Normal matrix mineralization induced by strontium ranelate in MC3T3-E1 osteogenic cells

Barbara, A.; Delannoy, Ph.; Denis, Bérangère; Marie, Pierre J.

doi:10.1016/j.metabol.2003.10.022

Cited by 169 publications

(150 citation statements)

References 40 publications

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“…On the other hand SR has shown an increase in the alkaline phosphatase activity which is a marker for an increase in collagen synthesis and osteoblast differentiation. This supports the result which shows an improvement of the primary stability to the secondary stability (Canalis et al, 1996;Barbara et al, 2004;Kim et al, 2015).…”

Section: Discussionsupporting

confidence: 90%

Effects of Strontium Ranelate on Alveolar Ridge Morphology Augmentation

Xuan

Kwon³

et al. 2017

Int. J. Morphol.

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XUAN, J.; WU, X. P.; KWON, T. G. ; KYUNG, H. M. & BING, L.Effects of strontium ranelate on alveolar ridge morphology augmentation. Int. J. Morphol., 35(4):1328Morphol., 35(4): -1331Morphol., 35(4): , 2017. SUMMARY:The objective of this study was to compare the Primary and Secondary stability of immediate implant placement with Alveolar Ridge Augmentation (ARA) and Strontium Ranelate (SR) as aids to enhance the stability using Resonance Frequency Analysis (RFA). Fifty eight subjects ideal for immediate implants were assigned to two groups to compare the primary and secondary stability of the implant using Alveolar Ridge Augmentation and oral strontium ranelate. They were tested for primary stability on placement of the implant and after eight weeks of placement for secondary stability. The stability was measured using resonance frequency analysis. Both the procedures showed an improvement in the stability but the Alveolar Ridge Augmentation procedure showed a significantly better primary stability (P< .03) and the secondary stability (P<.00). The means of the implant stability quotient value (ISQ) for the Alveolar ridge augmentation procedure was 74.2 for primary stability, and 83.34 for secondary stability. With the enhancement of stability with both the procedures Alveolar Ridge Augmentation proved to be a better procedure to achieve successful results of an immediately placed implant.

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Section: Discussionsupporting

confidence: 90%

Effects of Strontium Ranelate on Alveolar Ridge Morphology Augmentation

Xuan

Kwon³

et al. 2017

Int. J. Morphol.

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“…Barbara et al reported that 0.1-1 mM (8-80 ppm) of strontium ranelate inhibit bone resorption and enhance bone formation. 28) In the glasses prepared in the present work, > 0.1 mM of Sr 2+ ions were released from the glasses containing more than 20 mol% of SrO, while < 1 mM of the ions were released from the glass containing of 60 mol% of SrO. Calcium is one of the important elements for bone formation.…”

Section: +mentioning

confidence: 60%

Ion release from SrO-CaO-TiO2-P2O5 glasses in Tris buffer solution

Lee

Obata

Kasuga

2009

J. Ceram. Soc. Japan

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SrO-containing calcium phosphate invert glasses, (60-x)CaO•xSrO•30P2O5•7Na2O•3TiO2 (mol%, x = 0 -60), which are expected to inhibit bone resorption by osteoclast and enhance bone formation, were prepared and their ion release behaviors in Tris buffer solution were estimated. The glass containing 20 mol% of SrO showed the smallest amount of the dissolved ions in the present work. Laser Raman spectra showed that the peaks of phosphate groups and TiOy polyhedral groups red-shifted with increasing the SrO content in the glasses. The shift was suggested to be due to decrease in bonding strength between cations and phosphate groups or TiOy polyhedral groups in the glasses. In the case of the glasses containing SrO over 20 mol%, no shifts of Raman peaks due to the TiOy polyhedra were observed. The TiOy (y = 4 or 6) polyhedra in the glasses can coordinate with cations up to 18 mol% since they contain 3 mol% of TiO2. Sr 2+ ions are supposed from the shift behavior of the Raman peaks to preferentially coordinate with the TiOy polyhedra; the formation of this structure would induce decrease in the ion amounts released from the glasses containing 0 -20 mol% of SrO.

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“…Strontium ranelate was reported to act by inhibiting bone resorption and promoting bone formation [5], thereby inducing a positive bone balance in experimental osteopenic models [6,7] and in patients with postmenopausal osteoporosis [3][4][5]8]. Previous studies indicate that strontium ranelate may act on osteoblasts to promote cell activity and differentiation [9][10][11][12]. Notably, others and we showed that strontium ranelate can activate cell replication in rodent calvaria osteoblasts, resulting in stimulation of collagen synthesis [9,13] …”

Section: Bone Loss Associated With Aging Oestrogen Deficiency Immobmentioning

confidence: 70%

Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate

Fromigué

Haÿ

Barbara

et al. 2009

Journal of Cellular and Molecular Medicine

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Introduction Bone loss associated with aging, oestrogen deficiency, immobilization or glucocorticoid treatment is characterized by insufficient bone formation relative to resorption, resulting in negative bone balance, alterations of bone mass and increased incidence of fractures [1,2] [3,4]. Strontium ranelate was reported to act by inhibiting bone resorption and promoting bone formation [5], thereby inducing a positive bone balance in experimental osteopenic models [6,7] and in patients with postmenopausal osteoporosis [3][4][5]8]. Previous studies indicate that strontium ranelate may act on osteoblasts to promote cell activity and differentiation [9][10][11][12]. Notably, others and we showed that strontium ranelate can activate cell replication in rodent calvaria osteoblasts, resulting in stimulation of collagen synthesis [9,13]

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Normal matrix mineralization induced by strontium ranelate in MC3T3-E1 osteogenic cells

Cited by 169 publications

References 40 publications

Effects of Strontium Ranelate on Alveolar Ridge Morphology Augmentation

Effects of Strontium Ranelate on Alveolar Ridge Morphology Augmentation

Ion release from SrO-CaO-TiO2-P2O5 glasses in Tris buffer solution

Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate

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