1980
DOI: 10.1016/s0003-2670(01)95205-5
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Normal levels of trace elements in human blood plasma or serum

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Cited by 409 publications
(147 citation statements)
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“…Some trace elements form part of enzymes [e.g., Se in glutathionperoxidase (1) and copper in tyrosinase, ascorbic acid oxidase, cytochrome oxidase, uricase, and superoxid dismutase]. Others are involved in the synthesis of hormones [e.g., Se in the formation of trijodothyronin (1,2)]. Some trace elements are known to be associated with certain diseases if they are present in the body in abnormally low concentrations: Hemolytic anemias can develop in Zn deficiency and some form of coronary heart diseases are associated with Cu and Zn deficiency (3).…”
Section: Introductionmentioning
confidence: 99%
“…Some trace elements form part of enzymes [e.g., Se in glutathionperoxidase (1) and copper in tyrosinase, ascorbic acid oxidase, cytochrome oxidase, uricase, and superoxid dismutase]. Others are involved in the synthesis of hormones [e.g., Se in the formation of trijodothyronin (1,2)]. Some trace elements are known to be associated with certain diseases if they are present in the body in abnormally low concentrations: Hemolytic anemias can develop in Zn deficiency and some form of coronary heart diseases are associated with Cu and Zn deficiency (3).…”
Section: Introductionmentioning
confidence: 99%
“…Likewise in macro elements, the micro elements such as Cu, Mn, Zn and Se are involved in several metabolic or immunological processes in organisms by activating or inhibiting enzymatic reactions, by competing for binding sites with other elements and metalloproteins, by affecting the permeability of cell membranes or by several other mechanisms (29,30) in order to maintain the homeostasis (31,32). So, they have to be taken from several resources as fish in daily diet.…”
Section: Resultsmentioning
confidence: 99%
“…Maximal reduction of NFκB activity was seen when copper levels exceeded 10 μM, a concentration that exceeds physiological copper concentrations. 17 The impact of elevated copper levels on canonical NFκB-dependent gene induction patterns was then examined. mRNA was isolated from HEK293 cells, pretreated with clioquinol and increasing concentrations of CuSO 4 that were subsequently stimulated with TNF.…”
Section: Resultsmentioning
confidence: 99%