Normal human salivary glands

Riva, Alessandro; Lantini, Maria Serenella; Riva, F.

doi:10.1007/978-1-4613-0869-0_4

Cited by 24 publications

(17 citation statements)

References 58 publications

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“…It is noteworthy that the thicker MEC processes occur on the glands with the more viscous secretions. Other investigators have demonstrated a similar hierarchy by SEM in rat (Brocco and Tamarin, 1979;Mark et al, 1981) and human (Riva et al, 1989(Riva et al, , 1990) salivary glands.…”

Section: Scanning Electron Microscopymentioning

confidence: 58%

“…As previously mentioned, MEC share many features with smooth muscle cells 19). These include parallel arrays of filaments which are gathered in "dense bodies" and are anchored to the basal plasmalemma in attachment plaques; fusiform nuclei parallel to the long axis of the cell (muscle) or its longest processes (ductal MEC, at least); numerous caveolae, mostly in the basal plasmalemma; occasional collections of glycogen particles; sparse rough endoplasmic reticulum and Golgi zones; and a basal lamina (Bois, 1973;Cutler and Chaudhry, 1973a;Cutler et al, 1977;Garrett and Emmelin, 1979;Nagashima and Ono, 1985;Pinkstaff, 1980;Redman and Ball, 1979;Redman et al, 1980;Riva et al, 1988Riva et al, , 1990Scott and Pease, 1959;Taga and Sesso, 1979;Tamarin, 1966;Tandler, 1965Tandler, , 1987Tandler et al, 1970;Testa Riva, 1977;Young and van Lennep, 1977). Nuclei of MEC on acini tend to have the shape of a convex disk (Garrett and Emmelin, 1979), but are most easily recognized as belonging to MEC in cross sections, where their juxtaposition to acinar cells is apparent.…”

Section: Mecmentioning

confidence: 99%

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Myoepithelium of salivary glands

Redman¹

1994

Microscopy Res & Technique

154

146

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In salivary glands and other exocrine organs, there are starfish-shaped cells that lie between the basal lamina and the acinar and ductal cells. These have structural features of both epithelium and smooth muscle cells, and so are called myoepithelial cells. Their functions include contraction when the gland is stimulated to secrete, compressing or reinforcing the underlying parenchymal cells, thus aiding in the expulsion of saliva and preventing damage to the other cells. They also may aid in the propagation of secretory and other stimuli. Their common developmental origin with the basal cells of the larger ducts is displayed in the mature glands by shared structural and immunohistochemical features, but most such basal cells do not have the distinguishing features of myoepithelial cells, such as myofibrils. Although myoepithelial cells can be identified by light microscopy through enzyme histochemistry and special stains and immunohistochemistry for their myofibrils, these techniques can be misleading in salivary gland neoplasms. Thus, the most reliable means of identifying neoplastic myoepithelial cells is with a combination of histochemistry and electron microscopy. The extent to which these cells are derived from undifferentiated stem cells in both normal and neoplastic growth is controversial. The presentation here of transmission electron microscopy (TEM) of well-differentiated myoepithelial cells in mitotic division indicates that stem cells are not necessarily the only source of myoepithelial cells in the later stages of salivary gland development or in neoplasia.

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Section: Scanning Electron Microscopymentioning

confidence: 58%

Section: Mecmentioning

confidence: 99%

Myoepithelium of salivary glands

Redman¹

1994

Microscopy Res & Technique

154

146

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“…This finding indicates that, among the major salivary glands, parotid is the most involved in melatonin release. It is noteworthy that the degree of participation to melatonin supply represents a further feature distinguishing the salivary glands from one another, in addition to many anatomical, embryonic, histochemical and metabolic diversities .…”

Section: Discussionmentioning

confidence: 99%

Melatonin localization in human salivary glands

Isola

Lilliu

2015

J Oral Pathology Medicine

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“…For example, sialolithiasis affects more frequently the submandibular than the parotid gland (Huoh and Eisele, ), while neoplasies involve more frequently parotid glands (Nagler and Laufer, ); radiation damage chiefly involves parotid glands (Jeong et al, ), while xerostomia is more associated with submandibular dysfunction (Güne et al, ). Moreover, anatomical features, such as innervation and vascularization, histological, and histochemical properties, embryonic origin, genetic, and metabolic aspects distinguish parotid from submandibular glands (Riva et al, ; Tandler and Phillips, ; Denny et al, ) so that a different susceptibility to diabetic changes should not surprise.…”

Section: Discussionmentioning

confidence: 99%

Morphometric Study of Diabetes Related Alterations in Human Parotid Gland and Comparison with Submandibular Gland

Lilliu

Loy

Cossu

et al. 2015

The Anatomical Record

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Type 2 diabetes mellitus represents one of the principal diseases that afflict the world population and is often associated with malfunction of salivary glands and consequent oral diseases. We recently described significant ultrastructural alterations in the human submandibular gland in diabetic patients without evident oral pathologies. Herein, an analogs morphometrical investigation was focused on the parotid gland in order to evaluate if one of the two glands is more affected by diabetes. Parotid fragments from diabetic and nondiabetic patients were fixed, dehydrated, and processed for light and electron microscopy. Serous cells were randomly photographed and the density and size of several structures involved in the secretory process were examined by morphometry. Scanning electron microscopy images revealed significant changes in the number of apically docked granules and vesicles, suggesting that the last steps in exocytosis are somehow altered in diabetic cells. Other variables analyzed by light and transmission electron microscopy such as the size of acini and secretory granules did not show significant changes, but comparison with previous data obtained with submandibular gland cells demonstrated that the two glands are affected differently.

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Normal human salivary glands

Cited by 24 publications

References 58 publications

Myoepithelium of salivary glands

Myoepithelium of salivary glands

Melatonin localization in human salivary glands

Morphometric Study of Diabetes Related Alterations in Human Parotid Gland and Comparison with Submandibular Gland

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