Normal Growth and Persistence of Corpora Lutea of Both Ovaries in the Unilaterally Pregnant Guinea-Pig

Independent Regression of Normal and Induced Corpora Lutea in Hysterectomized Guinea-Pigs

“…Determinations of corpus luteum size were made by measuring two diameters at right angles across the largest sections through each corpus luteum, and calculating the third diameter from the number of sections in which the corpus luteum appeared (Deanesly, 1967). The average of these three diameters was then taken as the individual mean diameter.…”

Effects of Hysterectomy on Corpus Luteum Activity in the Cyclic, Pseudopregnant and Pregnant Mouse

“…The experiment indicates also that the placental influence on ovarian activity is entirely or predominantly systemic. This systemic luteotrophic action of the placentae might override any luteo¬ lytic effect of the mouse uterus, as has been suggested for the rat (Strauss & Lindner, 1969) and the guinea-pig (Deanesly, 1967). However, the experiments described above which demonstrate that the uterus has no effect on the life of the CL after placental removal make such an explanation unnecessary in mice.…”

Control of Luteal Function During Early Pregnancy in the Guinea-Pig

“…(Zarrow, 1948), the vaginal opening in pregnancy reported by Ford et al (1951) was more probably due to high circulating relaxin levels. The high circulating levels of progesterone in pregnancy (Heap & Deanesly, 1966, 1967 …”

“…By contrast, the fact that unilateral pregnancy allows the maintenance and enlargement of the corpora lutea in both ovaries, at least to the 25th day p.c. (Bland & Donovan, 1967;Deanesly 1967;Oxenreider & Day, 1967) might suggest the existence of a systemically-borne, anti-luteolytic or luteotrophic factor. In the first part of the present study, the need for continued presence of the placental complex for luteal maintenance was examined.…”