Background Increased attention is being placed on hip preservation surgery in the early adolescent. An understanding of three-dimensional (3-D) acetabular development as children approach maturity is essential. Changes in acetabular orientation and cartilage topography have not previously been quantified as the adolescent acetabulum completes development. Questions/purposes We used a novel 3-D CT analysis of acetabular development in children and adolescents to determine (1) if there were sex-specific differences in the growth rate or surface area of the acetabular articular cartilage; (2) if there were sex-specific differences in acetabular version or tilt; and (3) whether the amount of version and tilt present correlated with acetabular coverage. Methods We assessed acetabular morphology in 157 patients (314 hips); 71 patients were male and 86 were female. Patient ages ranged from 8 years to 17 years. A 3-D surface reconstruction of each pelvis was created from CT data using MIMICs software. Custom MATLAB software was used to obtain data from the 3-D reconstructions. We calculated articular surface area, acetabular version, and acetabular tilt as well as novel measurements of acetabular morphology, which we termed ''coverage angles.'' These were measured in a radial fashion in all regions of the acetabulum. Data were organized into three age groups: 8 to 10 years old, 10 to 13 years old, and 13 to 17 years old. Results Male patients had less acetabular anteversion in all three age groups, including at maturity (7°versus 13°, p \ 0.001; 10°versus 17°, p \ 0.001; 14°versus 20°, p \ 0.001). Males had less acetabular tilt in all three age groups (32°versus 34°, p = 0.03; 34°versus 38°, p \ 0.001; 39°versus 41°, p = 0.023). Increases in anteversion correlated with increased posterior coverage angles (r = 0.805; p \ 0.001). Increases in tilt were correlated with increases in superior coverage angles (r = 0.797; p \ 0.001). The posterosuperior regions of the acetabulum were the last to develop and this process occurred earlier in females compared with males.