher uric acid, fibrinogen, leukocyte count, hemoglobin and globular sedimentation velocity, plus lower estimated glomerular filtration rate. Apart from corroborating the significant increased prevalence of a blunted nocturnal BP decline in MS, this study documents ambulatory PP is higher in MS, without differences between groups in mean arterial pressure. This elevated PP might reflect increased arterial stiffness in MS. MS patients were also characterized by elevated values of relevant markers of cardiovascular risk, including fibrinogen and globular sedimentation velocity. These collective findings indicate that MS should be included among the clinical situations in which ambulatory BP monitoring is recommended.

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Normal blood pressure and preserved diurnal variation in offspring of type 2 diabetic patients characterized by features of the metabolic syndrome: the Fredericia Study.

Cited by 21 publications

References 7 publications

Metabolic Syndrome as a Predictor of Non-Dipping Hypertension

Metabolic Syndrome as a Predictor of Non-Dipping Hypertension

E-selectin-inducing activity in plasma from type 2 diabetic patients with maculopathy

Circadian Pattern of Ambulatory Blood Pressure in Untreated Hypertensive Patients with and without Metabolic Syndrome

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